SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 1o8u 6-OXO CAMPHOR
HYDROLASE
(Rhodococcus
erythropolis) 		4 / 5 LEU A 241
LEU A 237
LEU A 229
GLY A 155
 None
 0.90A 1a4lC-1o8uA:
undetectable		 1a4lC-1o8uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1o8u 6-OXO CAMPHOR
HYDROLASE
(Rhodococcus
erythropolis) 		5 / 11 ASN A 103
LEU A  66
ALA A  49
GLY A  97
PHE A  73
 None
 1.37A 1l5rA-1o8uA:
undetectable		 1l5rA-1o8uA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1o8u 6-OXO CAMPHOR
HYDROLASE
(Rhodococcus
erythropolis) 		5 / 12 SER A 129
LEU A 104
ASP A 154
LEU A 173
HIS A 145
 None
 1.02A 1uobA-1o8uA:
undetectable		 1uobA-1o8uA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 1o8u 6-OXO CAMPHOR
HYDROLASE
(Rhodococcus
erythropolis) 		3 / 3 VAL A 158
TRP A 160
VAL A 163
 None
 0.86A 2izqA-1o8uA:
undetectable
2izqB-1o8uA:
undetectable		 2izqA-1o8uA:
7.48
2izqB-1o8uA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 1o8u 6-OXO CAMPHOR
HYDROLASE
(Rhodococcus
erythropolis) 		3 / 3 VAL A 163
VAL A 158
TRP A 160
 None
 0.91A 3l8lA-1o8uA:
undetectable
3l8lB-1o8uA:
undetectable		 3l8lA-1o8uA:
7.48
3l8lB-1o8uA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1o8u 6-OXO CAMPHOR
HYDROLASE
(Rhodococcus
erythropolis) 		4 / 5 LEU A 164
ALA A 184
PHE A 140
ASN A 191
 None
 0.97A 3uq6A-1o8uA:
undetectable		 3uq6A-1o8uA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1o8u 6-OXO CAMPHOR
HYDROLASE
(Rhodococcus
erythropolis) 		4 / 4 LEU A 164
ALA A 184
PHE A 140
ASN A 191
 None
 1.02A 3vaqA-1o8uA:
undetectable		 3vaqA-1o8uA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1o8u 6-OXO CAMPHOR
HYDROLASE
(Rhodococcus
erythropolis) 		4 / 4 LEU A 164
ALA A 184
PHE A 140
ASN A 191
 None
 0.98A 3vasA-1o8uA:
undetectable		 3vasA-1o8uA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1o8u 6-OXO CAMPHOR
HYDROLASE
(Rhodococcus
erythropolis) 		5 / 8 ALA A 203
GLY A 209
PRO A 110
VAL A 111
ILE A 112
 None
 1.50A 4ll3A-1o8uA:
undetectable		 4ll3A-1o8uA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 1o8u 6-OXO CAMPHOR
HYDROLASE
(Rhodococcus
erythropolis) 		5 / 11 LEU A  28
ALA A 207
ILE A 131
THR A  67
ILE A  65
 None
 0.93A 4njtC-1o8uA:
undetectable		 4njtC-1o8uA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 1o8u 6-OXO CAMPHOR
HYDROLASE
(Rhodococcus
erythropolis) 		4 / 4 ILE A  77
LEU A  38
HIS A  45
ALA A  44
 None
 1.02A 6ck2C-1o8uA:
undetectable
6ck2D-1o8uA:
undetectable		 6ck2C-1o8uA:
6.55
6ck2D-1o8uA:
12.88