SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o9g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 12 PHE A  40
ARG A  74
GLY A  70
LEU A 100
LEU A  97
 None
 1.16A 1gseA-1o9gA:
0.0		 1gseA-1o9gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		6 / 12 GLY A  70
LEU A  71
LEU A 138
GLY A 104
ALA A  98
ALA A  94
 None
 1.26A 2bm9F-1o9gA:
7.9		 2bm9F-1o9gA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 12 GLY A  61
LEU A  65
VAL A  85
ASP A 175
PRO A 177
 None
 0.84A 2f8lA-1o9gA:
13.3		 2f8lA-1o9gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 10 LEU A  71
LEU A 100
LYS A  95
ASN A  96
ARG A 108
 None
 1.16A 2riwA-1o9gA:
0.3
2riwB-1o9gA:
0.0		 2riwA-1o9gA:
22.35
2riwB-1o9gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 5 VAL A 221
VAL A 212
ASP A 214
SER A 236
 None
 0.92A 2x45A-1o9gA:
undetectable		 2x45A-1o9gA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 5 VAL A 221
VAL A 212
ASP A 214
SER A 236
 None
 0.95A 2x45C-1o9gA:
0.0		 2x45C-1o9gA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		3 / 3 ASP A  84
ASP A 153
ASP A 175
 None
 0.71A 3douA-1o9gA:
10.6		 3douA-1o9gA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 12 GLY A  61
GLY A  63
ASN A  96
ALA A  88
PHE A  31
 None
 1.04A 3p2kC-1o9gA:
9.0		 3p2kC-1o9gA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 6 VAL A 193
VAL A 154
ILE A 210
ARG A 181
 None
 1.05A 3pyyA-1o9gA:
undetectable		 3pyyA-1o9gA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 12 THR A 213
SER A 236
LEU A 197
VAL A 193
ALA A 226
 None
 1.45A 3u9fD-1o9gA:
2.0
3u9fE-1o9gA:
1.8		 3u9fD-1o9gA:
20.08
3u9fE-1o9gA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 10 LEU A 173
ARG A   5
GLU A 228
LEU A 230
VAL A 209
 None
 1.28A 3ua5B-1o9gA:
0.0		 3ua5B-1o9gA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		3 / 3 SER A 216
ASP A 175
ASP A  84
 None
 0.91A 3uj7A-1o9gA:
10.3		 3uj7A-1o9gA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 7 ILE A  39
LEU A  35
ALA A 237
VAL A 238
 None
 0.59A 4g77A-1o9gA:
undetectable		 4g77A-1o9gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 12 LEU A  66
GLU A 180
GLY A  61
ALA A  93
ILE A 149
 None
 1.14A 4hytA-1o9gA:
undetectable		 4hytA-1o9gA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 12 LEU A  66
GLU A 180
GLY A  61
ALA A  93
ILE A 149
 None
 1.14A 4hytC-1o9gA:
0.0		 4hytC-1o9gA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 8 ALA A 211
LEU A  65
ALA A  36
LEU A  69
ALA A  43
 None
 1.06A 4z90A-1o9gA:
0.0
4z90B-1o9gA:
0.0
4z90C-1o9gA:
0.0
4z90D-1o9gA:
0.0
4z90E-1o9gA:
0.0		 4z90A-1o9gA:
24.11
4z90B-1o9gA:
24.11
4z90C-1o9gA:
24.11
4z90D-1o9gA:
24.11
4z90E-1o9gA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 8 ALA A 211
LEU A  65
ALA A  36
LEU A  69
LEU A  55
 None
 1.13A 4z90A-1o9gA:
0.0
4z90B-1o9gA:
0.0
4z90C-1o9gA:
0.0
4z90D-1o9gA:
0.0
4z90E-1o9gA:
0.0		 4z90A-1o9gA:
24.11
4z90B-1o9gA:
24.11
4z90C-1o9gA:
24.11
4z90D-1o9gA:
24.11
4z90E-1o9gA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 8 LEU A  69
LEU A  55
ALA A 211
LEU A  65
ALA A  36
 None
 1.14A 4z90A-1o9gA:
0.0
4z90B-1o9gA:
0.0
4z90C-1o9gA:
0.0
4z90D-1o9gA:
0.0
4z90E-1o9gA:
0.0		 4z90A-1o9gA:
24.11
4z90B-1o9gA:
24.11
4z90C-1o9gA:
24.11
4z90D-1o9gA:
24.11
4z90E-1o9gA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 7 LEU A  69
ALA A  43
ALA A 211
LEU A  65
ALA A  36
 None
 1.08A 4z90F-1o9gA:
undetectable
4z90G-1o9gA:
undetectable
4z90H-1o9gA:
undetectable
4z90J-1o9gA:
undetectable		 4z90F-1o9gA:
24.11
4z90G-1o9gA:
24.11
4z90H-1o9gA:
24.11
4z90J-1o9gA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 7 LEU A  69
LEU A  55
ALA A 211
LEU A  65
ALA A  36
 None
 1.15A 4z90F-1o9gA:
undetectable
4z90G-1o9gA:
undetectable
4z90H-1o9gA:
undetectable
4z90J-1o9gA:
undetectable		 4z90F-1o9gA:
24.11
4z90G-1o9gA:
24.11
4z90H-1o9gA:
24.11
4z90J-1o9gA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		3 / 3 LYS A   2
ARG A   5
HIS A   6
 None
 0.99A 4zbrA-1o9gA:
0.0		 4zbrA-1o9gA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 4 ASP A  57
GLY A  61
ASP A  84
ASP A 153
 None
 0.73A 5e72A-1o9gA:
15.9		 5e72A-1o9gA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 7 GLY A  61
SER A  62
ASP A 153
ASP A  57
 None
 0.82A 5ergB-1o9gA:
12.2		 5ergB-1o9gA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1o9g RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 5 VAL A 238
LEU A 197
VAL A 154
LEU A 204
 None
 0.95A 6bqgA-1o9gA:
undetectable		 6bqgA-1o9gA:
12.13