SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		5 / 11 LEU A  80
GLY A  78
ILE A  77
SER A  74
ILE A  73
 None
 0.83A 2kawA-1o9iA:
undetectable		 2kawA-1o9iA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		5 / 12 LEU A 118
ASN A 119
LEU A  29
GLY A  30
MET A  39
 None
 1.23A 2q7lA-1o9iA:
undetectable		 2q7lA-1o9iA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		5 / 12 LEU A 118
ASN A 119
LEU A  29
GLY A  30
MET A  67
 None
 1.17A 2q7lA-1o9iA:
undetectable		 2q7lA-1o9iA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		5 / 12 GLY A  38
GLY A  63
PHE A 185
HIS A 181
HIS A  69
 None
None
None
MN3  A 268 ( 3.2A)
MN3  A 267 ( 3.3A)
 1.24A 2y7kC-1o9iA:
undetectable		 2y7kC-1o9iA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IT4_C_BEZC503_0
(ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		4 / 4 ARG A 177
GLN A 184
LEU A  58
HIS A 181
 None
None
None
MN3  A 268 ( 3.2A)
 1.28A 3it4C-1o9iA:
0.0		 3it4C-1o9iA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		4 / 5 ARG A 147
LEU A  29
SER A  28
MET A  67
 MN3  A 268 (-4.3A)
None
None
None
 1.04A 4e1gA-1o9iA:
undetectable		 4e1gA-1o9iA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		5 / 12 GLU A 150
GLY A  31
LEU A 158
ILE A  77
ARG A 157
 None
 1.03A 4hytA-1o9iA:
0.0		 4hytA-1o9iA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		5 / 12 GLU A 178
GLU A 150
GLY A  31
LEU A 158
ARG A 157
 None
 0.98A 4hytA-1o9iA:
0.0		 4hytA-1o9iA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		5 / 12 GLU A 150
GLY A  31
LEU A 158
ILE A  77
ARG A 157
 None
 1.02A 4hytC-1o9iA:
0.0		 4hytC-1o9iA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		5 / 12 GLU A 178
GLU A 150
GLY A  31
LEU A 158
ARG A 157
 None
 0.95A 4hytC-1o9iA:
0.0		 4hytC-1o9iA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		3 / 3 GLY A  31
GLU A  35
THR A  36
 None
MN3  A 267 (-2.6A)
None
 0.48A 4kouA-1o9iA:
undetectable		 4kouA-1o9iA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		4 / 5 GLU A 148
ALA A 151
GLU A 178
GLU A  66
 MN3  A 268 ( 2.7A)
None
None
MN3  A 267 (-2.6A)
 1.09A 5dwkC-1o9iA:
2.9		 5dwkC-1o9iA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		4 / 7 GLY A 222
GLY A 224
PHE A 228
LEU A 216
 None
 0.86A 5izfA-1o9iA:
undetectable		 5izfA-1o9iA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		5 / 12 LEU A 118
ASN A 119
LEU A  29
GLY A  30
GLY A  31
 None
 1.13A 5uc1B-1o9iA:
undetectable		 5uc1B-1o9iA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1o9i MANGANESE CATALASE
(Lactobacillus
plantarum) 		5 / 12 SER A 134
VAL A 145
GLY A  46
ALA A  48
GLU A 190
 None
 1.21A 6bqgA-1o9iA:
2.6		 6bqgA-1o9iA:
15.21