SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oa4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 1oa4 ENDO-BETA-1,4-GLUCAN
ASE
(Streptomyces
sp.
11AG8) 		5 / 12 TYR A  93
GLY A 129
LEU A 164
ALA A 102
TRP A 124
 None
 1.24A 1e3vA-1oa4A:
0.0		 1e3vA-1oa4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1oa4 ENDO-BETA-1,4-GLUCAN
ASE
(Streptomyces
sp.
11AG8) 		4 / 7 GLY A 208
GLY A  97
GLU A  40
ALA A  44
 None
 0.87A 3fpjB-1oa4A:
undetectable		 3fpjB-1oa4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 1oa4 ENDO-BETA-1,4-GLUCAN
ASE
(Streptomyces
sp.
11AG8) 		3 / 3 ARG A 118
GLU A 120
TYR A  66
 None
 0.83A 3k37B-1oa4A:
0.0		 3k37B-1oa4A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 1oa4 ENDO-BETA-1,4-GLUCAN
ASE
(Streptomyces
sp.
11AG8) 		4 / 5 ASP A 175
SER A  84
GLY A  83
ASP A 181
 None
 0.98A 3w9tC-1oa4A:
0.0		 3w9tC-1oa4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 1oa4 ENDO-BETA-1,4-GLUCAN
ASE
(Streptomyces
sp.
11AG8) 		4 / 5 PHE A  39
PHE A 202
ILE A  41
GLY A 210
 None
 0.95A 4ejjC-1oa4A:
undetectable		 4ejjC-1oa4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1oa4 ENDO-BETA-1,4-GLUCAN
ASE
(Streptomyces
sp.
11AG8) 		4 / 7 PRO A  54
SER A  56
VAL A 131
TRP A 205
 None
 1.32A 4kmmA-1oa4A:
0.0		 4kmmA-1oa4A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1oa4 ENDO-BETA-1,4-GLUCAN
ASE
(Streptomyces
sp.
11AG8) 		3 / 3 ARG A 146
TRP A 148
ILE A 169
 None
 1.01A 4mwxA-1oa4A:
undetectable		 4mwxA-1oa4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1oa4 ENDO-BETA-1,4-GLUCAN
ASE
(Streptomyces
sp.
11AG8) 		5 / 12 ASP A  62
TYR A  17
TYR A 103
LYS A 177
ILE A 105
 None
 1.27A 4ynpA-1oa4A:
undetectable		 4ynpA-1oa4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 1oa4 ENDO-BETA-1,4-GLUCAN
ASE
(Streptomyces
sp.
11AG8) 		5 / 12 LEU A 211
GLY A  97
GLY A 207
GLY A  46
ASN A  21
 None
 1.08A 6ce2B-1oa4A:
undetectable		 6ce2B-1oa4A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1oa4 ENDO-BETA-1,4-GLUCAN
ASE
(Streptomyces
sp.
11AG8) 		4 / 8 GLY A   9
THR A  12
ASN A  68
VAL A  18
 None
 0.80A 6czmD-1oa4A:
undetectable
6czmF-1oa4A:
undetectable		 6czmD-1oa4A:
20.51
6czmF-1oa4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 1oa4 ENDO-BETA-1,4-GLUCAN
ASE
(Streptomyces
sp.
11AG8) 		4 / 5 TYR A  93
ASN A 214
ARG A  92
PHE A 202
 None
 1.45A 6h3dA-1oa4A:
undetectable		 6h3dA-1oa4A:
19.45