SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oaa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
4 / 6 VAL A  40
MET A  38
ILE A  99
ASN A 101
None
None
None
NAP  A 800 (-3.3A)
0.94A 1e06A-1oaaA:
0.4
1e06A-1oaaA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
4 / 8 LEU A  28
ARG A  22
PHE A  20
GLY A  19
None
None
None
NAP  A 800 (-3.4A)
1.04A 1fapB-1oaaA:
undetectable
1fapB-1oaaA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
3 / 3 ILE A  99
ILE A 156
THR A 152
None
NAP  A 800 (-4.1A)
None
0.62A 1rg7A-1oaaA:
2.1
1rg7A-1oaaA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 12 ASN A 101
GLY A  15
ARG A  43
ALA A 103
THR A 104
NAP  A 800 (-3.3A)
NAP  A 800 (-3.2A)
NAP  A 800 (-3.4A)
NAP  A 800 (-3.2A)
NAP  A 800 ( 4.7A)
1.15A 2axnA-1oaaA:
undetectable
2axnA-1oaaA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
6 / 12 VAL A 153
LEU A 140
PHE A 251
GLY A 254
ALA A 186
LEU A 185
None
1.18A 2aylA-1oaaA:
undetectable
2aylA-1oaaA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 12 LEU A 127
GLY A  76
ASP A  70
ALA A  69
ALA A  67
NAP  A 800 (-4.2A)
SO4  A 802 (-3.4A)
NAP  A 800 ( 2.8A)
SO4  A 802 ( 4.1A)
None
1.18A 2br4E-1oaaA:
5.9
2br4E-1oaaA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 12 LEU A 170
LEU A 127
ALA A 103
ARG A  43
LEU A 209
None
NAP  A 800 (-4.2A)
NAP  A 800 (-3.2A)
NAP  A 800 (-3.4A)
None
1.42A 2oaxD-1oaaA:
undetectable
2oaxD-1oaaA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 12 LEU A 170
LEU A 127
ALA A 103
ARG A  43
LEU A 209
None
NAP  A 800 (-4.2A)
NAP  A 800 (-3.2A)
NAP  A 800 (-3.4A)
None
1.40A 2oaxE-1oaaA:
undetectable
2oaxE-1oaaA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
4 / 5 LEU A 226
ARG A 211
ASP A 229
ALA A 231
None
1.01A 2qhfA-1oaaA:
undetectable
2qhfA-1oaaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
3 / 3 MET A 206
CYH A 160
PRO A 199
OAA  A   1 ( 3.5A)
OAA  A   1 ( 3.9A)
NAP  A 800 (-4.1A)
0.89A 3h52C-1oaaA:
undetectable
3h52C-1oaaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 12 VAL A 153
LEU A 140
GLY A 254
ALA A 186
LEU A 185
None
1.19A 3pghA-1oaaA:
undetectable
3pghA-1oaaA:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HWK_A_SFYA807_0
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
9 / 11 SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
MET A 206
GLN A 207
ALA A 210
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.5A)
OAA  A   1 ( 3.6A)
OAA  A   1 (-3.5A)
0.29A 4hwkA-1oaaA:
42.1
4hwkA-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
10 / 11 LEU A 105
SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
MET A 206
GLN A 207
ALA A 210
OAA  A   1 (-4.0A)
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.5A)
OAA  A   1 ( 3.6A)
OAA  A   1 (-3.5A)
0.30A 4hwkB-1oaaA:
42.2
4hwkB-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
10 / 12 LEU A 105
SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
MET A 206
GLN A 207
ALA A 210
OAA  A   1 (-4.0A)
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.5A)
OAA  A   1 ( 3.6A)
OAA  A   1 (-3.5A)
0.29A 4hwkC-1oaaA:
42.2
4hwkC-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
10 / 11 LEU A 105
SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
MET A 206
GLN A 207
ALA A 210
OAA  A   1 (-4.0A)
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.5A)
OAA  A   1 ( 3.6A)
OAA  A   1 (-3.5A)
0.28A 4hwkD-1oaaA:
42.3
4hwkD-1oaaA:
72.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 12 LEU A  87
VAL A  84
LEU A  97
LEU A  96
LEU A 135
None
1.11A 4i1rA-1oaaA:
4.2
4i1rA-1oaaA:
23.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7U_A_YTZA802_1
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
8 / 10 SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
MET A 206
GLN A 207
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.5A)
OAA  A   1 ( 3.6A)
0.29A 4j7uA-1oaaA:
42.0
4j7uA-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7U_B_YTZB802_1
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
8 / 10 SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
MET A 206
GLN A 207
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.5A)
OAA  A   1 ( 3.6A)
0.29A 4j7uB-1oaaA:
42.1
4j7uB-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7U_C_YTZC802_1
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
8 / 10 SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
MET A 206
GLN A 207
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.5A)
OAA  A   1 ( 3.6A)
0.28A 4j7uC-1oaaA:
42.1
4j7uC-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
7 / 8 SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
GLN A 207
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.6A)
0.29A 4j7uD-1oaaA:
42.1
4j7uD-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
8 / 12 SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
GLN A 207
ALA A 210
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.6A)
OAA  A   1 (-3.5A)
0.35A 4j7xA-1oaaA:
42.1
4j7xA-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 12 SER A 158
LEU A 159
PRO A 201
GLN A 207
ASP A 216
OAA  A   1 (-2.5A)
None
None
OAA  A   1 ( 3.6A)
None
0.97A 4j7xA-1oaaA:
42.1
4j7xA-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
9 / 12 SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
GLN A 207
ALA A 210
LEU A 223
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.6A)
OAA  A   1 (-3.5A)
None
0.36A 4j7xB-1oaaA:
42.1
4j7xB-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 12 SER A 158
LEU A 159
CYH A 160
TYR A 171
LEU A 219
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
OAA  A   1 ( 4.3A)
None
1.04A 4j7xB-1oaaA:
42.1
4j7xB-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
8 / 12 SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
GLN A 207
ASP A 216
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.6A)
None
0.47A 4j7xF-1oaaA:
42.1
4j7xF-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 12 SER A 158
LEU A 159
PRO A 201
GLN A 207
ASP A 216
OAA  A   1 (-2.5A)
None
None
OAA  A   1 ( 3.6A)
None
1.02A 4j7xF-1oaaA:
42.1
4j7xF-1oaaA:
72.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
9 / 12 LEU A 105
SER A 158
LEU A 159
CYH A 160
TRP A 168
TYR A 171
PRO A 201
GLN A 207
ASP A 216
OAA  A   1 (-4.0A)
OAA  A   1 (-2.5A)
None
OAA  A   1 ( 3.9A)
None
OAA  A   1 ( 4.3A)
None
OAA  A   1 ( 3.6A)
None
0.36A 4j7xJ-1oaaA:
42.3
4j7xJ-1oaaA:
72.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 9 VAL A 153
LEU A 140
GLY A 254
ALA A 186
LEU A 185
None
1.12A 4rs0A-1oaaA:
0.0
4rs0A-1oaaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
3 / 3 SER A  33
ALA A   9
VAL A  10
None
0.56A 4x20C-1oaaA:
7.4
4x20C-1oaaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 9 ALA A 239
LEU A  32
LEU A 243
LEU A  28
ARG A  30
None
1.46A 4x30A-1oaaA:
0.0
4x30A-1oaaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
4 / 8 ILE A  99
ARG A  22
LEU A  55
MET A  38
None
0.99A 4xtaB-1oaaA:
undetectable
4xtaB-1oaaA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 11 SER A 131
THR A 130
ALA A 119
ASP A  70
GLY A  76
None
None
None
NAP  A 800 ( 2.8A)
SO4  A 802 (-3.4A)
1.39A 4zjoD-1oaaA:
0.0
4zjoD-1oaaA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
5 / 9 LEU A  13
GLY A  21
LEU A  24
LEU A 242
ALA A 239
None
1.06A 5dqfA-1oaaA:
undetectable
5dqfA-1oaaA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
4 / 8 ILE A  99
LEU A 245
ILE A 156
THR A 152
None
None
NAP  A 800 (-4.1A)
None
0.73A 5uihA-1oaaA:
undetectable
5uihA-1oaaA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
4 / 4 SER A  17
THR A 104
ASP A 107
ASP A 205
NAP  A 800 (-2.2A)
NAP  A 800 ( 4.7A)
None
NAP  A 800 (-2.2A)
1.49A 5vimA-1oaaA:
undetectable
5vimA-1oaaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
4 / 4 SER A  17
THR A 104
ASP A 107
ASP A 205
NAP  A 800 (-2.2A)
NAP  A 800 ( 4.7A)
None
NAP  A 800 (-2.2A)
1.45A 5vimB-1oaaA:
4.2
5vimB-1oaaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)
1oaa SEPIAPTERIN
REDUCTASE

(Mus
musculus)
4 / 6 LEU A 223
GLN A 207
LEU A 209
LEU A 105
None
OAA  A   1 ( 3.6A)
None
OAA  A   1 (-4.0A)
1.14A 5yvnA-1oaaA:
undetectable
5yvnA-1oaaA:
22.83