SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1obb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 10 ILE A 247
VAL A 262
TRP A 224
LEU A 221
TYR A 250
 None
 1.49A 1s1uA-1obbA:
0.4		 1s1uA-1obbA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 8 ILE A 461
ILE A 464
ILE A 438
ASN A 125
 None
 0.53A 2nniA-1obbA:
undetectable		 2nniA-1obbA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 ALA A 287
GLY A 281
VAL A 262
SER A 118
ASN A 236
 None
 1.05A 2okcA-1obbA:
4.4		 2okcA-1obbA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 4 SER A 265
TRP A 279
ASP A 222
ILE A 225
 None
 1.44A 2oxtD-1obbA:
4.0		 2oxtD-1obbA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		3 / 3 LEU A 187
TRP A 196
TYR A 218
 None
 1.01A 3aicF-1obbA:
undetectable		 3aicF-1obbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 8 GLY A 158
ILE A 155
ALA A 152
PHE A 173
 None
None
NAD  A 500 (-3.5A)
None
 0.97A 3aodA-1obbA:
undetectable		 3aodA-1obbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		3 / 3 GLU A 343
LEU A 346
ASP A 347
 None
 0.25A 3ko0A-1obbA:
undetectable		 3ko0A-1obbA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		3 / 3 GLU A 343
LEU A 346
ASP A 347
 None
 0.14A 3ko0T-1obbA:
undetectable		 3ko0T-1obbA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 10 VAL A 460
LEU A 445
GLY A 100
VAL A  96
GLY A 108
 None
 1.12A 3ls4H-1obbA:
undetectable		 3ls4H-1obbA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		6 / 9 ALA A  85
ILE A  40
GLY A  12
ILE A  48
VAL A  74
ILE A   9
 NAD  A 500 (-3.5A)
NAD  A 500 (-3.9A)
NAD  A 500 (-3.0A)
None
None
None
 1.47A 3nuoA-1obbA:
undetectable		 3nuoA-1obbA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 5 GLY A 281
LYS A 277
GLU A 282
GLY A 285
 None
 1.04A 3onnA-1obbA:
2.8		 3onnA-1obbA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		3 / 3 ARG A 425
VAL A 457
THR A 451
 None
 0.84A 3pwrA-1obbA:
undetectable		 3pwrA-1obbA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 6 ASP A  23
GLU A 354
GLY A 353
LEU A  20
 None
 1.08A 3w9tB-1obbA:
0.0		 3w9tB-1obbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 6 ASP A  23
GLU A 354
GLY A 353
LEU A  20
 None
 1.09A 3w9tE-1obbA:
0.0		 3w9tE-1obbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 6 ASP A  23
GLU A 354
GLY A 353
LEU A  20
 None
 1.09A 3w9tF-1obbA:
0.0		 3w9tF-1obbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 10 ARG A 164
ASP A 385
GLU A 427
GLU A 157
GLY A 158
 None
 1.21A 4evyA-1obbA:
0.3
4evyB-1obbA:
0.0		 4evyA-1obbA:
15.09
4evyB-1obbA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 8 GLY A  12
TYR A 296
LEU A 300
VAL A 303
 NAD  A 500 (-3.0A)
MAL  A 900 (-4.2A)
NAD  A 500 ( 4.9A)
None
 0.49A 4fgzA-1obbA:
4.0		 4fgzA-1obbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 8 GLY A  12
TYR A 296
LEU A 300
VAL A 303
 NAD  A 500 (-3.0A)
MAL  A 900 (-4.2A)
NAD  A 500 ( 4.9A)
None
 0.50A 4fgzB-1obbA:
4.0		 4fgzB-1obbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 5 SER A  33
LYS A   2
LEU A  63
ASP A  62
 None
 1.44A 4ifxA-1obbA:
0.0		 4ifxA-1obbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 5 SER A  33
LYS A   2
LEU A  63
ASP A  62
 None
 1.44A 4ig1A-1obbA:
0.0		 4ig1A-1obbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
GLY A  12
ASP A  39
ILE A  40
ALA A  85
 NAD  A 500 (-3.5A)
NAD  A 500 (-3.0A)
NAD  A 500 (-2.7A)
NAD  A 500 (-3.9A)
NAD  A 500 (-3.5A)
 0.72A 4iv8A-1obbA:
4.0		 4iv8A-1obbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
GLY A  12
ASP A  39
ILE A  40
ALA A  85
 NAD  A 500 (-3.5A)
NAD  A 500 (-3.0A)
NAD  A 500 (-2.7A)
NAD  A 500 (-3.9A)
NAD  A 500 (-3.5A)
 0.69A 4iv8B-1obbA:
3.8		 4iv8B-1obbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 8 LEU A  20
ILE A  48
ALA A  11
LEU A  37
 None
 0.79A 4qrcA-1obbA:
undetectable		 4qrcA-1obbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		3 / 3 PHE A 238
THR A  84
LEU A 300
 MAL  A 900 (-4.5A)
NAD  A 500 (-4.7A)
NAD  A 500 ( 4.9A)
 0.68A 4qztA-1obbA:
0.0		 4qztA-1obbA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		3 / 3 ARG A 422
GLU A 391
TYR A 418
 None
 0.91A 4r29D-1obbA:
0.0		 4r29D-1obbA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 LEU A 445
ILE A 438
ILE A 109
ILE A 464
MET A 473
 None
 1.07A 4rp8C-1obbA:
0.0		 4rp8C-1obbA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 THR A  84
ALA A 152
ALA A 151
ASN A 153
TYR A 296
 NAD  A 500 (-4.7A)
NAD  A 500 (-3.5A)
None
MAL  A 900 ( 3.1A)
MAL  A 900 (-4.2A)
 1.01A 4u15A-1obbA:
undetectable		 4u15A-1obbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 THR A  84
ALA A 152
ALA A 151
ASN A 153
TYR A 296
 NAD  A 500 (-4.7A)
NAD  A 500 (-3.5A)
None
MAL  A 900 ( 3.1A)
MAL  A 900 (-4.2A)
 1.13A 4u15B-1obbA:
undetectable		 4u15B-1obbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		3 / 3 SER A 143
ASP A  39
ASP A  72
 None
NAD  A 500 (-2.7A)
None
 0.72A 4uckA-1obbA:
3.0		 4uckA-1obbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 LEU A 242
SER A 243
LEU A 221
LEU A 207
ILE A 183
 None
 1.13A 4x1gA-1obbA:
0.0		 4x1gA-1obbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 5 SER A  33
LYS A   2
LEU A  63
ASP A  62
 None
 1.44A 4xdtA-1obbA:
0.0		 4xdtA-1obbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 6 GLU A 404
GLY A 259
ASP A 260
GLY A 179
 None
None
MAL  A 900 (-2.8A)
None
 0.95A 5cdpA-1obbA:
0.0
5cdpB-1obbA:
undetectable		 5cdpA-1obbA:
21.85
5cdpB-1obbA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 5 ALA A 217
TYR A 218
PRO A 408
GLY A 379
 None
 0.95A 5eslA-1obbA:
0.0		 5eslA-1obbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 ILE A 345
VAL A  35
ILE A  48
GLY A   7
LEU A 322
 None
 0.79A 5ienA-1obbA:
undetectable		 5ienA-1obbA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 ILE A 345
VAL A  35
ILE A  48
LEU A  37
LEU A 322
 None
 0.74A 5ienA-1obbA:
undetectable		 5ienA-1obbA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 10 ILE A 345
VAL A  35
ILE A  48
LEU A  37
LEU A 322
 None
 0.77A 5ienB-1obbA:
0.0		 5ienB-1obbA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 9 ILE A 345
VAL A  35
LEU A  37
ILE A   8
LEU A 322
 None
 1.04A 5iepA-1obbA:
0.0		 5iepA-1obbA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 8 TYR A 148
THR A 163
THR A 165
PRO A 154
 None
 0.96A 5jhdE-1obbA:
undetectable
5jhdG-1obbA:
0.0		 5jhdE-1obbA:
19.60
5jhdG-1obbA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 HIS A  90
SER A 334
VAL A 303
GLY A 301
ASP A 298
 NAD  A 500 (-4.2A)
None
None
None
None
 1.11A 5nnaA-1obbA:
undetectable		 5nnaA-1obbA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 HIS A  90
SER A 334
VAL A 303
GLY A 301
ASP A 298
 NAD  A 500 (-4.2A)
None
None
None
None
 1.15A 5nnaB-1obbA:
undetectable		 5nnaB-1obbA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 HIS A  90
SER A 334
VAL A 303
GLY A 301
ASP A 298
 NAD  A 500 (-4.2A)
None
None
None
None
 1.16A 5nnaC-1obbA:
undetectable		 5nnaC-1obbA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 HIS A  90
SER A 334
VAL A 303
GLY A 301
ASP A 298
 NAD  A 500 (-4.2A)
None
None
None
None
 1.11A 5nnaD-1obbA:
undetectable		 5nnaD-1obbA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 9 TYR A 218
ASP A 222
ALA A 246
ILE A 247
GLY A 254
 None
 1.33A 6awoA-1obbA:
undetectable		 6awoA-1obbA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 9 TYR A 218
ASP A 222
ALA A 246
ILE A 247
GLY A 254
 None
 1.33A 6awqA-1obbA:
undetectable		 6awqA-1obbA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 6 VAL A  35
LEU A  37
LEU A  49
LEU A  18
 None
 1.05A 6f6sA-1obbA:
0.0
6f6sB-1obbA:
undetectable		 6f6sA-1obbA:
11.70
6f6sB-1obbA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		3 / 3 VAL A 373
GLU A 391
ILE A 375
 None
 0.60A 6f7lB-1obbA:
1.8		 6f7lB-1obbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 8 ASP A 448
ILE A 109
ARG A 450
ASN A 125
 None
 1.08A 6hisA-1obbA:
undetectable
6hisB-1obbA:
undetectable		 6hisA-1obbA:
10.02
6hisB-1obbA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 8 ASP A 448
ILE A 109
ARG A 450
ASN A 125
 None
 1.08A 6hisB-1obbA:
undetectable
6hisC-1obbA:
0.0		 6hisB-1obbA:
10.02
6hisC-1obbA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 8 ASP A 448
ILE A 109
ARG A 450
ASN A 125
 None
 1.08A 6hisC-1obbA:
0.0
6hisD-1obbA:
undetectable		 6hisC-1obbA:
10.02
6hisD-1obbA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 8 ASP A 448
ILE A 109
ARG A 450
ASN A 125
 None
 1.07A 6hisD-1obbA:
undetectable
6hisE-1obbA:
0.0		 6hisD-1obbA:
10.02
6hisE-1obbA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 8 ASN A 125
ASP A 448
ILE A 109
ARG A 450
 None
 1.08A 6hisA-1obbA:
0.0
6hisE-1obbA:
0.0		 6hisA-1obbA:
10.02
6hisE-1obbA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 ILE A   9
GLY A  10
GLY A  12
ILE A  40
ASP A  41
 None
NAD  A 500 (-3.5A)
NAD  A 500 (-3.0A)
NAD  A 500 (-3.9A)
None
 0.68A 6iftA-1obbA:
2.7		 6iftA-1obbA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		5 / 12 ASN A 377
PRO A 376
ILE A 375
ILE A 381
PHE A 156
 None
 1.38A 6j21A-1obbA:
0.0		 6j21A-1obbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1obb ALPHA-GLUCOSIDASE
(Thermotoga
maritima) 		4 / 5 GLY A 158
LEU A 161
TYR A 148
GLN A 150
 None
 1.23A 6ji6A-1obbA:
0.1		 6ji6A-1obbA:
19.38