SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1obg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A  54
LEU A  57
THR A  58
VAL A  20
 None
None
None
SO4  A 311 (-3.4A)
 1.07A 1ekjF-1obgA:
undetectable
1ekjG-1obgA:
undetectable		 1ekjF-1obgA:
24.04
1ekjG-1obgA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  89
PRO A  90
LEU A  93
 None
 0.54A 1hrkA-1obgA:
undetectable		 1hrkA-1obgA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A69_C_RPTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 PHE A  33
ASP A  22
ARG A  38
SER A  40
ILE A  45
 AMP  A 307 (-4.8A)
None
None
None
None
 1.25A 2a69C-1obgA:
0.0
2a69F-1obgA:
0.0		 2a69C-1obgA:
14.55
2a69F-1obgA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 125
ARG A 122
ALA A 195
ASP A 215
PHE A 218
 None
SO4  A 308 (-2.9A)
None
SO4  A 308 ( 4.5A)
None
 1.10A 2ejtA-1obgA:
undetectable		 2ejtA-1obgA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  89
PRO A  90
LEU A  93
 None
 0.44A 2qd5B-1obgA:
undetectable		 2qd5B-1obgA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 102
ILE A  79
LEU A 108
LEU A  32
VAL A  26
 None
AMP  A 309 (-4.4A)
AMP  A 309 (-4.7A)
None
None
 0.86A 3adxB-1obgA:
undetectable		 3adxB-1obgA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  71
PHE A  67
SER A 200
 None
 0.61A 3i5uB-1obgA:
undetectable		 3i5uB-1obgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  89
PRO A  90
LEU A  93
 None
 0.46A 3w1wB-1obgA:
undetectable		 3w1wB-1obgA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  50
ILE A 293
TYR A 292
GLU A 294
 None
None
MG  A 310 (-4.4A)
None
 1.27A 4a99D-1obgA:
undetectable		 4a99D-1obgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 221
ARG A 190
GLU A 228
ARG A  73
 None
 0.98A 4bqfA-1obgA:
undetectable		 4bqfA-1obgA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 ARG A  21
SER A 128
ASP A 215
ARG A 122
GLU A 118
 SO4  A 311 ( 3.7A)
SO4  A 308 (-2.7A)
SO4  A 308 ( 4.5A)
SO4  A 308 (-2.9A)
None
 1.34A 4feuB-1obgA:
2.7
4feuE-1obgA:
4.1		 4feuB-1obgA:
21.91
4feuE-1obgA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 105
GLU A 103
PHE A  86
 None
 0.91A 4kszA-1obgA:
0.0		 4kszA-1obgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 275
LEU A 272
VAL A 278
 None
 0.49A 4wq4A-1obgA:
undetectable		 4wq4A-1obgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 171
ARG A 242
ARG A 122
 None
SO4  A 308 (-2.6A)
SO4  A 308 (-2.9A)
 0.96A 4x5iA-1obgA:
0.0		 4x5iA-1obgA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 182
VAL A 183
LEU A 187
VAL A 119
VAL A 121
PHE A 159
 None
 1.36A 4y0qA-1obgA:
undetectable		 4y0qA-1obgA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 125
VAL A 139
THR A 160
ASP A 215
ILE A 158
 None
None
None
SO4  A 308 ( 4.5A)
None
 1.46A 5lg3B-1obgA:
0.0		 5lg3B-1obgA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 125
VAL A 139
THR A 160
ASP A 215
ILE A 158
 None
None
None
SO4  A 308 ( 4.5A)
None
 1.42A 5lg3C-1obgA:
0.0		 5lg3C-1obgA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 125
VAL A 139
THR A 160
ASP A 215
ILE A 158
 None
None
None
SO4  A 308 ( 4.5A)
None
 1.45A 5lg3D-1obgA:
0.0		 5lg3D-1obgA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  56
LEU A  60
TRP A  64
 None
 0.90A 5nwuA-1obgA:
0.0		 5nwuA-1obgA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 112
ARG A  73
ILE A 230
 None
 0.53A 6fgdA-1obgA:
undetectable		 6fgdA-1obgA:
20.29