SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1obh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 PHE A  16
TRP A  13
GLU A 789
 None
 1.17A 1mogA-1obhA:
0.0		 1mogA-1obhA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 ALA A 325
VAL A 305
TRP A 323
 None
 0.88A 1nt5A-1obhA:
undetectable		 1nt5A-1obhA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 ALA A 325
VAL A 305
TRP A 323
 None
 0.88A 1nt5B-1obhA:
undetectable		 1nt5B-1obhA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_2
(GLUCOCORTICOID
RECEPTOR)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 4 LEU A 736
MET A  58
GLN A  69
TYR A  71
 None
 1.40A 1p93B-1obhA:
0.0		 1p93B-1obhA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 HIS A  49
GLY A  51
HIS A  52
GLY A 537
VAL A 577
 SO4  A1506 (-4.2A)
LMS  A1817 (-3.5A)
LMS  A1817 ( 4.3A)
LMS  A1817 ( 3.7A)
LMS  A1817 (-4.0A)
 0.82A 1pg2A-1obhA:
27.7		 1pg2A-1obhA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 HIS A  49
GLY A  51
HIS A  52
GLY A 538
VAL A 577
 SO4  A1506 (-4.2A)
LMS  A1817 (-3.5A)
LMS  A1817 ( 4.3A)
LMS  A1817 ( 4.1A)
LMS  A1817 (-4.0A)
 0.56A 1pg2A-1obhA:
27.7		 1pg2A-1obhA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 VAL A 444
ASP A 494
ASP A 496
TRP A 192
 None
 1.16A 1pk2A-1obhA:
undetectable		 1pk2A-1obhA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 PRO A 784
HIS A 785
LEU A 112
ILE A 117
 None
 1.09A 1sbrA-1obhA:
0.0
1sbrB-1obhA:
0.0		 1sbrA-1obhA:
12.30
1sbrB-1obhA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 TYR A 758
LEU A 721
LEU A 725
LEU A 714
ILE A 772
 None
 1.25A 1tw4B-1obhA:
undetectable		 1tw4B-1obhA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LEU A 141
LEU A 452
PHE A 502
MET A 498
 None
 0.87A 1wrlE-1obhA:
undetectable
1wrlF-1obhA:
undetectable		 1wrlE-1obhA:
6.82
1wrlF-1obhA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 304
ALA A 325
ASP A 326
ALA A 339
VAL A 260
 None
 0.99A 2b7zA-1obhA:
2.0		 2b7zA-1obhA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 304
ALA A 325
ASP A 326
ALA A 339
VAL A 260
 None
 1.01A 2b7zB-1obhA:
2.2		 2b7zB-1obhA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 LYS A 290
ASP A 347
ASP A 326
 None
NVA  A1818 (-3.1A)
None
 0.90A 2br4D-1obhA:
undetectable		 2br4D-1obhA:
14.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		7 / 8 MET A  40
TYR A  43
ASP A  80
SER A 504
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
NVA  A1816 ( 4.8A)
None
None
NVA  A1816 (-3.5A)
 0.50A 2bteA-1obhA:
38.5		 2bteA-1obhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		7 / 8 MET A  40
TYR A  43
ASP A  80
SER A 504
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
NVA  A1816 ( 4.8A)
None
None
NVA  A1816 (-3.5A)
 0.48A 2bteD-1obhA:
38.9		 2bteD-1obhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		6 / 7 MET A  40
TYR A  43
ASP A  80
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
None
None
NVA  A1816 (-3.5A)
 0.35A 2bytA-1obhA:
38.6		 2bytA-1obhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		6 / 7 MET A  40
TYR A  43
ASP A  80
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
None
None
NVA  A1816 (-3.5A)
 0.35A 2bytD-1obhA:
38.6		 2bytD-1obhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 LEU A 547
ILE A 196
ARG A 418
GLY A 225
 None
 0.92A 2du8A-1obhA:
undetectable		 2du8A-1obhA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 ASP A 251
SER A 386
VAL A 384
LEU A 373
 None
 1.05A 2hdnE-1obhA:
0.4
2hdnF-1obhA:
2.1
2hdnH-1obhA:
undetectable		 2hdnE-1obhA:
9.09
2hdnF-1obhA:
17.73
2hdnH-1obhA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 SER A 386
VAL A 384
LEU A 373
ASP A 251
 None
 1.04A 2hdnF-1obhA:
2.1
2hdnG-1obhA:
0.4
2hdnH-1obhA:
undetectable		 2hdnF-1obhA:
17.73
2hdnG-1obhA:
9.09
2hdnH-1obhA:
17.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		6 / 8 MET A  40
ASP A  80
SER A 504
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 (-3.9A)
NVA  A1816 ( 4.8A)
None
None
NVA  A1816 (-3.5A)
 0.61A 2v0gA-1obhA:
51.8		 2v0gA-1obhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		6 / 8 MET A  40
TYR A  43
ASP A  80
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
None
None
NVA  A1816 (-3.5A)
 0.41A 2v0gA-1obhA:
51.8		 2v0gA-1obhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 TYR A  43
ASP A  80
TYR A 507
TYR A 535
 NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
None
None
 0.34A 2v0gD-1obhA:
37.2		 2v0gD-1obhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 ARG A 602
PRO A 585
GLY A 584
TRP A 633
 None
 1.49A 2y7kB-1obhA:
0.0		 2y7kB-1obhA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 ARG A 602
PRO A 585
GLY A 584
TRP A 633
 None
 1.43A 2y7pA-1obhA:
0.0		 2y7pA-1obhA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 431
GLY A  83
PHE A 501
THR A 497
LEU A 473
 None
 1.21A 3dh0A-1obhA:
undetectable		 3dh0A-1obhA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 7 LEU A 473
ARG A 426
ARG A 428
PRO A  97
GLY A  83
 None
SO4  A1505 (-4.1A)
SO4  A1505 (-3.4A)
None
None
 1.31A 3hcrB-1obhA:
undetectable		 3hcrB-1obhA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 SER A 386
ASP A 390
ASP A 251
 None
 0.85A 3iv6A-1obhA:
undetectable		 3iv6A-1obhA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 ASP A 558
TYR A 199
VAL A 562
LEU A 509
 None
 1.16A 3jq7C-1obhA:
undetectable		 3jq7C-1obhA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 LEU A 556
PHE A 555
ILE A 139
PHE A 501
 None
 0.95A 3ko0B-1obhA:
undetectable		 3ko0B-1obhA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 LEU A 556
PHE A 555
ILE A 139
PHE A 501
 None
 0.96A 3ko0S-1obhA:
0.0		 3ko0S-1obhA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 4 LEU A 736
MET A  58
GLN A  69
TYR A  71
 None
 1.43A 3mneA-1obhA:
0.1		 3mneA-1obhA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 LEU A 736
MET A  58
GLN A  69
TYR A  71
 None
 1.42A 3mnoA-1obhA:
0.1		 3mnoA-1obhA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 LEU A 736
MET A  58
GLN A  69
TYR A  71
 None
 1.40A 3mnpA-1obhA:
0.1		 3mnpA-1obhA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 TYR A 508
PHE A 568
PRO A 567
LEU A 546
 None
 1.37A 3tgvC-1obhA:
0.0		 3tgvC-1obhA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 4 PRO A 531
LEU A  38
HIS A  75
LEU A 118
 None
 1.22A 3vw7A-1obhA:
0.0		 3vw7A-1obhA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 MET A  40
ASP A  80
SER A 504
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 (-3.9A)
NVA  A1816 ( 4.8A)
NVA  A1816 (-3.5A)
 0.42A 4aq7A-1obhA:
33.7		 4aq7A-1obhA:
45.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_D_LEUD902_0
(LEUCINE--TRNA LIGASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		6 / 9 MET A  40
ASP A  80
SER A 504
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 (-3.9A)
NVA  A1816 ( 4.8A)
None
None
NVA  A1816 (-3.5A)
 0.38A 4aq7D-1obhA:
45.4		 4aq7D-1obhA:
45.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 7 TYR A  43
ASP A  80
SER A 504
TYR A 535
HIS A 545
 NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
NVA  A1816 ( 4.8A)
None
NVA  A1816 (-3.5A)
 0.30A 4arcA-1obhA:
45.5		 4arcA-1obhA:
45.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 ILE A 536
GLY A 537
GLY A 538
PHE A 741
MET A  58
 None
LMS  A1817 ( 3.7A)
LMS  A1817 ( 4.1A)
None
None
 1.02A 4fakA-1obhA:
undetectable		 4fakA-1obhA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 ILE A 320
PRO A 321
GLY A 355
ALA A 339
 None
 0.96A 4g0uB-1obhA:
undetectable		 4g0uB-1obhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 GLY A 645
THR A 581
LEU A 578
ASN A 644
 None
 0.96A 4m5mA-1obhA:
undetectable		 4m5mA-1obhA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 ALA A 311
VAL A 305
GLY A 308
ALA A 309
ILE A 243
 None
 1.06A 4r21B-1obhA:
2.6		 4r21B-1obhA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 GLN A 710
GLU A 712
GLY A 723
ALA A 771
TYR A 722
 None
 1.41A 4rv6A-1obhA:
3.0		 4rv6A-1obhA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 GLN A 710
GLU A 712
GLY A 723
ALA A 771
TYR A 722
 None
 1.39A 4rv6B-1obhA:
undetectable		 4rv6B-1obhA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 THR A 127
ASP A 503
GLY A  83
TYR A  43
 None
None
None
NVA  A1816 ( 3.5A)
 0.97A 5hwaA-1obhA:
undetectable		 5hwaA-1obhA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 PRO A 520
HIS A 515
LEU A  28
TYR A  36
 None
 1.47A 5igjA-1obhA:
undetectable		 5igjA-1obhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 THR A 500
ALA A  81
THR A 127
GLU A 129
GLY A 431
 None
 1.14A 5lf3H-1obhA:
undetectable
5lf3I-1obhA:
undetectable		 5lf3H-1obhA:
13.47
5lf3I-1obhA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 THR A 500
ALA A  81
THR A 127
GLU A 129
GLY A 431
 None
 1.13A 5lf3V-1obhA:
undetectable
5lf3W-1obhA:
undetectable		 5lf3V-1obhA:
13.47
5lf3W-1obhA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 THR A 500
ALA A  81
THR A 127
GLU A 129
GLY A 431
 None
 1.13A 5lf7H-1obhA:
undetectable
5lf7I-1obhA:
undetectable		 5lf7H-1obhA:
13.47
5lf7I-1obhA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 ALA A 149
PHE A 140
THR A 497
ARG A 426
GLN A 427
 None
None
None
SO4  A1505 (-4.1A)
None
 1.25A 5m54B-1obhA:
undetectable		 5m54B-1obhA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 ALA A 149
PHE A 140
THR A 497
ARG A 426
GLN A 427
 None
None
None
SO4  A1505 (-4.1A)
None
 1.26A 5m54E-1obhA:
2.7		 5m54E-1obhA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 ILE A 117
LEU A 665
PHE A 741
ARG A  66
 None
 0.88A 5vc0A-1obhA:
undetectable		 5vc0A-1obhA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1obh LEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 PRO A  42
ILE A 105
GLY A  78
GLU A 124
 LMS  A1817 (-4.1A)
None
None
None
 0.93A 6gqiA-1obhA:
undetectable		 6gqiA-1obhA:
22.47