SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1of3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		4 / 6 TYR A  83
ASP A  81
ASN A 166
GLU A  38
 None
None
CA  A1174 ( 4.7A)
None
 0.91A 1rjdA-1of3A:
undetectable		 1rjdA-1of3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		4 / 6 TYR A  83
ASP A  81
ASN A 166
GLU A  38
 None
None
CA  A1174 ( 4.7A)
None
 0.91A 1rjdB-1of3A:
undetectable		 1rjdB-1of3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		4 / 6 TYR A  83
ASP A  81
ASN A 166
GLU A  38
 None
None
CA  A1174 ( 4.7A)
None
 0.92A 1rjdC-1of3A:
undetectable		 1rjdC-1of3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		5 / 12 TYR A  83
VAL A  52
ILE A  84
VAL A 151
LEU A  54
 None
 1.31A 1z9hA-1of3A:
undetectable		 1z9hA-1of3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		5 / 12 TYR A  83
VAL A  52
ILE A  84
VAL A 151
LEU A  54
 None
 1.31A 1z9hB-1of3A:
undetectable		 1z9hB-1of3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		5 / 12 TYR A  83
VAL A  52
ILE A  84
VAL A 151
LEU A  54
 None
 1.31A 1z9hC-1of3A:
undetectable		 1z9hC-1of3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		5 / 8 ILE A 164
ILE A  82
ILE A 122
ASN A 112
ALA A 119
 None
 1.06A 2nniA-1of3A:
undetectable		 2nniA-1of3A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		4 / 6 LEU A 147
LEU A 100
ILE A 149
ARG A  64
 None
 0.80A 2rlfA-1of3A:
undetectable
2rlfB-1of3A:
undetectable		 2rlfA-1of3A:
14.53
2rlfB-1of3A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		5 / 12 LEU A  54
VAL A 116
GLY A  92
PHE A 132
TYR A 158
 None
 1.32A 3medA-1of3A:
undetectable
3medB-1of3A:
undetectable		 3medA-1of3A:
14.99
3medB-1of3A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		5 / 12 LEU A  54
VAL A 116
GLY A  92
TYR A 158
GLU A  61
 None
 1.17A 3medA-1of3A:
undetectable
3medB-1of3A:
undetectable		 3medA-1of3A:
14.99
3medB-1of3A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		4 / 8 LEU A  94
LEU A 156
GLY A 153
VAL A  52
 None
 0.85A 4c9nA-1of3A:
undetectable		 4c9nA-1of3A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		4 / 7 TRP A  60
ASP A 154
SER A  58
HIS A 155
 None
 1.44A 4o4dA-1of3A:
undetectable		 4o4dA-1of3A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		5 / 12 TYR A  83
GLY A  44
LEU A  78
ARG A 135
HIS A 133
 None
CA  A1174 (-4.2A)
None
None
None
 1.12A 4wcxC-1of3A:
undetectable		 4wcxC-1of3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1of3 BETA-MANNOSIDASE
(Thermotoga
maritima) 		4 / 5 GLU A 146
SER A  25
ARG A  64
GLY A  26
 None
 0.99A 5kprA-1of3A:
undetectable		 5kprA-1of3A:
19.79