SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1of5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1of5 MRNA EXPORT FACTOR
MEX67
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 289
TRP A 292
LEU A 465
TRP A 449
 None
 1.35A 1ruaH-1of5A:
undetectable
1ruaL-1of5A:
0.0		 1ruaH-1of5A:
21.99
1ruaL-1of5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1of5 MRNA EXPORT FACTOR
MEX67
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 465
VAL A 458
SER A 280
ASN A 287
TYR A 303
 None
 1.45A 4amjB-1of5A:
undetectable		 4amjB-1of5A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1of5 MRNA EXPORT FACTOR
MEX67
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 389
VAL A 450
PRO A 453
ALA A 461
 None
 1.12A 5otrA-1of5A:
undetectable		 5otrA-1of5A:
21.19