SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ofe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A1481
VAL A1469
GLY A1477
VAL A1411
VAL A1393
 None
 1.30A 1akdA-1ofeA:
0.0		 1akdA-1ofeA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 8 ASP A1105
SER A1059
GLN A 969
GLY A1063
GLY A1106
 FMN  A2508 (-3.0A)
FMN  A2508 ( 3.9A)
AKG  A2510 ( 2.7A)
FMN  A2508 (-3.1A)
FMN  A2508 (-3.4A)
 1.49A 1aq7A-1ofeA:
undetectable		 1aq7A-1ofeA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLU A1381
ASP A1331
LEU A 331
LEU A 344
GLY A 348
 None
 1.29A 1d4fA-1ofeA:
undetectable		 1d4fA-1ofeA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 8 ALA A 587
LEU A 634
LEU A 629
LEU A 598
ALA A 638
 None
 1.36A 1e7cA-1ofeA:
undetectable		 1e7cA-1ofeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A1012
VAL A1033
ALA A1053
ILE A1056
ILE A1058
 None
 0.97A 1epbA-1ofeA:
undetectable		 1epbA-1ofeA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A1012
VAL A1033
ALA A1053
ILE A1056
ILE A1058
 None
 0.89A 1epbB-1ofeA:
undetectable		 1epbB-1ofeA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 4 LYS A 406
ALA A 409
MET A 293
 None
 1.07A 1hk3A-1ofeA:
undetectable		 1hk3A-1ofeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 ASN A 900
SER A1059
GLY A1063
GLY A1106
ASP A1105
 None
FMN  A2508 ( 3.9A)
FMN  A2508 (-3.1A)
FMN  A2508 (-3.4A)
FMN  A2508 (-3.0A)
 1.26A 1ho5B-1ofeA:
1.2		 1ho5B-1ofeA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLN A1017
ASP A1331
LEU A 331
SER A 366
 None
 1.25A 1ig3A-1ofeA:
undetectable
1ig3B-1ofeA:
0.3		 1ig3A-1ofeA:
10.88
1ig3B-1ofeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 418
TYR A 415
TYR A 413
TYR A 319
 None
 1.33A 1kiaC-1ofeA:
1.2		 1kiaC-1ofeA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 418
TYR A 415
TYR A 413
TYR A 319
 None
 1.32A 1kiaD-1ofeA:
0.0		 1kiaD-1ofeA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A1209
LEU A 846
LEU A 845
LEU A 481
TRP A1080
 None
 1.38A 1kw0A-1ofeA:
undetectable		 1kw0A-1ofeA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A 477
ASP A1062
LYS A 496
 None
 0.98A 1lqtB-1ofeA:
undetectable		 1lqtB-1ofeA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A 477
ASP A1062
LYS A 496
 None
 1.00A 1lquB-1ofeA:
undetectable		 1lquB-1ofeA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 ARG A 704
LEU A 545
GLU A 550
LEU A 541
ALA A 663
 None
 1.41A 1mjqC-1ofeA:
undetectable
1mjqD-1ofeA:
undetectable		 1mjqC-1ofeA:
5.63
1mjqD-1ofeA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 11 VAL A1280
LEU A1273
THR A1279
HIS A  30
GLU A 367
 None
 1.32A 1mmtA-1ofeA:
undetectable		 1mmtA-1ofeA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 11 ILE A 362
VAL A 392
VAL A 202
LEU A 384
ALA A 342
 None
 1.21A 1n4hA-1ofeA:
0.0		 1n4hA-1ofeA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 418
TYR A 415
TYR A 413
TYR A 319
 None
 1.33A 1nbhB-1ofeA:
0.7		 1nbhB-1ofeA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 418
TYR A 415
TYR A 413
TYR A 319
 None
 1.33A 1nbhD-1ofeA:
0.5		 1nbhD-1ofeA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 TYR A 911
ARG A 910
GLU A 906
TYR A 987
 None
 1.34A 1nx9B-1ofeA:
undetectable		 1nx9B-1ofeA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 TYR A 911
ARG A 910
GLU A 906
TYR A 987
 None
 1.33A 1nx9D-1ofeA:
undetectable		 1nx9D-1ofeA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 150
GLU A 143
LEU A 102
ARG A 146
GLU A 100
 None
 1.37A 1p5zB-1ofeA:
undetectable		 1p5zB-1ofeA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		6 / 12 PHE A 495
GLU A 764
ILE A 758
LEU A 737
PRO A 617
ILE A 616
 None
 1.38A 1qaoA-1ofeA:
undetectable		 1qaoA-1ofeA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLY A 341
MET A  47
ILE A 339
PRO A 288
 None
 1.06A 1rxcC-1ofeA:
undetectable		 1rxcC-1ofeA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 VAL A 599
ARG A 704
GLU A 548
ASP A 643
 None
 1.27A 1s3zA-1ofeA:
undetectable
1s3zB-1ofeA:
undetectable		 1s3zA-1ofeA:
8.93
1s3zB-1ofeA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 TYR A 188
ARG A  86
GLN A  81
 None
 1.02A 1tw4A-1ofeA:
3.6		 1tw4A-1ofeA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 5 ALA A 989
TYR A 987
ILE A 988
ASP A 907
 None
 1.15A 1upfC-1ofeA:
2.7		 1upfC-1ofeA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 ILE A 720
VAL A1048
ILE A1041
ILE A1056
 None
 0.82A 1uwhB-1ofeA:
undetectable		 1uwhB-1ofeA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		6 / 12 VAL A 296
ALA A 292
LEU A 224
HIS A 204
GLY A 225
SER A 366
 None
 1.43A 1uwjA-1ofeA:
undetectable		 1uwjA-1ofeA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU A 834
PHE A 870
LEU A1193
PHE A1127
 None
 1.02A 1wrlC-1ofeA:
undetectable
1wrlD-1ofeA:
undetectable		 1wrlC-1ofeA:
4.92
1wrlD-1ofeA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 LEU A1217
GLY A 736
LEU A 484
PRO A1079
 None
 0.88A 1ya4B-1ofeA:
undetectable		 1ya4B-1ofeA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A1481
VAL A1469
GLY A1477
VAL A1411
VAL A1393
 None
 1.31A 2cp4A-1ofeA:
0.0		 2cp4A-1ofeA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 866
LEU A1193
GLY A1111
ARG A 837
ILE A1177
 None
 1.27A 2e7fA-1ofeA:
7.5		 2e7fA-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A1056
LEU A1035
GLY A1047
SER A 208
ARG A 206
 None
None
None
None
ONL  A2511 (-4.0A)
 1.25A 2e7fA-1ofeA:
7.5		 2e7fA-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 866
LEU A1193
GLY A1111
ARG A 837
ILE A1177
 None
 1.25A 2e7fB-1ofeA:
7.9		 2e7fB-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A1056
LEU A1035
GLY A1047
SER A 208
ARG A 206
 None
None
None
None
ONL  A2511 (-4.0A)
 1.26A 2e7fB-1ofeA:
7.9		 2e7fB-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 MET A  76
LEU A 191
PRO A 126
TRP A 215
 None
 1.26A 2hrcA-1ofeA:
1.4		 2hrcA-1ofeA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A1108
ALA A1117
ASP A1105
ILE A1055
LEU A1101
 None
None
FMN  A2508 (-3.0A)
None
None
 1.09A 2jn3A-1ofeA:
2.0		 2jn3A-1ofeA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 150
GLU A 143
LEU A 102
ARG A 146
GLU A 100
 None
 1.28A 2no0A-1ofeA:
0.2		 2no0A-1ofeA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 150
GLU A 143
LEU A 102
ARG A 146
GLU A 100
 None
 1.29A 2no0B-1ofeA:
undetectable		 2no0B-1ofeA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 938
GLY A 931
ASP A 936
LEU A 926
SER A 923
 None
 1.35A 2nv4A-1ofeA:
undetectable		 2nv4A-1ofeA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 938
GLY A 931
ASP A 936
LEU A 926
SER A 923
 None
 1.23A 2nv4B-1ofeA:
0.0		 2nv4B-1ofeA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A1281
LEU A1365
GLY A1334
ILE A1360
ASN A1317
 None
 0.93A 2nxeA-1ofeA:
2.8		 2nxeA-1ofeA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 ARG A 498
ASN A 504
ASN A 268
LEU A 217
 None
 1.29A 2nyrA-1ofeA:
undetectable		 2nyrA-1ofeA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 866
LEU A1193
GLY A1111
ARG A 837
ILE A1177
 None
 1.25A 2ogyA-1ofeA:
7.5		 2ogyA-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A1056
LEU A1035
GLY A1047
SER A 208
ARG A 206
 None
None
None
None
ONL  A2511 (-4.0A)
 1.23A 2ogyA-1ofeA:
7.5		 2ogyA-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 866
LEU A1193
GLY A1111
ARG A 837
ILE A1177
 None
 1.23A 2ogyB-1ofeA:
7.9		 2ogyB-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A1056
LEU A1035
GLY A1047
SER A 208
ARG A 206
 None
None
None
None
ONL  A2511 (-4.0A)
 1.24A 2ogyB-1ofeA:
7.9		 2ogyB-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 5 SER A 947
GLY A 976
ASP A 327
ASP A 508
 None
 1.11A 2oxtB-1ofeA:
undetectable		 2oxtB-1ofeA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A1222
VAL A 753
ALA A1117
SER A1078
PRO A1079
 None
 1.37A 2vmyB-1ofeA:
2.2		 2vmyB-1ofeA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 LEU A 331
ASN A 227
GLU A 229
TYR A 203
 None
ONL  A2511 (-3.9A)
ONL  A2511 (-3.4A)
None
 1.26A 2w8yA-1ofeA:
0.0		 2w8yA-1ofeA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU A 580
VAL A 765
TYR A 492
GLN A 646
 None
 0.96A 2weyB-1ofeA:
undetectable		 2weyB-1ofeA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 150
GLU A 143
LEU A 102
ARG A 146
GLU A 100
 None
 1.28A 2ziaA-1ofeA:
undetectable		 2ziaA-1ofeA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A 602
THR A 556
GLU A 563
 None
 0.80A 2zifB-1ofeA:
undetectable		 2zifB-1ofeA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 ILE A1442
ARG A 511
MET A1424
THR A1425
 None
 1.17A 2zxwN-1ofeA:
0.0
2zxwW-1ofeA:
0.0		 2zxwN-1ofeA:
15.55
2zxwW-1ofeA:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 5 ILE A1442
ARG A 511
MET A1424
THR A1425
 None
 1.19A 3abkN-1ofeA:
0.0
3abkW-1ofeA:
0.0		 3abkN-1ofeA:
15.55
3abkW-1ofeA:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLY A1314
GLY A1336
GLY A1334
 None
 0.33A 3bogC-1ofeA:
undetectable		 3bogC-1ofeA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLY A 118
ASP A  37
SER A  35
 None
 0.69A 3brfA-1ofeA:
0.0		 3brfA-1ofeA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 668
ALA A 449
PHE A 773
ALA A 772
GLN A 675
 None
 1.16A 3bszF-1ofeA:
undetectable		 3bszF-1ofeA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A1385
GLY A1361
TYR A1366
ILE A1359
ARG A1378
 None
 1.40A 3bwyA-1ofeA:
undetectable		 3bwyA-1ofeA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A1373
ALA A1397
ALA A1429
GLY A1390
ILE A1360
 None
 1.07A 3c6gA-1ofeA:
undetectable		 3c6gA-1ofeA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 4 GLU A1081
GLY A1083
THR A1085
GLU A1086
 None
 1.08A 3e9xA-1ofeA:
0.0		 3e9xA-1ofeA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLY A1042
ILE A1056
VAL A1048
GLN A 501
 None
 0.86A 3fi0E-1ofeA:
undetectable		 3fi0E-1ofeA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 GLY A1042
ILE A1056
VAL A1048
GLN A 501
 None
 0.73A 3fi0G-1ofeA:
undetectable		 3fi0G-1ofeA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 GLY A1042
ILE A1056
VAL A1048
GLN A 501
 None
 0.77A 3fi0I-1ofeA:
undetectable		 3fi0I-1ofeA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A 587
LEU A 600
VAL A 564
ILE A 616
THR A 590
 None
 1.21A 3fl9C-1ofeA:
undetectable		 3fl9C-1ofeA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 ALA A 587
LEU A 600
VAL A 564
ILE A 616
THR A 590
 None
 1.13A 3fl9E-1ofeA:
undetectable		 3fl9E-1ofeA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 587
LEU A 600
VAL A 564
ILE A 616
THR A 590
 None
 1.09A 3fl9H-1ofeA:
undetectable		 3fl9H-1ofeA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A   2
GLY A   4
LEU A  25
MET A  28
GLN A1311
 None
 0.94A 3fzgA-1ofeA:
undetectable		 3fzgA-1ofeA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 991
GLY A 905
LEU A 877
ILE A 988
ALA A 879
 None
None
None
None
AKG  A2510 (-3.6A)
 1.05A 3gwvA-1ofeA:
0.0		 3gwvA-1ofeA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 LEU A1101
GLN A1057
LEU A1102
GLU A1124
 None
 1.08A 3h5gB-1ofeA:
undetectable
3h5gC-1ofeA:
undetectable		 3h5gB-1ofeA:
2.79
3h5gC-1ofeA:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 4 GLN A 467
PRO A 463
VAL A 462
GLU A 458
 None
 1.37A 3huoA-1ofeA:
0.0		 3huoA-1ofeA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 PHE A1316
TYR A1332
LEU A1284
 None
 0.70A 3keeB-1ofeA:
undetectable		 3keeB-1ofeA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ARG A 993
GLY A 951
GLY A1336
GLY A1367
SER A1312
 None
 1.00A 3kkzB-1ofeA:
undetectable		 3kkzB-1ofeA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL A 333
GLY A 341
VAL A  46
ILE A 362
GLY A   4
 None
 1.20A 3km6A-1ofeA:
undetectable		 3km6A-1ofeA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 GLY A 970
CYH A 871
PHE A 870
PHE A1174
 None
 0.98A 3ko0D-1ofeA:
undetectable
3ko0E-1ofeA:
undetectable		 3ko0D-1ofeA:
6.25
3ko0E-1ofeA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 GLY A 970
CYH A 871
PHE A 870
PHE A1174
 None
 0.97A 3ko0B-1ofeA:
0.0
3ko0J-1ofeA:
0.0		 3ko0B-1ofeA:
6.25
3ko0J-1ofeA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLY A 970
CYH A 871
PHE A 870
PHE A1174
 None
 0.96A 3ko0L-1ofeA:
undetectable
3ko0N-1ofeA:
undetectable		 3ko0L-1ofeA:
6.25
3ko0N-1ofeA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 GLY A 970
CYH A 871
PHE A 870
PHE A1174
 None
 0.92A 3ko0O-1ofeA:
undetectable
3ko0Q-1ofeA:
0.0		 3ko0O-1ofeA:
6.25
3ko0Q-1ofeA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLY A 970
CYH A 871
PHE A 870
PHE A1174
 None
 0.91A 3ko0M-1ofeA:
0.0
3ko0P-1ofeA:
1.4		 3ko0M-1ofeA:
6.25
3ko0P-1ofeA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLY A 970
CYH A 871
PHE A 870
PHE A1174
 None
 0.94A 3ko0K-1ofeA:
0.0
3ko0S-1ofeA:
0.0		 3ko0K-1ofeA:
6.25
3ko0S-1ofeA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLY A 970
CYH A 871
PHE A 870
PHE A1174
 None
 0.92A 3ko0R-1ofeA:
0.0
3ko0T-1ofeA:
undetectable		 3ko0R-1ofeA:
6.25
3ko0T-1ofeA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 HIS A1061
ASP A1062
ASP A 477
LEU A1219
GLU A1081
 None
 1.06A 3lmyA-1ofeA:
4.0		 3lmyA-1ofeA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 VAL A1385
VAL A1416
ILE A1410
ARG A 511
 None
 1.14A 3ms9A-1ofeA:
undetectable		 3ms9A-1ofeA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLY A 285
TRP A 252
VAL A 249
 None
 0.60A 3n62B-1ofeA:
undetectable		 3n62B-1ofeA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLY A 285
TRP A 252
VAL A 249
 None
 0.61A 3n65B-1ofeA:
undetectable		 3n65B-1ofeA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLY A 285
TRP A 252
VAL A 249
 None
 0.62A 3n66B-1ofeA:
undetectable		 3n66B-1ofeA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 HIS A 806
LEU A 888
GLY A1151
SER A 881
LEU A 880
 None
 1.08A 3n8xB-1ofeA:
undetectable		 3n8xB-1ofeA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 5 VAL A1181
LEU A1184
ILE A1196
ALA A1118
 None
 0.93A 3n8yB-1ofeA:
0.5		 3n8yB-1ofeA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 9 ARG A 949
GLU A 964
LEU A1015
LEU A1018
ILE A1009
 None
 1.46A 3nbqA-1ofeA:
undetectable		 3nbqA-1ofeA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 PHE A 334
ILE A 405
ILE A 362
ALA A   7
GLY A   4
 None
 0.97A 3nxuA-1ofeA:
0.0		 3nxuA-1ofeA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 5 PHE A  78
ILE A 155
MET A 221
PHE A 163
 None
 1.31A 3octA-1ofeA:
undetectable		 3octA-1ofeA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLN A 683
THR A 682
LEU A 700
 None
 0.68A 3ondA-1ofeA:
undetectable		 3ondA-1ofeA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLN A 683
THR A 682
LEU A 700
 None
 0.67A 3ondB-1ofeA:
undetectable		 3ondB-1ofeA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 TYR A 794
ASP A 844
ASP A 847
 None
 0.89A 3ou6B-1ofeA:
undetectable		 3ou6B-1ofeA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 PHE A1316
TYR A1332
LEU A1284
 None
 0.68A 3sueB-1ofeA:
undetectable		 3sueB-1ofeA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASN A1330
ALA A 368
ARG A 353
 None
 0.65A 3tj7C-1ofeA:
undetectable
3tj7D-1ofeA:
undetectable		 3tj7C-1ofeA:
9.39
3tj7D-1ofeA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A1122
LEU A1193
GLY A1198
HIS A1088
LEU A 846
 None
 1.33A 3tm4A-1ofeA:
4.9		 3tm4A-1ofeA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A1122
LEU A1193
GLY A1198
HIS A1088
LEU A 846
 None
 1.31A 3tm4B-1ofeA:
5.0		 3tm4B-1ofeA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLU A 258
LYS A 254
LYS A 245
GLU A 246
 None
 1.45A 4a7tA-1ofeA:
0.0		 4a7tA-1ofeA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLU A 258
LYS A 254
LYS A 245
GLU A 246
 None
 1.39A 4a7uA-1ofeA:
0.0		 4a7uA-1ofeA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 6 ILE A 390
VAL A 363
LEU A 373
ILE A 356
CYH A 355
 None
 1.25A 4asdA-1ofeA:
undetectable		 4asdA-1ofeA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 ARG A 353
GLU A1328
GLU A 367
ARG A  31
 None
 1.23A 4bqfB-1ofeA:
2.5		 4bqfB-1ofeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 VAL A1411
CYH A1401
CYH A1402
ILE A1394
 None
 1.20A 4bqtC-1ofeA:
undetectable
4bqtD-1ofeA:
undetectable		 4bqtC-1ofeA:
9.55
4bqtD-1ofeA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 11 PHE A1383
ALA A1375
GLY A1361
GLY A1380
ILE A1359
 None
 1.09A 4dcmA-1ofeA:
undetectable		 4dcmA-1ofeA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A1056
LEU A1035
GLY A1047
SER A 208
ARG A 206
 None
None
None
None
ONL  A2511 (-4.0A)
 1.23A 4djfB-1ofeA:
7.7		 4djfB-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 5 VAL A 909
ARG A 910
GLU A 906
LEU A 991
 None
 1.40A 4hojA-1ofeA:
0.0		 4hojA-1ofeA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU A1488
LEU A1481
ILE A1452
VAL A1411
 None
 0.65A 4klaA-1ofeA:
1.3		 4klaA-1ofeA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 8 PRO A1496
SER A1498
VAL A1420
GLY A1421
MET A1424
 None
 1.22A 4klrB-1ofeA:
3.5		 4klrB-1ofeA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 HIS A 627
VAL A 761
LEU A 741
 None
 0.69A 4m2vA-1ofeA:
undetectable		 4m2vA-1ofeA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 VAL A  46
TYR A 175
GLY A 185
ALA A 201
 None
 0.87A 4m48A-1ofeA:
undetectable		 4m48A-1ofeA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A1365
ALA A1392
ILE A1394
ALA A1375
ILE A1410
 None
 0.97A 4o2bD-1ofeA:
undetectable		 4o2bD-1ofeA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 ASN A1300
LEU A1284
MET A1337
ILE A1257
 None
 1.03A 4okwA-1ofeA:
undetectable		 4okwA-1ofeA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ASP A 336
LEU A 278
GLY A 225
MET A  47
PHE A 200
 None
 1.31A 4pgfA-1ofeA:
undetectable		 4pgfA-1ofeA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 4 THR A 172
GLY A 141
ASP A 142
SER A 169
 None
 1.38A 4rfqA-1ofeA:
2.4		 4rfqA-1ofeA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 11 GLY A1244
ILE A1025
ASN A1026
SER A1285
ASP A1249
 None
 1.49A 4rtrA-1ofeA:
undetectable		 4rtrA-1ofeA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 971
SER A1068
GLY A1128
GLN A 944
GLY A 902
 None
AKG  A2510 ( 4.7A)
FMN  A2508 (-3.4A)
FMN  A2508 (-2.9A)
FMN  A2508 ( 3.9A)
 1.15A 4uilH-1ofeA:
undetectable
4uilL-1ofeA:
undetectable		 4uilH-1ofeA:
9.45
4uilL-1ofeA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		6 / 12 GLY A1083
GLU A1086
LEU A1219
LEU A 845
ARG A1206
ALA A 841
 None
 1.49A 4wcxC-1ofeA:
7.8		 4wcxC-1ofeA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 580
GLY A 738
LEU A 737
ALA A 759
PHE A 746
 None
 1.03A 4wnwB-1ofeA:
0.0		 4wnwB-1ofeA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A 191
ASP A 190
LEU A  22
THR A  48
 None
 1.27A 4wozF-1ofeA:
5.3
4wozH-1ofeA:
7.2		 4wozF-1ofeA:
10.93
4wozH-1ofeA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 PRO A 604
VAL A 584
ASP A 578
ASN A 574
ILE A 616
 None
 1.14A 4xe0A-1ofeA:
undetectable		 4xe0A-1ofeA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 TYR A 827
VAL A 863
ILE A 866
LEU A1184
 None
 1.00A 4xo7A-1ofeA:
4.6		 4xo7A-1ofeA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 ARG A  52
ARG A  71
ASP A  68
ASP A  70
 None
 1.11A 4xqgA-1ofeA:
undetectable		 4xqgA-1ofeA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 ARG A  52
ARG A  71
ASP A  68
ASP A  70
 None
 1.12A 4xqgB-1ofeA:
undetectable		 4xqgB-1ofeA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 ARG A1160
SER A 881
PHE A1163
GLU A1135
 None
 1.23A 4xzkA-1ofeA:
undetectable		 4xzkA-1ofeA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLY A  41
ARG A 180
GLY A  33
GLU A  29
 None
 0.99A 4z2eB-1ofeA:
0.1
4z2eC-1ofeA:
undetectable		 4z2eB-1ofeA:
15.69
4z2eC-1ofeA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 491
PHE A 746
GLY A 623
LEU A 580
THR A 757
 None
 1.19A 4ze1A-1ofeA:
0.0		 4ze1A-1ofeA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 SER A 881
GLU A 883
GLY A1064
GLY A1128
 None
None
FMN  A2508 (-3.6A)
FMN  A2508 (-3.4A)
 0.91A 5cdnC-1ofeA:
0.0
5cdnD-1ofeA:
undetectable		 5cdnC-1ofeA:
16.24
5cdnD-1ofeA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 SER A 881
GLU A 883
GLY A1064
GLY A1128
 None
None
FMN  A2508 (-3.6A)
FMN  A2508 (-3.4A)
 0.90A 5cdnT-1ofeA:
3.6
5cdnU-1ofeA:
undetectable		 5cdnT-1ofeA:
16.24
5cdnU-1ofeA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 9 LEU A1481
VAL A1469
GLY A1477
VAL A1411
VAL A1393
 None
 1.34A 5cp4A-1ofeA:
0.0		 5cp4A-1ofeA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A  37
ARG A 206
ARG A 205
 None
ONL  A2511 (-4.0A)
None
 0.98A 5eajB-1ofeA:
0.0		 5eajB-1ofeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 11 THR A 425
LEU A 559
ALA A 536
GLN A 422
ILE A 419
 None
 1.44A 5ewjA-1ofeA:
2.9
5ewjB-1ofeA:
3.0		 5ewjA-1ofeA:
12.85
5ewjB-1ofeA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 THR A 425
LEU A 559
ALA A 536
GLN A 422
ILE A 419
 None
 1.38A 5ewjC-1ofeA:
undetectable
5ewjD-1ofeA:
undetectable		 5ewjC-1ofeA:
12.85
5ewjD-1ofeA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 9 TYR A 175
GLN A 130
ILE A 173
VAL A  74
LEU A 132
 None
 1.12A 5fxfA-1ofeA:
0.0		 5fxfA-1ofeA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 TYR A 175
GLN A 130
ILE A 173
VAL A  74
LEU A 132
 None
 1.14A 5fxfB-1ofeA:
3.7		 5fxfB-1ofeA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 977
GLY A 974
GLY A 948
SER A 947
HIS A1006
 AKG  A2510 (-3.2A)
None
None
None
None
 1.09A 5gwxA-1ofeA:
2.8		 5gwxA-1ofeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ARG A 992
GLY A 977
GLY A 974
GLY A 948
HIS A1006
 AKG  A2510 (-2.9A)
AKG  A2510 (-3.2A)
None
None
None
 1.10A 5hikA-1ofeA:
undetectable		 5hikA-1ofeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 977
GLY A 974
GLY A 948
SER A 947
HIS A1006
 AKG  A2510 (-3.2A)
None
None
None
None
 1.16A 5hikA-1ofeA:
undetectable		 5hikA-1ofeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A1452
GLY A1457
GLU A1434
ALA A1494
ILE A1465
 None
 1.21A 5igyA-1ofeA:
undetectable		 5igyA-1ofeA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A1452
GLY A1457
GLU A1434
ALA A1494
ILE A1465
 None
 1.20A 5ih0A-1ofeA:
0.0		 5ih0A-1ofeA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 LEU A 834
TYR A 794
SER A 798
 None
 0.84A 5iktA-1ofeA:
0.0		 5iktA-1ofeA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLY A1421
CYH A1402
CYH A1401
 None
 0.83A 5inzB-1ofeA:
undetectable		 5inzB-1ofeA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 965
HIS A1006
THR A1363
ALA A 968
ILE A1012
 None
 1.32A 5iwuA-1ofeA:
0.0		 5iwuA-1ofeA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 LYS A 803
LEU A 834
ILE A1130
 None
 0.74A 5kc4A-1ofeA:
undetectable		 5kc4A-1ofeA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A 642
ALA A 638
VAL A 625
GLY A 623
ALA A 621
 None
 0.94A 5kirA-1ofeA:
undetectable		 5kirA-1ofeA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A 642
ALA A 638
VAL A 625
GLY A 623
ALA A 621
 None
 0.93A 5kirB-1ofeA:
undetectable		 5kirB-1ofeA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 PRO A 488
GLU A 455
PHE A 783
GLY A 784
GLY A 792
 None
 1.18A 5l6eA-1ofeA:
undetectable		 5l6eA-1ofeA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLU A  29
LEU A  25
ARG A  31
ARG A 205
 None
 0.93A 5l6eA-1ofeA:
undetectable
5l6eB-1ofeA:
undetectable		 5l6eA-1ofeA:
9.67
5l6eB-1ofeA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 PRO A 544
ILE A 720
LEU A 711
VAL A 657
LEU A 656
 None
 1.16A 5tixB-1ofeA:
0.0		 5tixB-1ofeA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLY A 285
TRP A 252
VAL A 249
 None
 0.59A 5vuoB-1ofeA:
undetectable		 5vuoB-1ofeA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 8 GLY A 951
GLY A 905
GLU A 903
SER A 901
 None
None
AKG  A2510 (-4.0A)
None
 0.70A 5vw9A-1ofeA:
undetectable		 5vw9A-1ofeA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 543
ALA A 654
SER A 706
TYR A 703
CYH A 665
 None
 1.40A 5wbvA-1ofeA:
0.0		 5wbvA-1ofeA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 543
ALA A 654
SER A 706
TYR A 703
CYH A 665
 None
 1.41A 5wbvB-1ofeA:
0.0		 5wbvB-1ofeA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A  25
GLY A 177
PRO A 220
PRO A 216
GLU A 161
 None
 1.29A 5x6yC-1ofeA:
1.2		 5x6yC-1ofeA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A1365
ALA A1392
ILE A1394
ALA A1375
ILE A1410
 None
 1.01A 5xiwB-1ofeA:
undetectable		 5xiwB-1ofeA:
4.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A1365
ALA A1392
ILE A1394
ALA A1375
ILE A1410
 None
 0.95A 5xiwD-1ofeA:
undetectable		 5xiwD-1ofeA:
4.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 9 TYR A 956
ALA A 941
ILE A 942
GLY A 905
GLY A 960
 None
 1.27A 6awoA-1ofeA:
undetectable		 6awoA-1ofeA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 9 TYR A 956
ALA A 941
ILE A 942
GLY A 905
GLY A 960
 None
 1.28A 6awqA-1ofeA:
undetectable		 6awqA-1ofeA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 PHE A1352
ASN A1275
ALA A1308
ASP A1331
PRO A 351
 None
 1.17A 6b3aA-1ofeA:
undetectable		 6b3aA-1ofeA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 PHE A1352
ASN A1275
ALA A1308
ASP A1331
PRO A 351
 None
 1.17A 6b3bA-1ofeA:
3.2		 6b3bA-1ofeA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A 454
THR A 453
TYR A 452
PRO A 471
 None
 0.93A 6cduA-1ofeA:
0.0
6cduE-1ofeA:
0.0		 6cduA-1ofeA:
11.64
6cduE-1ofeA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 PRO A 471
ALA A 454
THR A 453
TYR A 452
 None
 0.94A 6cduH-1ofeA:
0.0
6cduI-1ofeA:
0.0		 6cduH-1ofeA:
11.64
6cduI-1ofeA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 TYR A 196
LEU A 191
ILE A 173
LEU A  17
ALA A 201
 None
 1.23A 6djzA-1ofeA:
undetectable		 6djzA-1ofeA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A1365
ASP A1008
ILE A1342
SER A1312
GLY A1314
 None
 1.47A 6dlzA-1ofeA:
1.5
6dlzD-1ofeA:
2.4		 6dlzA-1ofeA:
4.64
6dlzD-1ofeA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A1342
SER A1312
GLY A1314
LEU A1365
ASP A1008
 None
 1.47A 6dlzB-1ofeA:
2.4
6dlzC-1ofeA:
0.9		 6dlzB-1ofeA:
4.64
6dlzC-1ofeA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A1365
ASP A1008
ILE A1342
SER A1312
GLY A1314
 None
 1.48A 6dm1A-1ofeA:
0.9
6dm1D-1ofeA:
2.6		 6dm1A-1ofeA:
4.64
6dm1D-1ofeA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A1342
SER A1312
GLY A1314
LEU A1365
ASP A1008
 None
 1.48A 6dm1B-1ofeA:
2.7
6dm1C-1ofeA:
0.9		 6dm1B-1ofeA:
4.64
6dm1C-1ofeA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 VAL A 591
LEU A 598
LEU A 640
LEU A 583
 None
 0.98A 6f6sA-1ofeA:
0.0
6f6sB-1ofeA:
0.0		 6f6sA-1ofeA:
4.37
6f6sB-1ofeA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 ILE A 182
ALA A  44
MET A 178
ASP A  37
 None
 1.14A 6hu9m-1ofeA:
0.0
6hu9q-1ofeA:
0.0		 6hu9m-1ofeA:
16.88
6hu9q-1ofeA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 11 ILE A1410
ALA A1368
GLY A1334
PHE A1383
ALA A1379
 None
 1.29A 6ieyA-1ofeA:
undetectable
6ieyB-1ofeA:
undetectable		 6ieyA-1ofeA:
12.28
6ieyB-1ofeA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLY A 225
LEU A 332
SER A 271
GLN A 219
 None
None
ONL  A2511 (-3.2A)
ONL  A2511 (-4.3A)
 1.21A 6ji6A-1ofeA:
undetectable		 6ji6A-1ofeA:
9.91