SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ofh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 12 PHE A  78
ILE A  66
ALA A  67
ALA A  71
VAL A  27
 None
 1.00A 1cbsA-1ofhA:
undetectable		 1cbsA-1ofhA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		6 / 12 PHE A  78
ILE A  66
ALA A  67
ALA A  71
VAL A  27
LEU A 103
 None
 1.28A 2fr3A-1ofhA:
undetectable		 2fr3A-1ofhA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PY4_A_TYLA598_1
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.28A 3py4A-1ofhA:
0.0		 3py4A-1ofhA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		3 / 3 HIS A  16
ARG A  69
GLU A  12
 None
 0.86A 3qf1A-1ofhA:
0.0		 3qf1A-1ofhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA597_0
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.31A 3r4xA-1ofhA:
0.0		 3r4xA-1ofhA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA597_0
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.33A 3r55A-1ofhA:
0.0		 3r55A-1ofhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 7 LEU A  73
LEU A  13
GLU A   8
PRO A   6
ILE A   9
 None
 1.27A 3s56B-1ofhA:
undetectable		 3s56B-1ofhA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_A_MMZA616_1
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.23A 4ig5A-1ofhA:
0.0		 4ig5A-1ofhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_B_MMZB617_1
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.25A 4ig5B-1ofhA:
0.0		 4ig5B-1ofhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_D_3CJD607_1
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 4 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.33A 4qyqD-1ofhA:
0.0		 4qyqD-1ofhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		3 / 3 VAL A 278
LEU A 282
VAL A  96
 None
 0.52A 4wq4A-1ofhA:
undetectable		 4wq4A-1ofhA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA601_1
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.28A 5ff1A-1ofhA:
0.0		 5ff1A-1ofhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA602_1
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.28A 5ff1A-1ofhA:
0.0		 5ff1A-1ofhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB601_1
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.26A 5ff1B-1ofhA:
0.0		 5ff1B-1ofhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB613_1
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.26A 5ff1B-1ofhA:
0.0		 5ff1B-1ofhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.29A 5hpwA-1ofhA:
0.0		 5hpwA-1ofhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_D_3CJD609_1
(LACTOPEROXIDASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 4 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.33A 5hpwD-1ofhA:
0.0		 5hpwD-1ofhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		6 / 12 ILE A 253
GLY A 252
ALA A  71
ILE A  66
ALA A  67
VAL A  27
 None
 1.42A 5n0tB-1ofhA:
0.0		 5n0tB-1ofhA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 12 LEU A 327
PHE A 255
GLY A 252
ILE A 259
ALA A  83
 None
 0.90A 5veuH-1ofhA:
undetectable		 5veuH-1ofhA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 8 GLN A  20
GLY A  62
ILE A 344
GLN A 355
 None
ADP  A 450 (-3.3A)
ADP  A 450 ( 4.0A)
None
 0.94A 5vlmD-1ofhA:
undetectable		 5vlmD-1ofhA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 7 VAL A 254
PRO A  50
ILE A 100
THR A 104
 None
 0.83A 6cduF-1ofhA:
0.0
6cduG-1ofhA:
0.0		 6cduF-1ofhA:
22.32
6cduG-1ofhA:
22.32