SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ofu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 THR A 109
ASN A  44
THR A 102
GLY A  24
 GDP  A1318 (-4.1A)
GDP  A1318 ( 4.7A)
None
None
 0.98A 1bu5A-1ofuA:
5.6		 1bu5A-1ofuA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  18
ILE A  89
ALA A 113
GLY A 110
ALA A 114
ILE A 117
 None
None
None
GDP  A1318 (-3.5A)
None
None
 1.47A 1bx4A-1ofuA:
8.3		 1bx4A-1ofuA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		3 / 3 THR A 133
PRO A 165
THR A 163
 GDP  A1318 ( 4.9A)
None
None
 0.87A 1i3wE-1ofuA:
undetectable		 1i3wE-1ofuA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 192
ALA A 193
GLY A 227
PRO A 165
THR A 133
 None
None
None
None
GDP  A1318 ( 4.9A)
 0.94A 1k6cB-1ofuA:
undetectable		 1k6cB-1ofuA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 236
GLY A 268
ASP A 270
 None
 0.58A 1kf6A-1ofuA:
3.4
1kf6B-1ofuA:
undetectable		 1kf6A-1ofuA:
20.42
1kf6B-1ofuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1ofu CELL DIVISION
PROTEIN FTSZ
HYPOTHETICAL PROTEIN
PA3008
(Pseudomonas
aeruginosa) 		4 / 5 ILE X 102
SER A 272
ARG X  76
LEU X 103
 None
 1.06A 1y0xX-1ofuX:
undetectable		 1y0xX-1ofuX:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		3 / 3 THR A 163
THR A 133
PRO A 165
 None
GDP  A1318 ( 4.9A)
None
 0.88A 209dC-1ofuA:
undetectable		 209dC-1ofuA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  23
THR A 102
VAL A  16
ILE A  41
 None
 0.80A 2a1mB-1ofuA:
0.0		 2a1mB-1ofuA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 255
GLY A 227
ASN A 247
ALA A 244
ALA A 240
 None
 1.19A 2bm9C-1ofuA:
3.1		 2bm9C-1ofuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		3 / 3 LYS A  11
ASP A 199
ASP A 300
 None
 0.81A 2br4A-1ofuA:
3.2		 2br4A-1ofuA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 139
PHE A 183
ILE A 151
LEU A 154
GLY A 106
 GDP  A1318 (-2.8A)
GDP  A1318 (-3.8A)
None
None
GDP  A1318 ( 4.3A)
 1.31A 2e7fB-1ofuA:
2.7		 2e7fB-1ofuA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 8 THR A 228
GLY A 196
ASP A 199
THR A 266
 None
 0.88A 2f9wA-1ofuA:
2.2
2f9wB-1ofuA:
2.7		 2f9wA-1ofuA:
24.70
2f9wB-1ofuA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 GLU A  36
PRO A 204
ARG A 203
GLY A  37
 None
 1.26A 2hs1B-1ofuA:
undetectable		 2hs1B-1ofuA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 307
VAL A 295
GLY A 296
MET A 206
 None
 1.06A 2qd5B-1ofuA:
4.5		 2qd5B-1ofuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 113
GLY A  20
GLY A  23
ILE A  41
LEU A  59
 None
GDP  A1318 (-3.5A)
None
None
None
 0.91A 2z0yA-1ofuA:
3.4		 2z0yA-1ofuA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ofu HYPOTHETICAL PROTEIN
PA3008
(Pseudomonas
aeruginosa) 		5 / 12 PHE X  46
ALA X  45
THR X 128
ARG X 122
GLY X 151
 None
 1.34A 3aodC-1ofuX:
undetectable		 3aodC-1ofuX:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 8 VAL A 312
GLY A 315
THR A 314
GLY A 257
ALA A 258
 None
 1.38A 3aruA-1ofuA:
3.3		 3aruA-1ofuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 192
ALA A 193
GLY A 227
PRO A 165
THR A 133
 None
None
None
None
GDP  A1318 ( 4.9A)
 0.92A 3el9B-1ofuA:
undetectable		 3el9B-1ofuA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1318 (-3.5A)
GDP  A1318 (-3.4A)
None
None
None
 1.10A 3g88B-1ofuA:
3.8		 3g88B-1ofuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1318 (-3.5A)
GDP  A1318 (-3.4A)
None
None
None
 1.08A 3g89A-1ofuA:
3.9		 3g89A-1ofuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1318 (-3.5A)
GDP  A1318 (-3.4A)
None
None
None
 1.09A 3g89B-1ofuA:
3.9		 3g89B-1ofuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1318 (-3.5A)
GDP  A1318 (-3.4A)
None
None
None
 1.05A 3g8bA-1ofuA:
1.2		 3g8bA-1ofuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1318 (-3.5A)
GDP  A1318 (-3.4A)
None
None
None
 1.06A 3g8bB-1ofuA:
3.3		 3g8bB-1ofuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1ofu HYPOTHETICAL PROTEIN
PA3008
(Pseudomonas
aeruginosa) 		5 / 9 ALA X  95
LEU X  87
ILE X 158
LEU X 156
ILE X  65
 None
 1.29A 3jw3B-1ofuX:
undetectable		 3jw3B-1ofuX:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ofu CELL DIVISION
PROTEIN FTSZ
HYPOTHETICAL PROTEIN
PA3008
(Pseudomonas
aeruginosa) 		4 / 6 HIS X  89
VAL A 214
ILE A 299
LEU A 262
 None
 0.77A 3kk6A-1ofuX:
undetectable		 3kk6A-1ofuX:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  27
LEU A  50
GLY A  24
VAL A  19
GLY A  21
 None
None
None
None
GDP  A1318 (-3.3A)
 1.10A 3ls4H-1ofuA:
undetectable		 3ls4H-1ofuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 106
GLU A 139
GLY A 104
PRO A 135
 GDP  A1318 ( 4.3A)
GDP  A1318 (-2.8A)
GDP  A1318 (-3.1A)
GDP  A1318 ( 4.2A)
 1.01A 3onnA-1ofuA:
6.4		 3onnA-1ofuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 192
ALA A 193
PRO A 165
THR A 133
 None
None
None
GDP  A1318 ( 4.9A)
 0.73A 4eyrB-1ofuA:
undetectable		 4eyrB-1ofuA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 300
VAL A 309
ASN A  34
 None
 0.80A 4lmnA-1ofuA:
undetectable		 4lmnA-1ofuA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  49
ILE A  53
ASN A  52
ASN A  28
GLY A  24
 None
 1.28A 4obwD-1ofuA:
4.6		 4obwD-1ofuA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  71
GLY A  20
ILE A 151
MET A 105
GLY A 106
 GDP  A1318 ( 4.8A)
GDP  A1318 (-3.5A)
None
None
GDP  A1318 ( 4.3A)
 1.00A 4r29D-1ofuA:
0.0		 4r29D-1ofuA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ofu HYPOTHETICAL PROTEIN
PA3008
(Pseudomonas
aeruginosa) 		5 / 11 LEU X  78
ARG X 101
LEU X  80
ALA X  95
LEU X  92
 None
 1.18A 4wg0J-1ofuX:
undetectable
4wg0K-1ofuX:
undetectable
4wg0L-1ofuX:
undetectable		 4wg0J-1ofuX:
13.24
4wg0K-1ofuX:
13.24
4wg0L-1ofuX:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ofu HYPOTHETICAL PROTEIN
PA3008
(Pseudomonas
aeruginosa) 		5 / 11 ALA X  95
LEU X  92
LEU X  80
LEU X  78
ARG X 101
 None
 1.12A 4wg0I-1ofuX:
undetectable
4wg0J-1ofuX:
undetectable
4wg0K-1ofuX:
undetectable		 4wg0I-1ofuX:
13.24
4wg0J-1ofuX:
13.24
4wg0K-1ofuX:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  89
LEU A  83
ALA A 113
ILE A 117
 None
 0.80A 4y03A-1ofuA:
undetectable		 4y03A-1ofuA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 11 ASP A  85
VAL A  58
ILE A  41
ALA A 113
ILE A 117
 None
 1.16A 5gpgA-1ofuA:
undetectable		 5gpgA-1ofuA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
 GDP  A1318 (-3.5A)
None
None
None
None
None
 1.31A 5kb6A-1ofuA:
8.3		 5kb6A-1ofuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
 GDP  A1318 (-3.5A)
None
None
None
None
None
 1.32A 5kb6B-1ofuA:
7.7		 5kb6B-1ofuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 161
ILE A 126
THR A 128
MET A 124
 None
 1.28A 5ljeA-1ofuA:
0.0		 5ljeA-1ofuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 237
LEU A 307
VAL A 309
VAL A 263
GLY A 296
 None
 1.13A 5x24A-1ofuA:
undetectable		 5x24A-1ofuA:
19.42