SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ogo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		3 / 3 ASP X 154
ARG X 158
ILE X 135
 None
 0.81A 1a4gB-1ogoX:
undetectable		 1a4gB-1ogoX:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		4 / 6 GLN X 374
TYR X 303
VAL X  85
GLY X  88
 GLC  X1576 (-3.1A)
None
None
None
 1.22A 1ekjC-1ogoX:
undetectable
1ekjD-1ogoX:
undetectable		 1ekjC-1ogoX:
14.69
1ekjD-1ogoX:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 12 ILE X 526
LEU X 491
SER X 524
LEU X 536
ILE X 538
 None
 1.13A 1fmlB-1ogoX:
undetectable		 1fmlB-1ogoX:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 9 ALA X 397
ASP X 395
GLY X 458
ILE X 457
PRO X 489
 None
GLC  X1576 (-2.7A)
None
None
None
 1.05A 1hpvB-1ogoX:
undetectable		 1hpvB-1ogoX:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		6 / 12 ALA X 397
ASP X 395
GLY X 458
ILE X 457
PRO X 489
THR X 443
 None
GLC  X1576 (-2.7A)
None
None
None
None
 1.34A 1k6cB-1ogoX:
undetectable		 1k6cB-1ogoX:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 8 ILE X 139
ILE X 130
GLU X 163
VAL X 162
ILE X 149
 None
 1.48A 1linA-1ogoX:
undetectable		 1linA-1ogoX:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 12 ASP X 111
GLY X  48
VAL X 148
PHE X  52
ASN X  50
 None
 1.28A 1nw3A-1ogoX:
undetectable		 1nw3A-1ogoX:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		4 / 5 PRO X 132
VAL X 133
VAL X 483
ILE X 441
 None
 1.01A 1z2bC-1ogoX:
undetectable		 1z2bC-1ogoX:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		4 / 5 PRO X  93
GLY X  67
ASN X  77
GLY X  65
 None
 1.17A 1zlqA-1ogoX:
0.6		 1zlqA-1ogoX:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		3 / 3 ASP X 395
ILE X 421
VAL X 389
 GLC  X1576 (-2.7A)
None
None
 0.69A 2avvD-1ogoX:
undetectable		 2avvD-1ogoX:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 9 GLY X 377
GLU X 379
ASN X 348
ALA X 370
PHE X 373
 None
None
None
None
GLC  X1576 ( 4.1A)
 1.28A 2drdA-1ogoX:
undetectable		 2drdA-1ogoX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 9 ILE X  91
PHE X 171
HIS X 442
THR X 191
GLU X 189
 None
 1.34A 2dttE-1ogoX:
0.0
2dttF-1ogoX:
0.0		 2dttE-1ogoX:
10.51
2dttF-1ogoX:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		3 / 3 ASN X 499
ILE X 430
MET X 423
 None
 0.78A 2h42C-1ogoX:
undetectable		 2h42C-1ogoX:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 11 VAL X 440
ILE X 456
ILE X 400
ALA X 410
ILE X 412
 None
 0.74A 2idwA-1ogoX:
undetectable		 2idwA-1ogoX:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		4 / 7 ILE X 280
PRO X 208
GLY X 292
MET X 206
 None
 1.24A 2pnjB-1ogoX:
0.0		 2pnjB-1ogoX:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 11 ALA X 397
ASP X 395
GLY X 458
ILE X 457
PRO X 489
 None
GLC  X1576 (-2.7A)
None
None
None
 1.05A 2qhcA-1ogoX:
undetectable		 2qhcA-1ogoX:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 12 ILE X 494
ILE X 526
MET X 423
VAL X 479
VAL X 482
 None
 1.08A 2ygnA-1ogoX:
0.0		 2ygnA-1ogoX:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		6 / 12 ILE X 494
ILE X 526
PHE X 561
MET X 423
VAL X 479
VAL X 482
 None
 1.48A 2ygoA-1ogoX:
undetectable		 2ygoA-1ogoX:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		4 / 6 ILE X 280
ILE X 358
TYR X 381
LEU X 296
 None
 1.17A 3adsA-1ogoX:
0.0		 3adsA-1ogoX:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 8 GLY X 377
GLU X 379
ASN X 348
ALA X 370
PHE X 373
 None
None
None
None
GLC  X1576 ( 4.1A)
 1.14A 3aodA-1ogoX:
undetectable		 3aodA-1ogoX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		3 / 3 GLU X 485
SER X 161
VAL X 195
 None
 0.79A 3eeoA-1ogoX:
undetectable		 3eeoA-1ogoX:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		3 / 3 TYR X 106
TYR X 137
GLY X 157
 None
 0.67A 3eteB-1ogoX:
undetectable
3eteD-1ogoX:
undetectable
3eteF-1ogoX:
undetectable		 3eteB-1ogoX:
23.19
3eteD-1ogoX:
23.19
3eteF-1ogoX:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 12 VAL X 368
PRO X 345
PRO X 378
VAL X 389
ILE X 362
 None
 1.35A 4eb6B-1ogoX:
undetectable
4eb6C-1ogoX:
undetectable		 4eb6B-1ogoX:
21.63
4eb6C-1ogoX:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		4 / 5 SER X 460
GLU X 449
LYS X 447
ASP X 418
 None
BGC  X1575 (-3.1A)
BGC  X1575 (-2.9A)
GLC  X1576 (-4.1A)
 1.26A 4pclA-1ogoX:
undetectable		 4pclA-1ogoX:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		4 / 6 LYS X  39
SER X 161
VAL X 162
ASP X 167
 None
 1.11A 5hesA-1ogoX:
undetectable		 5hesA-1ogoX:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 9 ALA X 397
ASP X 395
GLY X 458
ILE X 457
PRO X 489
 None
GLC  X1576 (-2.7A)
None
None
None
 1.17A 5kr0A-1ogoX:
undetectable		 5kr0A-1ogoX:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		4 / 6 GLU X 299
ALA X 344
TYR X 275
SER X  60
 None
 1.13A 5phhA-1ogoX:
undetectable		 5phhA-1ogoX:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 12 GLY X 226
LEU X 261
THR X 265
VAL X 276
ILE X 223
 None
 1.36A 5tuiB-1ogoX:
undetectable		 5tuiB-1ogoX:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 12 LEU X 270
GLY X 292
GLY X 339
VAL X 338
MET X 210
 None
 1.03A 5uc1A-1ogoX:
undetectable		 5uc1A-1ogoX:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		5 / 12 GLY X  88
HIS X 416
SER X 320
GLN X 304
ASP X 317
 None
 1.39A 6bxlA-1ogoX:
undetectable		 6bxlA-1ogoX:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 1ogo DEXTRANASE
(Talaromyces
minioluteus) 		4 / 6 LEU X  46
THR X  49
GLY X  48
ARG X 150
 None
 1.16A 6gtqB-1ogoX:
0.0
6gtqD-1ogoX:
undetectable		 6gtqB-1ogoX:
13.82
6gtqD-1ogoX:
5.67