SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oh9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 5 LEU A  14
SER A 147
LEU A  80
GLY A  10
 None
NLG  A1260 ( 3.7A)
NLG  A1260 ( 4.7A)
ALF  A1261 ( 3.1A)
 0.81A 1a4lC-1oh9A:
undetectable		 1a4lC-1oh9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 12 LEU A 168
ALA A 174
LEU A  38
LEU A   9
ALA A 165
 None
 0.80A 1ao8A-1oh9A:
undetectable		 1ao8A-1oh9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 12 LEU A 168
ALA A 174
LEU A  38
LEU A   9
ALA A 165
 None
 0.99A 1bzfA-1oh9A:
undetectable		 1bzfA-1oh9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 7 ILE A 256
THR A 254
MET A 196
MET A 214
 None
None
None
ADP  A1259 (-4.5A)
 1.20A 1kglA-1oh9A:
undetectable		 1kglA-1oh9A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 6 ARG A 255
ILE A 177
ALA A 235
ALA A 194
 None
 0.85A 1w0gA-1oh9A:
undetectable		 1w0gA-1oh9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 12 LEU A 176
GLY A 173
VAL A  39
ILE A 133
ILE A   6
 None
 0.92A 2f8gB-1oh9A:
undetectable		 2f8gB-1oh9A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		3 / 3 LYS A  61
ARG A  66
ASP A 181
 NLG  A1260 ( 4.4A)
NLG  A1260 (-3.9A)
ADP  A1259 ( 4.9A)
 1.30A 3o7wA-1oh9A:
2.5		 3o7wA-1oh9A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 6 LEU A  38
PRO A 143
LEU A 168
LEU A 172
 None
 0.99A 3q1eA-1oh9A:
0.0
3q1eC-1oh9A:
0.0		 3q1eA-1oh9A:
14.83
3q1eC-1oh9A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 6 LEU A 168
LEU A 172
LEU A  38
PRO A 143
 None
 1.08A 3q1eA-1oh9A:
0.0
3q1eC-1oh9A:
0.0		 3q1eA-1oh9A:
14.83
3q1eC-1oh9A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 5 LEU A 142
ALA A  92
PHE A  24
ASN A  85
 None
 1.24A 3uq6A-1oh9A:
undetectable		 3uq6A-1oh9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 4 LEU A 142
ALA A  92
PHE A  24
ASN A  85
 None
 1.18A 3vaqA-1oh9A:
undetectable		 3vaqA-1oh9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 4 LEU A 142
ALA A  92
PHE A  24
ASN A  85
 None
 1.17A 3vasA-1oh9A:
undetectable		 3vasA-1oh9A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 10 GLY A 173
ALA A 174
ILE A   6
PRO A 143
ILE A 133
 None
 0.97A 4dt8B-1oh9A:
undetectable		 4dt8B-1oh9A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 8 GLY A 173
ALA A 174
ASP A 175
PRO A 143
 None
 0.80A 4eyrB-1oh9A:
undetectable		 4eyrB-1oh9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 7 LEU A 176
ARG A 226
SER A 180
VAL A 216
 None
None
ADP  A1259 (-4.6A)
None
 1.18A 4klrA-1oh9A:
3.7		 4klrA-1oh9A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 12 LEU A 102
VAL A 145
VAL A  41
LEU A 172
THR A 171
 None
 0.88A 4m2vA-1oh9A:
undetectable		 4m2vA-1oh9A:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 12 LEU A 102
VAL A 145
VAL A  41
LEU A 172
THR A 171
 None
 0.87A 4m2wA-1oh9A:
undetectable		 4m2wA-1oh9A:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 8 ALA A  84
VAL A  47
GLY A  82
ALA A  81
GLY A  78
 None
 1.48A 4zjzB-1oh9A:
2.1		 4zjzB-1oh9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 12 ALA A 161
GLY A  43
GLY A  11
LEU A  13
ALA A  81
 NLG  A1260 ( 3.2A)
NLG  A1260 ( 3.5A)
ADP  A1259 ( 3.8A)
None
None
 0.93A 5c0oG-1oh9A:
2.7		 5c0oG-1oh9A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 7 ILE A 256
THR A 254
MET A 196
MET A 214
 None
None
None
ADP  A1259 (-4.5A)
 1.21A 5ljcA-1oh9A:
undetectable		 5ljcA-1oh9A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 6 ILE A 256
THR A 254
MET A 196
MET A 214
 None
None
None
ADP  A1259 (-4.5A)
 1.22A 5ljeA-1oh9A:
undetectable		 5ljeA-1oh9A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 7 GLY A 123
ILE A 148
GLY A 149
LEU A 104
ILE A   6
 None
 1.25A 5vkqA-1oh9A:
undetectable
5vkqB-1oh9A:
undetectable		 5vkqA-1oh9A:
10.19
5vkqB-1oh9A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 8 LEU A 168
LEU A   9
VAL A  41
ILE A 133
LEU A 137
 None
 1.17A 5vkqB-1oh9A:
undetectable
5vkqC-1oh9A:
undetectable		 5vkqB-1oh9A:
10.19
5vkqC-1oh9A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 12 LEU A   9
VAL A  41
ARG A  36
ILE A   6
ASP A 175
 None
 1.18A 6bxmA-1oh9A:
undetectable		 6bxmA-1oh9A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 10 PHE A  24
LEU A  23
ILE A  97
ILE A  40
ILE A   7
 None
 1.03A 6ebpD-1oh9A:
undetectable		 6ebpD-1oh9A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 11 PHE A  24
LEU A  23
ILE A  97
ILE A  40
ILE A   7
 None
 1.05A 6ebzA-1oh9A:
undetectable		 6ebzA-1oh9A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 11 PHE A  24
LEU A  23
ILE A  97
ILE A  40
ILE A   7
 None
 1.03A 6ebzB-1oh9A:
undetectable		 6ebzB-1oh9A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 11 PHE A  24
LEU A  23
ILE A  97
ILE A  40
ILE A   7
 None
 1.04A 6ebzC-1oh9A:
undetectable		 6ebzC-1oh9A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 11 PHE A  24
LEU A  23
ILE A  97
ILE A  40
ILE A   7
 None
 1.06A 6ebzD-1oh9A:
undetectable		 6ebzD-1oh9A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		5 / 11 PHE A  24
LEU A  23
ILE A  97
ILE A  40
ILE A   7
 None
 1.05A 6gp2B-1oh9A:
undetectable		 6gp2B-1oh9A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 4 ASP A 106
ILE A 133
PRO A 130
LEU A 132
 None
 1.43A 6mkeB-1oh9A:
0.0		 6mkeB-1oh9A:
15.50