SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ohe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		3 / 3 GLN A 242
HIS A 231
PRO A 230
 None
 0.96A 1d8cA-1oheA:
undetectable		 1d8cA-1oheA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		4 / 6 GLY A 354
ASP A 167
GLY A 171
TYR A 170
 None
 0.96A 1eswA-1oheA:
undetectable		 1eswA-1oheA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		3 / 3 ILE A 177
ASP A  88
PHE A  89
 None
 0.46A 1uwjB-1oheA:
0.0		 1uwjB-1oheA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		4 / 4 VAL A 344
LEU A 283
ILE A 302
LEU A 300
 None
 0.88A 2byoA-1oheA:
undetectable		 2byoA-1oheA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		5 / 11 ILE A  52
THR A  53
ILE A 118
ASN A 105
ILE A 104
 None
 1.04A 3kpcA-1oheA:
undetectable		 3kpcA-1oheA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		4 / 7 TYR A 248
ASN A 217
LEU A 216
ASP A 215
 None
 1.41A 3lslA-1oheA:
undetectable
3lslD-1oheA:
undetectable		 3lslA-1oheA:
22.19
3lslD-1oheA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		4 / 7 TYR A 248
ASN A 217
LEU A 216
ASP A 215
 None
 1.40A 3lslA-1oheA:
undetectable
3lslD-1oheA:
undetectable		 3lslA-1oheA:
22.19
3lslD-1oheA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		4 / 6 TYR A 248
ASN A 217
LEU A 216
ASP A 215
 None
 1.35A 3lslG-1oheA:
undetectable		 3lslG-1oheA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A 166
PRO A  91
PHE A  89
 None
 0.97A 3thrC-1oheA:
0.2		 3thrC-1oheA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		3 / 3 SER A 124
GLY A 123
GLN A 129
 None
 0.58A 3v4tH-1oheA:
undetectable		 3v4tH-1oheA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		5 / 8 VAL A 312
LEU A 263
LEU A 324
ASP A 301
ILE A 302
 None
 1.19A 4lzrA-1oheA:
undetectable		 4lzrA-1oheA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		5 / 12 TYR A 268
ILE A 220
PHE A 299
HIS A 280
PHE A 227
 None
 1.17A 5fsaA-1oheA:
undetectable		 5fsaA-1oheA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		4 / 5 GLY A 371
ASP A 372
ARG A 334
MET A 362
 None
 1.30A 5gwkA-1oheA:
1.6		 5gwkA-1oheA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens) 		5 / 9 ILE A 346
GLY A  90
PHE A 134
ASN A 131
ALA A 168
 None
 1.29A 5x66C-1oheA:
undetectable		 5x66C-1oheA:
19.49