SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		3 / 3 ASP A  85
LYS A  58
ARG A  61
 None
 0.90A 1ra8A-1ohtA:
undetectable		 1ra8A-1ohtA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		5 / 8 GLY A  77
GLY A  98
ALA A  99
ILE A  40
HIS A  42
 None
None
EDO  A1186 (-4.0A)
None
ZN  A1185 (-3.2A)
 0.93A 1yajC-1ohtA:
undetectable		 1yajC-1ohtA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		5 / 12 LEU A 113
GLU A 168
ILE A 169
SER A 170
ILE A 134
 None
 1.09A 3cd2A-1ohtA:
undetectable		 3cd2A-1ohtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		5 / 11 ILE A 114
ASP A  85
ILE A 111
LEU A 133
THR A  53
 None
 1.00A 3clbA-1ohtA:
undetectable		 3clbA-1ohtA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		5 / 12 TYR A  78
GLY A  81
GLY A  91
SER A  79
HIS A  67
 None
 1.10A 3e23A-1ohtA:
undetectable		 3e23A-1ohtA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		3 / 3 LYS A 124
LEU A 165
ILE A  82
 None
 0.66A 5kc0A-1ohtA:
undetectable		 5kc0A-1ohtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		5 / 10 LEU A 113
HIS A  42
ILE A  82
GLY A  81
ALA A 130
 None
ZN  A1185 (-3.2A)
None
None
None
 0.97A 5o96C-1ohtA:
undetectable
5o96D-1ohtA:
undetectable		 5o96C-1ohtA:
22.83
5o96D-1ohtA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		4 / 8 VAL A 155
ARG A 156
HIS A 152
ILE A  40
 None
None
ZN  A1185 (-3.1A)
None
 0.80A 5v0vA-1ohtA:
undetectable		 5v0vA-1ohtA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		5 / 7 GLY A 162
LEU A 165
ILE A  41
GLY A 151
ILE A  76
 None
 1.02A 5vkqA-1ohtA:
undetectable
5vkqB-1ohtA:
undetectable		 5vkqA-1ohtA:
8.46
5vkqB-1ohtA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		5 / 8 GLY A 162
LEU A 165
ILE A  41
GLY A 151
ILE A  76
 None
 1.01A 5vkqB-1ohtA:
undetectable
5vkqC-1ohtA:
undetectable		 5vkqB-1ohtA:
8.46
5vkqC-1ohtA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		5 / 9 GLY A 162
LEU A 165
ILE A  41
GLY A 151
ILE A  76
 None
 0.97A 5vkqC-1ohtA:
0.0
5vkqD-1ohtA:
0.0		 5vkqC-1ohtA:
8.46
5vkqD-1ohtA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		5 / 12 SER A 108
ASN A 179
PHE A 175
GLY A 151
PHE A 166
 None
TLA  A1188 (-3.2A)
None
None
None
 1.35A 6dwnA-1ohtA:
undetectable		 6dwnA-1ohtA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1oht CG14704 PROTEIN
(Drosophila
melanogaster) 		5 / 12 ILE A 134
VAL A 138
ILE A  82
VAL A  39
PHE A  94
 None
 1.24A 6j21A-1ohtA:
undetectable		 6j21A-1ohtA:
16.71