SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oi7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 9 VAL A 204
GLY A 148
ALA A 160
THR A 171
ILE A 149
 None
 1.21A 1gtnL-1oi7A:
undetectable
1gtnM-1oi7A:
undetectable		 1gtnL-1oi7A:
14.98
1gtnM-1oi7A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 11 SER A 128
THR A 157
ILE A 206
ILE A 150
VAL A 204
 None
 1.19A 1pkvA-1oi7A:
undetectable
1pkvB-1oi7A:
undetectable		 1pkvA-1oi7A:
17.42
1pkvB-1oi7A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 11 ILE A 150
VAL A 204
SER A 128
THR A 157
ILE A 206
 None
 1.19A 1pkvA-1oi7A:
undetectable
1pkvB-1oi7A:
undetectable		 1pkvA-1oi7A:
17.42
1pkvB-1oi7A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 GLY A 179
GLU A 208
ASN A 122
 None
 0.62A 1zq9A-1oi7A:
5.2		 1zq9A-1oi7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 9 GLU A 214
ILE A 177
GLY A 178
GLY A 179
LEU A 205
 None
 1.15A 2qmmA-1oi7A:
2.2		 2qmmA-1oi7A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 THR A  24
ILE A  15
GLY A  20
PHE A  71
ILE A  69
 None
 1.37A 2y7wB-1oi7A:
2.1		 2y7wB-1oi7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 7 THR A  24
ILE A  15
GLY A  20
PHE A  71
ILE A  69
 None
 1.37A 2y7wC-1oi7A:
2.2		 2y7wC-1oi7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 THR A 185
ILE A 150
LEU A   3
ILE A   2
THR A 200
 None
 1.27A 3a50E-1oi7A:
undetectable		 3a50E-1oi7A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 THR A 186
SER A 212
LYS A 261
 None
 0.91A 3aocC-1oi7A:
undetectable		 3aocC-1oi7A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 ALA A 167
GLU A 159
THR A 174
ILE A 279
THR A 171
 None
 1.26A 3dl9B-1oi7A:
undetectable		 3dl9B-1oi7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 MET A 104
ILE A  89
ALA A  85
LEU A  82
VAL A  56
 None
 0.92A 3fpjA-1oi7A:
4.4		 3fpjA-1oi7A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 ILE A  95
ALA A  77
MET A 104
LEU A 118
ILE A 183
 None
 1.30A 3ia4B-1oi7A:
2.8		 3ia4B-1oi7A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 SER A 153
GLY A 154
THR A 155
 None
 0.15A 3k9wA-1oi7A:
3.2		 3k9wA-1oi7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 ILE A 206
SER A 153
ILE A 119
VAL A 229
PHE A 187
 None
 1.01A 3vw1D-1oi7A:
0.3		 3vw1D-1oi7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 7 LEU A 164
ILE A 206
THR A 174
GLY A 148
 None
 0.95A 4eq4A-1oi7A:
undetectable		 4eq4A-1oi7A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 TYR A 158
GLY A 125
GLY A 176
ILE A 127
ILE A 134
 None
 0.75A 4iv0A-1oi7A:
4.2		 4iv0A-1oi7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 TYR A 158
GLY A 125
GLY A 176
ILE A 127
ILE A 134
 None
 0.75A 4iv0B-1oi7A:
4.5		 4iv0B-1oi7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 7 VAL A 108
ILE A 111
LEU A   3
LEU A  91
 None
 0.93A 4l1wA-1oi7A:
1.2		 4l1wA-1oi7A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 TYR A 158
GLY A 125
GLY A 176
ILE A 127
ILE A 134
 None
 0.73A 4mwzA-1oi7A:
4.4		 4mwzA-1oi7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 TYR A 158
GLY A 125
GLY A 176
ILE A 127
ILE A 134
 None
 0.76A 4mwzB-1oi7A:
4.5		 4mwzB-1oi7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 7 VAL A 108
ILE A 111
LEU A   3
LEU A  91
 None
 0.86A 4xo7A-1oi7A:
undetectable		 4xo7A-1oi7A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 7 PHE A  71
ILE A  69
GLY A 135
THR A  24
 None
 1.06A 4zxiA-1oi7A:
5.6		 4zxiA-1oi7A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 ILE A 136
TYR A 158
ALA A 161
VAL A 141
GLY A 148
 None
 1.20A 5igiA-1oi7A:
undetectable		 5igiA-1oi7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 9 ALA A 107
ASP A 103
ILE A  99
GLY A 120
ILE A 119
 None
 1.03A 5kr0A-1oi7A:
undetectable		 5kr0A-1oi7A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 ALA A 107
ASP A 103
ILE A  99
GLY A 120
ILE A 119
 None
 1.06A 5kr1A-1oi7A:
undetectable		 5kr1A-1oi7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 ILE A 119
ARG A 117
LEU A 190
GLY A 178
GLY A 120
 None
 1.18A 5l6eA-1oi7A:
undetectable		 5l6eA-1oi7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 7 LEU A 118
GLY A 121
SER A 116
LEU A  82
ALA A 107
 None
 1.47A 5o96C-1oi7A:
2.3		 5o96C-1oi7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL A  38
TYR A  53
GLU A  83
 None
 0.91A 5zmqD-1oi7A:
undetectable
5zmqE-1oi7A:
undetectable		 5zmqD-1oi7A:
20.91
5zmqE-1oi7A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 GLY A 120
GLY A 121
ASN A 122
ILE A 119
GLY A 125
 None
 0.93A 6e5zA-1oi7A:
5.9		 6e5zA-1oi7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 GLY A 120
GLY A 121
ILE A 119
THR A 186
GLY A 176
 None
 1.01A 6e5zA-1oi7A:
5.9		 6e5zA-1oi7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL A  47
GLU A  46
ILE A  15
 None
 0.64A 6f7lB-1oi7A:
4.0		 6f7lB-1oi7A:
20.04