SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ois'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ois DNA TOPOISOMERASE I
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 177
GLY A 303
ALA A 185
GLY A 186
LEU A 191
 None
 1.18A 3ku1G-1oisA:
undetectable		 3ku1G-1oisA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 1ois DNA TOPOISOMERASE I
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 241
PHE A 187
ALA A 185
LEU A 162
 None
 0.97A 4ejgA-1oisA:
undetectable		 4ejgA-1oisA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ois DNA TOPOISOMERASE I
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 229
CYH A 232
LEU A 177
ILE A 224
LEU A 192
 None
 1.43A 5ycpA-1oisA:
undetectable		 5ycpA-1oisA:
15.18