SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1okc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		4 / 8 TYR A 131
PHE A 135
GLY A 175
VAL A  37
 None
 1.08A 1gsfA-1okcA:
0.4		 1gsfA-1okcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		4 / 8 TYR A 131
PHE A 135
GLY A 175
VAL A  37
 None
 1.08A 1gsfB-1okcA:
0.4		 1gsfB-1okcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		4 / 8 TYR A 131
PHE A 135
GLY A 175
VAL A  37
 None
 1.08A 1gsfD-1okcA:
0.5		 1gsfD-1okcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		5 / 9 PHE A 153
ARG A 137
ALA A 141
LEU A 140
ALA A 136
 None
None
None
CDL  A 800 (-3.8A)
None
 1.48A 2o01B-1okcA:
undetectable		 2o01B-1okcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		5 / 10 LEU A 127
SER A 126
ILE A 183
SER A 118
GLY A 119
 CXT  A 401 (-4.1A)
CXT  A 401 ( 4.9A)
CXT  A 401 (-4.8A)
None
None
 1.32A 3iluB-1okcA:
undetectable
3iluE-1okcA:
undetectable		 3iluB-1okcA:
23.49
3iluE-1okcA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		5 / 11 ILE A 183
SER A 118
GLY A 119
LEU A 127
SER A 126
 CXT  A 401 (-4.8A)
None
None
CXT  A 401 (-4.1A)
CXT  A 401 ( 4.9A)
 1.35A 3iluB-1okcA:
undetectable
3iluE-1okcA:
undetectable		 3iluB-1okcA:
23.49
3iluE-1okcA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		4 / 7 ASN A  76
ALA A  75
ARG A 139
ALA A 141
 None
 1.01A 3twpA-1okcA:
undetectable		 3twpA-1okcA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		4 / 7 ASN A  76
ALA A  75
ARG A 139
ALA A 141
 None
 1.12A 3twpB-1okcA:
undetectable		 3twpB-1okcA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		5 / 10 GLN A  84
ALA A  18
ALA A  19
THR A  23
LEU A  74
 CXT  A 401 ( 4.5A)
None
None
CDL  A 800 ( 4.1A)
CDL  A 800 ( 3.9A)
 1.18A 4j6cB-1okcA:
3.8		 4j6cB-1okcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		3 / 3 MET A 238
ASP A 231
PHE A 230
 None
CXT  A 401 (-3.6A)
LDM  A 904 ( 4.7A)
 1.06A 4xeyA-1okcA:
undetectable		 4xeyA-1okcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		3 / 3 MET A 238
ASP A 231
PHE A 230
 None
CXT  A 401 (-3.6A)
LDM  A 904 ( 4.7A)
 1.06A 4xeyB-1okcA:
undetectable		 4xeyB-1okcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		4 / 5 PHE A 129
THR A  83
ASP A 134
ASN A 177
 None
CXT  A 401 ( 3.9A)
CXT  A 401 ( 4.7A)
CDL  A 802 (-3.0A)
 1.00A 5ybbA-1okcA:
undetectable		 5ybbA-1okcA:
18.77