SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1olp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		3 / 3 VAL A 225
VAL A  13
TRP A   1
 None
 0.89A 1av2C-1olpA:
undetectable
1av2D-1olpA:
undetectable		 1av2C-1olpA:
10.22
1av2D-1olpA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		5 / 10 GLY A 226
ALA A 221
THR A 133
THR A  10
ALA A 155
 None
 1.29A 1gtnO-1olpA:
3.3
1gtnP-1olpA:
3.3		 1gtnO-1olpA:
11.35
1gtnP-1olpA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		5 / 9 GLY A 226
ALA A 221
THR A 133
THR A  10
ALA A 155
 None
 1.35A 1gtnQ-1olpA:
3.1
1gtnR-1olpA:
2.9		 1gtnQ-1olpA:
11.35
1gtnR-1olpA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 THR A  16
GLY A  51
PHE A  48
GLY A   7
 None
 0.78A 1jhaA-1olpA:
undetectable		 1jhaA-1olpA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 6 ASN A 132
HIS A  11
ALA A 228
GLY A 231
 None
ZN  A1373 (-3.1A)
None
None
 0.96A 1l5qA-1olpA:
undetectable		 1l5qA-1olpA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 6 ASN A 132
HIS A  11
ALA A 228
GLY A 231
 None
ZN  A1373 (-3.1A)
None
None
 0.94A 1l5qB-1olpA:
undetectable		 1l5qB-1olpA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		3 / 3 PHE A  48
LEU A 236
MET A  21
 None
 0.87A 1mx1D-1olpA:
undetectable		 1mx1D-1olpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		3 / 3 GLU A 152
HIS A 148
HIS A 136
 ZN  A1374 (-2.3A)
ZN  A1374 (-3.3A)
ZN  A1374 (-3.4A)
 0.70A 1oe2A-1olpA:
0.0		 1oe2A-1olpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		5 / 12 ARG A  99
PHE A 101
LEU A 121
ALA A 102
PHE A 185
 None
 1.23A 1og5A-1olpA:
undetectable		 1og5A-1olpA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		5 / 12 ARG A  99
PHE A 101
LEU A 121
ALA A 102
PHE A 185
 None
 1.18A 1og5B-1olpA:
1.7		 1og5B-1olpA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 SER A  96
ARG A  99
ASN A  93
ASP A  92
 None
 1.09A 1p6kA-1olpA:
0.0		 1p6kA-1olpA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 SER A  96
ARG A  99
ASN A  93
ASP A  92
 None
 1.07A 1p6kB-1olpA:
undetectable		 1p6kB-1olpA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 SER A  96
ARG A  99
ASN A  93
ASP A  92
 None
 1.05A 1rs7B-1olpA:
undetectable		 1rs7B-1olpA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 SER A  96
ARG A  99
ASN A  93
ASP A  92
 None
 1.15A 1zzqA-1olpA:
undetectable		 1zzqA-1olpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 SER A  96
ARG A  99
ASN A  93
ASP A  92
 None
 1.12A 1zzqB-1olpA:
undetectable		 1zzqB-1olpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 SER A  96
ARG A  99
ASN A  93
ASP A  92
 None
 1.19A 1zzuA-1olpA:
0.0		 1zzuA-1olpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 SER A  96
ARG A  99
ASN A  93
ASP A  92
 None
 1.04A 1zzuB-1olpA:
0.0		 1zzuB-1olpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		3 / 3 LYS A 283
ASP A 252
ASP A 349
 None
 1.17A 2br4A-1olpA:
undetectable		 2br4A-1olpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 7 THR A 272
PHE A 299
THR A 300
LYS A 263
 None
 1.27A 2kotA-1olpA:
0.9		 2kotA-1olpA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 7 ALA A  61
TYR A  62
ASP A  67
TYR A 127
 None
 1.29A 2pncA-1olpA:
undetectable		 2pncA-1olpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 6 ALA A  61
TYR A  62
ASP A  67
TYR A 127
 None
 1.31A 2pncB-1olpA:
0.0		 2pncB-1olpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 6 TYR A 192
LEU A 131
ASN A 132
LYS A 199
 None
 1.02A 2w98A-1olpA:
undetectable
2w98B-1olpA:
undetectable		 2w98A-1olpA:
21.59
2w98B-1olpA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 ASN A 186
SER A 189
TYR A 235
ASN A  93
 None
 1.16A 2wekA-1olpA:
undetectable		 2wekA-1olpA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 ASN A 186
SER A 189
TYR A 235
ASN A  93
 None
 1.18A 2wekB-1olpA:
undetectable		 2wekB-1olpA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		5 / 12 LEU A 309
ILE A 280
ILE A 258
PHE A 278
VAL A 343
 None
 0.99A 2ygoA-1olpA:
undetectable		 2ygoA-1olpA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 THR A 103
LYS A 111
ASP A  92
GLU A 354
 None
 0.99A 2zw9A-1olpA:
undetectable		 2zw9A-1olpA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 6 ASN A 132
HIS A  11
ALA A 228
GLY A 231
 None
ZN  A1373 (-3.1A)
None
None
 0.95A 3ddsA-1olpA:
undetectable		 3ddsA-1olpA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 6 ASN A 132
HIS A  11
ALA A 228
GLY A 231
 None
ZN  A1373 (-3.1A)
None
None
 0.93A 3ddsB-1olpA:
0.6		 3ddsB-1olpA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 6 ASN A 132
HIS A  11
ALA A 228
GLY A 231
 None
ZN  A1373 (-3.1A)
None
None
 0.96A 3ddwA-1olpA:
undetectable		 3ddwA-1olpA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 SER A  96
ARG A  99
ASN A  93
ASP A  92
 None
 1.09A 3n62B-1olpA:
0.0		 3n62B-1olpA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		3 / 3 TYR A 253
LEU A 309
LYS A 310
 None
 0.65A 3sueD-1olpA:
1.1		 3sueD-1olpA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		5 / 12 GLY A 124
GLY A  51
LEU A  38
VAL A 232
ALA A 233
 None
 1.17A 3t7vA-1olpA:
undetectable		 3t7vA-1olpA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		3 / 3 ARG A 163
GLU A  20
THR A  16
 None
 0.91A 3v4tA-1olpA:
0.0		 3v4tA-1olpA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 6 HIS A 136
TYR A  65
ALA A  94
TYR A 127
 ZN  A1374 (-3.4A)
None
None
None
 0.97A 4ae1A-1olpA:
undetectable		 4ae1A-1olpA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 7 ASN A 202
LYS A 199
LYS A 198
PHE A  78
 None
 1.18A 4yv5B-1olpA:
undetectable		 4yv5B-1olpA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 7 GLY A 224
SER A 222
LYS A 230
LEU A 164
 None
 0.87A 5izfA-1olpA:
undetectable		 5izfA-1olpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 8 ASP A 130
HIS A 126
PRO A  55
HIS A 136
 ZN  A1375 ( 2.5A)
ZN  A1375 (-3.3A)
None
ZN  A1374 (-3.4A)
 0.96A 5nekB-1olpA:
undetectable		 5nekB-1olpA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 6 GLU A  30
TYR A 237
GLY A 234
GLY A 231
 None
 0.98A 5x7pB-1olpA:
undetectable		 5x7pB-1olpA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 4 GLN A  17
VAL A 232
ARG A 158
ARG A 163
 None
 1.41A 6brdA-1olpA:
1.2		 6brdA-1olpA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		4 / 5 TYR A  62
GLN A  66
ASN A  77
THR A  79
 None
 1.41A 6d8pA-1olpA:
undetectable		 6d8pA-1olpA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1olp ALPHA-TOXIN
(Clostridium
sardiniense) 		3 / 3 LYS A   4
SER A  52
SER A  12
 None
 0.82A 6gbfA-1olpA:
0.0		 6gbfA-1olpA:
19.92