SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1olt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 TRP A 110
LEU A 118
ILE A 151
LEU A 159
LEU A 108
 None
 1.15A 1errB-1oltA:
undetectable		 1errB-1oltA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		3 / 3 ARG A 371
ILE A 388
TRP A 392
 None
 1.18A 1m8eB-1oltA:
0.0		 1m8eB-1oltA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 9 LEU A 343
ALA A  88
GLY A 325
LEU A 118
PHE A  61
 None
 1.05A 1nr6A-1oltA:
undetectable		 1nr6A-1oltA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 CYH A  69
THR A 114
ASP A 147
GLY A 170
ASP A 209
 SF4  A 500 ( 2.3A)
SAM  A 501 ( 3.5A)
SF4  A 500 (-4.2A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.7A)
 1.12A 1oltA-1oltA:
68.1		 1oltA-1oltA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		12 / 12 CYH A  71
THR A 114
GLU A 145
ASP A 147
GLY A 170
ARG A 184
ASP A 209
ILE A 211
PHE A 240
TYR A 242
ALA A 243
GLN A 252
 SAM  A 501 (-3.6A)
SAM  A 501 ( 3.5A)
SAM  A 502 ( 2.8A)
SF4  A 500 (-4.2A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 2.9A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.3A)
SAM  A 502 ( 3.6A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.9A)
SAM  A 501 (-4.6A)
 0.17A 1oltA-1oltA:
68.1		 1oltA-1oltA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 9 HIS A  58
GLY A 112
PHE A 240
PHE A 310
ILE A 329
 SAM  A 502 (-4.7A)
SAM  A 502 ( 4.1A)
SAM  A 502 ( 3.6A)
None
SAM  A 502 (-3.9A)
 1.19A 1oltA-1oltA:
68.1		 1oltA-1oltA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		9 / 9 TYR A  56
HIS A  58
GLY A 111
GLU A 145
PHE A 240
PHE A 310
GLN A 311
LEU A 321
ILE A 329
 SAM  A 502 (-3.5A)
SAM  A 502 (-4.7A)
SAM  A 502 (-3.6A)
SAM  A 502 ( 2.8A)
SAM  A 502 ( 3.6A)
None
SAM  A 502 (-3.0A)
None
SAM  A 502 (-3.9A)
 0.00A 1oltA-1oltA:
68.1		 1oltA-1oltA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLN A 172
HIS A  63
THR A 116
ILE A 151
 SAM  A 501 (-3.3A)
SAM  A 501 (-3.0A)
None
None
None
 1.42A 1z95A-1oltA:
0.0		 1z95A-1oltA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 7 SER A 168
SER A 143
GLN A 311
GLU A 145
 None
None
SAM  A 502 (-3.0A)
SAM  A 502 ( 2.8A)
 0.81A 2c8aA-1oltA:
undetectable		 2c8aA-1oltA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 8 LEU A 277
GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.36A 2eilP-1oltA:
undetectable
2eilW-1oltA:
undetectable		 2eilP-1oltA:
20.00
2eilW-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 6 GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.05A 3ablP-1oltA:
0.0
3ablW-1oltA:
undetectable		 3ablP-1oltA:
20.00
3ablW-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 8 LEU A 277
GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.32A 3asoC-1oltA:
undetectable
3asoJ-1oltA:
undetectable		 3asoC-1oltA:
20.00
3asoJ-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		3 / 3 ARG A 371
ILE A 388
TRP A 392
 None
 1.15A 3e68A-1oltA:
0.0		 3e68A-1oltA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		3 / 3 ARG A 371
ILE A 388
TRP A 392
 None
 1.21A 3e6tB-1oltA:
undetectable		 3e6tB-1oltA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 10 ILE A 423
GLY A 422
SER A 386
LEU A 377
SER A 376
 None
 1.25A 3ik6B-1oltA:
0.0
3ik6E-1oltA:
0.0		 3ik6B-1oltA:
21.36
3ik6E-1oltA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		3 / 3 ARG A  47
ASP A 320
ASP A 334
 None
 0.86A 3jb2A-1oltA:
undetectable		 3jb2A-1oltA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 PHE A  61
ALA A  82
LEU A  89
LEU A  86
GLY A 325
 None
 1.45A 3lbdA-1oltA:
undetectable		 3lbdA-1oltA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		3 / 3 ARG A 103
ASP A 334
GLN A 391
 None
 0.90A 3lcvB-1oltA:
undetectable		 3lcvB-1oltA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 ASP A 295
SER A 205
LEU A 297
THR A 315
GLN A 316
 None
 1.39A 3mbhB-1oltA:
undetectable		 3mbhB-1oltA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 ASP A 295
SER A 205
LEU A 297
THR A 315
GLN A 316
 None
 1.35A 3mbhC-1oltA:
4.3		 3mbhC-1oltA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 ASP A 295
SER A 205
LEU A 297
THR A 315
GLN A 316
 None
 1.37A 3mbhD-1oltA:
2.9		 3mbhD-1oltA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 ASP A 295
SER A 205
LEU A 297
THR A 315
GLN A 316
 None
 1.35A 3mbhE-1oltA:
4.3		 3mbhE-1oltA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 7 ILE A 208
LEU A 195
TYR A 282
ASN A 233
 None
 0.92A 3p50A-1oltA:
0.0		 3p50A-1oltA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 7 ILE A 208
LEU A 195
TYR A 282
ASN A 233
 None
 0.92A 3p50B-1oltA:
0.0		 3p50B-1oltA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 7 ILE A 208
LEU A 195
TYR A 282
ASN A 233
 None
 0.91A 3p50C-1oltA:
0.0		 3p50C-1oltA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 7 ILE A 208
LEU A 195
TYR A 282
ASN A 233
 None
 0.92A 3p50D-1oltA:
0.0		 3p50D-1oltA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 7 ILE A 208
LEU A 195
TYR A 282
ASN A 233
 None
 0.91A 3p50E-1oltA:
0.0		 3p50E-1oltA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 8 ASP A 320
GLY A 333
GLN A 107
ARG A 371
 None
 0.96A 3s3nA-1oltA:
undetectable		 3s3nA-1oltA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 ASN A 380
VAL A 425
ILE A 433
GLY A 286
ILE A 285
 None
 1.04A 3spkB-1oltA:
undetectable		 3spkB-1oltA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 6 GLN A   4
ILE A   6
PHE A 284
PHE A 290
 None
 0.98A 4fgkA-1oltA:
undetectable		 4fgkA-1oltA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 6 ILE A  74
TYR A 346
TYR A  85
PHE A  61
 None
 1.15A 4g10A-1oltA:
0.0		 4g10A-1oltA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 PHE A 284
GLN A   4
LEU A 277
TYR A 212
ILE A 269
 None
 1.10A 4g1bD-1oltA:
undetectable		 4g1bD-1oltA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		3 / 3 LEU A 214
PRO A 215
ARG A 149
 None
None
SF4  A 500 (-4.5A)
 0.44A 4klrB-1oltA:
undetectable		 4klrB-1oltA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 5 ARG A 365
THR A 364
ASP A 367
TYR A 443
 None
 1.44A 4oltA-1oltA:
0.0		 4oltA-1oltA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 5 ARG A 365
THR A 364
ASP A 367
TYR A 443
 None
 1.47A 4oltB-1oltA:
0.0		 4oltB-1oltA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 5 ARG A 365
THR A 364
ASP A 367
TYR A 443
 None
 1.44A 4qwpA-1oltA:
0.0		 4qwpA-1oltA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 8 ASN A 207
LEU A 195
LEU A 210
PHE A 290
 None
 0.86A 4r38D-1oltA:
undetectable		 4r38D-1oltA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 8 ASN A 207
LEU A 195
LEU A 210
PHE A 290
 None
 0.86A 4r3aA-1oltA:
undetectable		 4r3aA-1oltA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 10 THR A 206
ILE A 201
GLU A 200
ASN A 196
LEU A 232
 None
 1.47A 4r3aB-1oltA:
undetectable		 4r3aB-1oltA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 7 TYR A 336
PHE A  36
ALA A  44
LEU A 363
 None
 0.92A 4uymA-1oltA:
0.0		 4uymA-1oltA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		3 / 3 ASP A 209
ARG A 434
ARG A 308
 SAM  A 501 (-3.7A)
None
None
 0.98A 4x5iA-1oltA:
0.0		 4x5iA-1oltA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 6 ARG A 371
ARG A  47
ASP A 334
ASP A 320
 None
 1.29A 4xqeA-1oltA:
undetectable		 4xqeA-1oltA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 6 ARG A 371
ARG A  47
ASP A 334
ASP A 320
 None
 1.29A 4xqeB-1oltA:
undetectable		 4xqeB-1oltA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 7 LEU A 277
GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.38A 5b1aC-1oltA:
undetectable
5b1aJ-1oltA:
undetectable		 5b1aC-1oltA:
20.00
5b1aJ-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 7 LEU A 277
GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.37A 5b1aP-1oltA:
undetectable
5b1aW-1oltA:
undetectable		 5b1aP-1oltA:
20.00
5b1aW-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 6 GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.06A 5b1bC-1oltA:
undetectable
5b1bJ-1oltA:
undetectable		 5b1bC-1oltA:
20.00
5b1bJ-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		3 / 3 PHE A 164
ILE A 123
ASP A 154
 None
 0.55A 5cswA-1oltA:
undetectable		 5cswA-1oltA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		3 / 3 PHE A 164
ILE A 123
ASP A 154
 None
 0.65A 5cswB-1oltA:
undetectable		 5cswB-1oltA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 9 VAL A 416
VAL A 425
TYR A 385
PHE A 440
LEU A 407
 None
 1.34A 5e4dA-1oltA:
0.0		 5e4dA-1oltA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		3 / 3 ASP A 209
ARG A 434
ARG A 308
 SAM  A 501 (-3.7A)
None
None
 0.99A 5eajB-1oltA:
0.0		 5eajB-1oltA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 TYR A  23
TYR A 336
LEU A 363
ILE A 374
TYR A 313
 None
 1.22A 5ifuA-1oltA:
undetectable		 5ifuA-1oltA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 7 LEU A 277
GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.35A 5iy5C-1oltA:
undetectable
5iy5J-1oltA:
undetectable		 5iy5C-1oltA:
19.78
5iy5J-1oltA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 5 PHE A  68
ILE A 211
GLN A 179
ARG A 184
 SF4  A 500 ( 4.6A)
SAM  A 501 (-4.3A)
None
SAM  A 501 ( 2.9A)
 1.39A 5jm4A-1oltA:
undetectable		 5jm4A-1oltA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 4 PHE A  68
ILE A 211
GLN A 179
ARG A 184
 SF4  A 500 ( 4.6A)
SAM  A 501 (-4.3A)
None
SAM  A 501 ( 2.9A)
 1.47A 5jm4B-1oltA:
0.2		 5jm4B-1oltA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 7 LEU A 277
GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.34A 5z84C-1oltA:
undetectable
5z84J-1oltA:
undetectable		 5z84C-1oltA:
20.00
5z84J-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		3 / 3 ARG A 371
LYS A 375
ARG A 236
 None
 1.20A 6c06D-1oltA:
undetectable		 6c06D-1oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		5 / 12 ILE A 388
SER A 376
PHE A 396
LEU A 395
GLY A 422
 None
 1.11A 6dwnC-1oltA:
0.0		 6dwnC-1oltA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 8 TYR A 313
GLY A 317
ASN A 380
VAL A 305
 None
 1.01A 6giqL-1oltA:
0.0
6giqP-1oltA:
0.0
6giqT-1oltA:
0.0		 6giqL-1oltA:
24.07
6giqP-1oltA:
17.95
6giqT-1oltA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE
(Escherichia
coli) 		4 / 5 LEU A 277
GLN A   4
PHE A 284
PHE A 222
 None
 1.18A 6nmpP-1oltA:
0.0
6nmpW-1oltA:
0.0		 6nmpP-1oltA:
20.00
6nmpW-1oltA:
8.98