SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1olx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		3 / 3 TRP B 227
VAL B 163
TRP B 136
 None
 1.15A 1c4dA-1olxB:
undetectable
1c4dB-1olxB:
undetectable		 1c4dA-1olxB:
3.93
1c4dB-1olxB:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 11 ILE B 252
LEU B 224
GLY B 219
SER B 220
GLU B 250
 None
 1.37A 1kyvA-1olxB:
2.4
1kyvB-1olxB:
7.1		 1kyvA-1olxB:
20.00
1kyvB-1olxB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 11 ILE B 326
HIS B 141
GLY B 137
GLU B 280
LEU B 193
 None
 1.49A 1kyvA-1olxB:
2.4
1kyvB-1olxB:
7.1		 1kyvA-1olxB:
20.00
1kyvB-1olxB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 11 GLY B 137
GLU B 280
LEU B 193
ILE B 326
HIS B 141
 None
 1.42A 2a58A-1olxB:
5.0
2a58E-1olxB:
5.7		 2a58A-1olxB:
18.44
2a58E-1olxB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 11 ILE B 326
HIS B 141
GLY B 137
GLU B 280
LEU B 193
 None
 1.43A 2a58C-1olxB:
5.7
2a58D-1olxB:
5.7		 2a58C-1olxB:
18.44
2a58D-1olxB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		4 / 6 LEU B 275
LEU B 276
ILE B 291
ARG B 309
 None
 1.01A 2rlfA-1olxB:
0.0
2rlfB-1olxB:
0.0		 2rlfA-1olxB:
11.42
2rlfB-1olxB:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE B  82
GLY B  81
GLU B 113
ALA B  95
 None
 0.85A 3aodA-1olxB:
undetectable		 3aodA-1olxB:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 9 ALA B 226
ASP B 253
ILE B 326
VAL B 237
ILE B 234
 None
 1.03A 3ekvB-1olxB:
undetectable		 3ekvB-1olxB:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 9 ALA B 226
ASP B 253
ILE B 326
VAL B 237
ILE B 234
 None
 0.92A 3nu4A-1olxB:
undetectable		 3nu4A-1olxB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 10 ALA B 226
ASP B 253
ILE B 326
VAL B 237
ILE B 234
 None
 0.93A 3nu6A-1olxB:
undetectable		 3nu6A-1olxB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 10 ALA B 226
ASP B 253
ILE B 326
VAL B 237
ILE B 234
 None
 0.91A 3nujA-1olxB:
undetectable		 3nujA-1olxB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 9 ALA B 226
ASP B 253
ILE B 326
VAL B 237
ILE B 234
 None
 0.92A 3nuoA-1olxB:
undetectable		 3nuoA-1olxB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		4 / 8 ALA B  30
VAL B  27
LEU B  23
LEU B 174
 None
 0.83A 3roxA-1olxB:
undetectable		 3roxA-1olxB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 10 ALA B 226
ASP B 253
ILE B 326
VAL B 237
ILE B 234
 None
 1.02A 4q1wB-1olxB:
undetectable		 4q1wB-1olxB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		4 / 8 ILE B 257
LEU B 276
VAL B 295
ILE B 307
 None
 0.75A 4r38A-1olxB:
undetectable		 4r38A-1olxB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		4 / 8 ILE B 257
LEU B 276
VAL B 295
ILE B 307
 None
 0.78A 4r38D-1olxB:
undetectable		 4r38D-1olxB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		3 / 3 GLU B 322
THR B 229
HIS B   3
 None
 0.82A 4ydqB-1olxB:
3.9		 4ydqB-1olxB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		3 / 3 ARG B 133
TYR B 194
GLU B 189
 None
 0.66A 4zzbE-1olxB:
undetectable		 4zzbE-1olxB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZD_A_RBFA201_1
(TRANSCRIPTIONAL
REGULATOR, PADR-LIKE
FAMILY)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		4 / 4 ALA B 155
VAL B 162
TRP B 227
ASP B 253
 None
 1.29A 4zzdA-1olxB:
0.0		 4zzdA-1olxB:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 8 VAL B 162
VAL B 231
ILE B 234
ILE B 277
PHE B 287
 None
 1.47A 5hi2A-1olxB:
undetectable		 5hi2A-1olxB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 8 GLY B  90
ALA B  91
VAL B  42
GLY B  83
ILE B  84
 None
 1.38A 5kr1B-1olxB:
undetectable		 5kr1B-1olxB:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		3 / 3 PHE B 324
ASP B 328
LEU B 283
 None
 0.79A 5uhbC-1olxB:
undetectable		 5uhbC-1olxB:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 12 THR B  57
LEU B  60
ILE B 179
GLU B  96
THR B 131
 None
None
None
None
K  B 502 (-4.4A)
 1.49A 5w8aA-1olxB:
0.2		 5w8aA-1olxB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		3 / 3 ARG B 309
ILE B 277
SER B 292
 None
 0.88A 5zw2A-1olxB:
undetectable		 5zw2A-1olxB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens) 		5 / 11 ALA B  87
LEU B 130
THR B 131
ILE B  43
THR B  72
 None
None
K  B 502 (-4.4A)
None
None
 1.19A 6h1lB-1olxB:
undetectable		 6h1lB-1olxB:
23.06