SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1omx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		3 / 3 LYS A 182
ILE A 297
THR A 254
 None
 0.86A 1rx3A-1omxA:
undetectable		 1rx3A-1omxA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		5 / 10 ILE A 316
ILE A 314
GLY A 262
ILE A 175
ALA A 164
 None
EDO  A 401 (-4.7A)
None
None
None
 0.93A 1sh9B-1omxA:
undetectable		 1sh9B-1omxA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		5 / 9 TYR A 209
PHE A 264
VAL A 212
GLY A 262
GLY A 177
 None
 1.07A 3csjB-1omxA:
undetectable		 3csjB-1omxA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		4 / 8 TYR A 209
VAL A 212
GLY A 262
GLY A 177
 None
 0.72A 3n9jB-1omxA:
undetectable		 3n9jB-1omxA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		3 / 3 LYS A 182
ILE A 297
THR A 254
 None
 0.87A 4gh8A-1omxA:
undetectable		 4gh8A-1omxA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		4 / 8 MET A 249
ALA A 248
VAL A  99
PHE A 139
 None
 0.94A 4ltwA-1omxA:
undetectable		 4ltwA-1omxA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		4 / 7 ASN A 220
PHE A 219
TRP A 168
PHE A 165
 EDO  A 403 ( 3.8A)
None
None
None
 1.17A 4v32B-1omxA:
undetectable		 4v32B-1omxA:
17.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		3 / 3 LEU A 148
PHE A 219
ILE A  70
 None
 0.73A 5dzk1-1omxA:
undetectable
5dzkF-1omxA:
undetectable
5dzkM-1omxA:
undetectable		 5dzk1-1omxA:
50.00
5dzkF-1omxA:
19.73
5dzkM-1omxA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		3 / 3 ILE A 263
MET A 249
ASP A 173
 EDO  A 401 ( 4.8A)
None
None
 0.72A 5h2uA-1omxA:
undetectable		 5h2uA-1omxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		4 / 8 ILE A 190
GLY A 189
PHE A 290
ASN A 302
 None
 0.79A 5hieD-1omxA:
undetectable		 5hieD-1omxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		4 / 5 MET A 307
TYR A 209
TYR A 311
GLY A 262
 None
 1.11A 5x7pA-1omxA:
0.0		 5x7pA-1omxA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2
(Mus
musculus) 		4 / 4 PRO A 308
LEU A 309
VAL A 253
ARG A 255
 None
 1.20A 6fgdA-1omxA:
0.0		 6fgdA-1omxA:
21.61