SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1on9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 12 ILE A 300
ILE A 297
ALA A 333
ARG A 497
THR A 496
 None
 1.03A 1kijB-1on9A:
undetectable		 1kijB-1on9A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 10 ASP A 150
GLU A 147
GLY A 154
ILE A 145
ALA A 143
 None
 1.01A 1x7pA-1on9A:
undetectable
1x7pB-1on9A:
undetectable		 1x7pA-1on9A:
20.89
1x7pB-1on9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 4 THR A 513
THR A 400
ASP A 427
ASP A 488
 None
 1.40A 2f8lA-1on9A:
undetectable		 2f8lA-1on9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		3 / 3 ILE A 331
ILE A 500
LEU A 343
 None
 0.54A 2prgA-1on9A:
undetectable		 2prgA-1on9A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 8 PHE A 266
PRO A 402
ALA A 508
LEU A 504
 None
 0.88A 2vcvF-1on9A:
undetectable		 2vcvF-1on9A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 7 PRO A 376
ILE A 385
PRO A 372
GLY A 373
 None
 0.92A 2y7kA-1on9A:
0.0		 2y7kA-1on9A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 11 LEU A  20
VAL A  17
GLY A  15
GLU A  18
ALA A  21
 None
 1.02A 2yy8A-1on9A:
undetectable
2yy8B-1on9A:
3.7		 2yy8A-1on9A:
18.64
2yy8B-1on9A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 10 GLY A 425
ALA A 426
ASP A 427
VAL A 355
VAL A 369
 None
 0.94A 3oxwA-1on9A:
undetectable		 3oxwA-1on9A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 10 GLY A 425
ALA A 426
ASP A 427
VAL A 355
VAL A 369
 None
 0.82A 3oxwC-1on9A:
undetectable		 3oxwC-1on9A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		3 / 3 PHE A 105
LYS A  38
SER A  41
 MCA  A4001 (-4.4A)
None
None
 1.36A 3tyeB-1on9A:
undetectable		 3tyeB-1on9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 12 CYH A 179
ALA A 183
ASN A 162
ALA A 173
ILE A 193
 None
 1.17A 3ut5B-1on9A:
2.8		 3ut5B-1on9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 8 ASP A 302
VAL A 301
GLY A 330
VAL A 296
ILE A 300
 None
 1.48A 4ll3A-1on9A:
undetectable		 4ll3A-1on9A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 7 ILE A 297
ARG A 294
ILE A 331
ALA A 320
 None
 0.81A 4lv9A-1on9A:
undetectable		 4lv9A-1on9A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 7 ILE A 297
ARG A 294
ILE A 331
ALA A 320
 None
 0.81A 4lv9B-1on9A:
2.5		 4lv9B-1on9A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 6 ASP A 359
ASN A 356
ALA A 395
TYR A 396
 None
 1.15A 4mdbA-1on9A:
0.6		 4mdbA-1on9A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		3 / 3 ALA A 161
GLN A 116
GLY A  85
 None
 0.42A 4odoC-1on9A:
undetectable		 4odoC-1on9A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 4 SER A 102
GLU A  49
GLU A  37
ASP A 139
 None
 1.49A 4pclB-1on9A:
0.6		 4pclB-1on9A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 10 ASP A 370
ASP A 292
VAL A 296
ILE A 285
PRO A 493
 None
 1.03A 4q1wB-1on9A:
undetectable		 4q1wB-1on9A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 8 ILE A 331
THR A 315
VAL A 338
SER A 337
 None
 0.75A 4r20A-1on9A:
undetectable		 4r20A-1on9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 7 THR A  71
GLU A 147
ARG A  67
GLY A 113
 None
 0.81A 4rdxA-1on9A:
undetectable		 4rdxA-1on9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 12 SER A 117
GLY A 154
PHE A 159
ALA A 112
GLN A 103
 None
 1.12A 4ubeA-1on9A:
undetectable		 4ubeA-1on9A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 12 VAL A 318
TYR A 313
ILE A 194
ILE A 193
ASN A 234
 None
 1.15A 4xueA-1on9A:
undetectable		 4xueA-1on9A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 5 ILE A 404
GLY A 330
ILE A 500
LEU A 365
 None
 0.89A 5dzki-1on9A:
11.8
5dzkj-1on9A:
11.8
5dzkx-1on9A:
undetectable		 5dzki-1on9A:
17.42
5dzkj-1on9A:
17.42
5dzkx-1on9A:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 4 ILE A 404
GLY A 330
ILE A 500
LEU A 365
 None
 0.90A 5dzkl-1on9A:
11.8
5dzkz-1on9A:
undetectable		 5dzkl-1on9A:
17.42
5dzkz-1on9A:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 7 GLU A 147
GLY A  85
SER A 111
GLY A 109
 None
None
MCA  A4001 (-3.7A)
MCA  A4001 (-3.0A)
 0.80A 5e26A-1on9A:
undetectable
5e26B-1on9A:
undetectable		 5e26A-1on9A:
22.46
5e26B-1on9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 7 GLU A 147
GLY A  85
SER A 111
GLY A 109
 None
None
MCA  A4001 (-3.7A)
MCA  A4001 (-3.0A)
 0.81A 5e26C-1on9A:
undetectable
5e26D-1on9A:
undetectable		 5e26C-1on9A:
22.46
5e26D-1on9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		3 / 3 PRO A 372
LEU A 317
SER A 340
 None
 0.58A 5fsaB-1on9A:
undetectable		 5fsaB-1on9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		3 / 3 GLY A 142
GLY A 141
GLN A 103
 MCA  A4001 ( 4.1A)
MCA  A4001 (-3.4A)
None
 0.47A 5imsA-1on9A:
2.1		 5imsA-1on9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 5 GLU A 147
GLY A  85
SER A 111
GLY A 109
 None
None
MCA  A4001 (-3.7A)
MCA  A4001 (-3.0A)
 0.89A 5kprA-1on9A:
undetectable		 5kprA-1on9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 10 VAL A 267
ALA A 264
SER A 328
THR A 132
LEU A 253
 None
 1.24A 5mm4B-1on9A:
undetectable		 5mm4B-1on9A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 12 TYR A 291
GLY A 341
GLY A 290
ASN A 316
ASP A 370
 None
 1.27A 5yn6A-1on9A:
undetectable		 5yn6A-1on9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		3 / 3 GLY A 141
ASP A 139
ILE A 175
 MCA  A4001 (-3.4A)
None
None
 0.57A 6dgxB-1on9A:
undetectable		 6dgxB-1on9A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 8 ARG A  50
VAL A 309
ARG A  96
GLN A 258
 None
 1.21A 6fbvD-1on9A:
undetectable		 6fbvD-1on9A:
17.79