SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1onf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 LYS A 173
LEU A  76
PHE A  74
LEU A 197
 None
 0.97A 2eilP-1onfA:
undetectable
2eilW-1onfA:
undetectable		 2eilP-1onfA:
17.91
2eilW-1onfA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 TYR A 307
LEU A 145
LEU A 363
ALA A  20
 None
 1.04A 2wekA-1onfA:
2.9		 2wekA-1onfA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 ALA A  16
ALA A  17
VAL A 295
ILE A 293
CYH A 312
 None
 0.96A 3e00A-1onfA:
undetectable		 3e00A-1onfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		5 / 10 ALA A  16
ALA A  17
VAL A 295
ILE A 293
CYH A 312
 None
 0.83A 3falA-1onfA:
undetectable		 3falA-1onfA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		5 / 10 ASP A   3
ASN A 143
TYR A 106
ASP A 104
GLY A 141
 None
 1.41A 3myuB-1onfA:
0.0		 3myuB-1onfA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		4 / 7 SER A  33
GLY A  37
THR A  38
THR A 109
 FAD  A 500 ( 4.0A)
FAD  A 500 ( 3.7A)
FAD  A 500 (-3.6A)
FAD  A 500 (-4.2A)
 1.04A 4ac9C-1onfA:
undetectable		 4ac9C-1onfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 ASN A 229
ALA A  54
ASN A 192
GLY A 454
ASP A 225
 None
 1.15A 4qckA-1onfA:
0.0		 4qckA-1onfA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		5 / 8 ALA A 147
VAL A   6
GLY A  12
ALA A 356
GLY A 360
 None
None
FAD  A 500 (-3.7A)
FAD  A 500 ( 4.1A)
None
 1.23A 4zjzB-1onfA:
2.1		 4zjzB-1onfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		4 / 7 LYS A 173
LEU A  76
PHE A  74
LEU A 197
 None
 0.99A 5b3sP-1onfA:
undetectable		 5b3sP-1onfA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		5 / 8 ILE A  59
ILE A 191
ILE A 210
ILE A 231
ASP A 225
 None
 1.47A 5hi2A-1onfA:
undetectable		 5hi2A-1onfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 VAL A 461
PHE A 464
PHE A 491
ILE A 411
VAL A 439
 None
 1.11A 5n0sA-1onfA:
undetectable		 5n0sA-1onfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 ARG A 196
ILE A 172
PHE A 170
ILE A 186
ALA A 187
 None
None
None
FAD  A 500 ( 4.3A)
None
 1.19A 5vc0A-1onfA:
0.0		 5vc0A-1onfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		4 / 6 LYS A 173
LEU A  76
PHE A  74
LEU A 197
 None
 1.03A 5x19P-1onfA:
undetectable		 5x19P-1onfA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 1onf GLUTATHIONE
REDUCTASE
(Plasmodium
falciparum) 		5 / 11 GLY A   8
GLU A  31
LYS A  32
SER A  33
ALA A 110
 FAD  A 500 (-2.8A)
FAD  A 500 (-2.6A)
FAD  A 500 (-3.3A)
FAD  A 500 ( 4.0A)
FAD  A 500 (-3.3A)
 0.74A 5x6yC-1onfA:
undetectable		 5x6yC-1onfA:
21.41