SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ons'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		5 / 10 GLU A  92
ALA A  94
LEU A 132
LEU A 139
GLU A 144
 None
 1.31A 1a29A-1onsA:
undetectable		 1a29A-1onsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		5 / 8 HIS A 185
GLY A  71
MET A 222
LEU A 226
ASP A 213
 None
 1.49A 1aegA-1onsA:
undetectable		 1aegA-1onsA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		5 / 12 ALA A 146
ILE A 205
THR A 258
LEU A 183
LEU A  84
 None
 1.32A 1eiiA-1onsA:
0.0		 1eiiA-1onsA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		3 / 3 ILE A  96
LEU A 132
VAL A 136
 None
 0.46A 1mz9B-1onsA:
undetectable		 1mz9B-1onsA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		5 / 12 PRO A 209
PHE A 208
SER A 182
VAL A 150
ALA A 264
 None
 0.98A 1nw5A-1onsA:
undetectable		 1nw5A-1onsA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		4 / 7 ALA A 156
PHE A  68
ASN A  72
GLU A  76
 None
 1.21A 1t9wA-1onsA:
undetectable		 1t9wA-1onsA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		5 / 12 ALA A 188
GLY A 152
GLY A 153
LEU A 157
LEU A 160
 None
 0.96A 1ya4A-1onsA:
undetectable		 1ya4A-1onsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		3 / 3 LEU A  81
PRO A  80
LEU A  84
 None
 0.53A 2po5B-1onsA:
undetectable		 2po5B-1onsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		3 / 3 LEU A  81
PRO A  80
LEU A  84
 None
 0.56A 2po7B-1onsA:
2.3		 2po7B-1onsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		4 / 6 LEU A  25
SER A 261
PHE A 263
ASP A 260
 None
 1.33A 2vn1B-1onsA:
undetectable		 2vn1B-1onsA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		4 / 8 LEU A 226
PRO A 161
GLY A 186
PRO A 187
 None
 0.78A 3hcrA-1onsA:
2.4		 3hcrA-1onsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		5 / 12 PRO A 151
GLY A 152
GLY A 153
VAL A 180
LEU A 193
 None
 1.04A 3m6vA-1onsA:
undetectable		 3m6vA-1onsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		5 / 12 PRO A 151
GLY A 152
GLY A 153
VAL A 180
LEU A 193
 None
 1.02A 3m6vB-1onsA:
3.0		 3m6vB-1onsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		5 / 12 PRO A 151
GLY A 152
GLY A 153
VAL A 180
LEU A 193
 None
 1.04A 3m6wA-1onsA:
undetectable		 3m6wA-1onsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		5 / 10 TYR A 221
LEU A  60
PRO A 217
LEU A 226
GLY A 152
 None
 1.32A 4zp0A-1onsA:
0.0		 4zp0A-1onsA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		4 / 8 TRP A 228
THR A 227
TYR A 229
LEU A 157
 None
 1.00A 5kxiD-1onsA:
undetectable
5kxiE-1onsA:
undetectable		 5kxiD-1onsA:
20.05
5kxiE-1onsA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		4 / 6 ASN A  16
ALA A  17
PRO A 223
ASP A  15
 None
 1.12A 5umd2-1onsA:
undetectable
5umdF-1onsA:
undetectable		 5umd2-1onsA:
12.77
5umdF-1onsA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		4 / 8 VAL A 135
ASP A 134
PRO A 129
GLY A  98
 None
 0.90A 5w3jB-1onsA:
undetectable		 5w3jB-1onsA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		4 / 7 PHE A 230
ARG A 194
LEU A 234
ALA A 207
 None
 1.04A 6b89A-1onsA:
0.0		 6b89A-1onsA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1ons CHAPERONE PROTEIN
HCHA
(Escherichia
coli) 		4 / 8 TRP A 228
THR A 227
TYR A 229
LEU A 157
 None
 0.83A 6cnjD-1onsA:
undetectable
6cnjE-1onsA:
undetectable		 6cnjD-1onsA:
15.64
6cnjE-1onsA:
15.50