SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ooe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		5 / 9 LEU A  31
VAL A  76
GLY A  75
ALA A 115
LEU A 114
 None
 1.15A 1e7bA-1ooeA:
undetectable		 1e7bA-1ooeA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		5 / 12 LEU A 125
VAL A  76
GLY A  75
LEU A 164
ALA A 115
 None
 1.01A 2egvA-1ooeA:
2.1		 2egvA-1ooeA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		5 / 12 LEU A 125
VAL A  76
GLY A  75
LEU A 164
ALA A 115
 None
 1.08A 2egvB-1ooeA:
2.1		 2egvB-1ooeA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		5 / 9 ALA A 112
LEU A 164
LEU A 119
VAL A  76
SER A 218
 None
 1.29A 3freX-1ooeA:
undetectable		 3freX-1ooeA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		4 / 8 LEU A 171
THR A 172
ALA A 112
THR A 116
 None
 0.61A 3jusA-1ooeA:
undetectable		 3jusA-1ooeA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		4 / 8 LEU A 171
THR A 172
ALA A 112
THR A 116
 None
 0.61A 3jusA-1ooeA:
undetectable		 3jusA-1ooeA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		4 / 7 ASN A  38
ALA A  41
ASP A  42
VAL A   8
 None
 0.98A 4eyrA-1ooeA:
undetectable		 4eyrA-1ooeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		6 / 9 LEU A 125
ALA A 111
ALA A 109
LEU A 153
LEU A 164
ALA A 115
 None
 1.26A 4z91F-1ooeA:
0.0
4z91G-1ooeA:
0.0
4z91H-1ooeA:
0.0
4z91I-1ooeA:
0.0
4z91J-1ooeA:
0.0		 4z91F-1ooeA:
20.06
4z91G-1ooeA:
20.06
4z91H-1ooeA:
20.06
4z91I-1ooeA:
20.06
4z91J-1ooeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		6 / 9 LEU A 125
ALA A 111
LEU A 127
LEU A 153
LEU A 164
ALA A 115
 None
 1.24A 4z91F-1ooeA:
0.0
4z91G-1ooeA:
0.0
4z91H-1ooeA:
0.0
4z91I-1ooeA:
0.0
4z91J-1ooeA:
0.0		 4z91F-1ooeA:
20.06
4z91G-1ooeA:
20.06
4z91H-1ooeA:
20.06
4z91I-1ooeA:
20.06
4z91J-1ooeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		6 / 9 LEU A 127
ALA A 109
LEU A 153
LEU A 164
LEU A 125
ALA A 111
 None
 1.26A 4z91F-1ooeA:
0.0
4z91G-1ooeA:
0.0
4z91H-1ooeA:
0.0
4z91I-1ooeA:
0.0
4z91J-1ooeA:
0.0		 4z91F-1ooeA:
20.06
4z91G-1ooeA:
20.06
4z91H-1ooeA:
20.06
4z91I-1ooeA:
20.06
4z91J-1ooeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		6 / 9 LEU A 164
ALA A 115
LEU A 125
ALA A 111
ALA A 109
LEU A 153
 None
 1.19A 4z91F-1ooeA:
0.0
4z91G-1ooeA:
0.0
4z91H-1ooeA:
0.0
4z91I-1ooeA:
0.0
4z91J-1ooeA:
0.0		 4z91F-1ooeA:
20.06
4z91G-1ooeA:
20.06
4z91H-1ooeA:
20.06
4z91I-1ooeA:
20.06
4z91J-1ooeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		6 / 9 LEU A 164
ALA A 115
LEU A 125
ALA A 111
LEU A 127
LEU A 153
 None
 1.14A 4z91F-1ooeA:
0.0
4z91G-1ooeA:
0.0
4z91H-1ooeA:
0.0
4z91I-1ooeA:
0.0
4z91J-1ooeA:
0.0		 4z91F-1ooeA:
20.06
4z91G-1ooeA:
20.06
4z91H-1ooeA:
20.06
4z91I-1ooeA:
20.06
4z91J-1ooeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		6 / 9 LEU A 164
ALA A 115
LEU A 125
ALA A 111
LEU A 127
LEU A 153
 None
 1.18A 4z91F-1ooeA:
0.0
4z91G-1ooeA:
0.0
4z91H-1ooeA:
0.0
4z91I-1ooeA:
0.0
4z91J-1ooeA:
0.0		 4z91F-1ooeA:
20.06
4z91G-1ooeA:
20.06
4z91H-1ooeA:
20.06
4z91I-1ooeA:
20.06
4z91J-1ooeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		4 / 6 ILE A 201
PHE A 200
PHE A  23
THR A 210
 None
 1.16A 5g08A-1ooeA:
undetectable		 5g08A-1ooeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1ooe DIHYDROPTERIDINE
REDUCTASE
(Caenorhabditis
elegans) 		5 / 12 ALA A 149
GLY A 142
GLY A 144
SER A  87
PHE A  93
 None
 1.21A 6clxA-1ooeA:
4.8		 6clxA-1ooeA:
21.47