SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ope'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		4 / 6 ASN A  51
PHE A  25
GLY A 385
TYR A  76
 None
 1.13A 1c8lA-1opeA:
undetectable		 1c8lA-1opeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		4 / 7 VAL A 400
LEU A 360
THR A 358
LEU A 357
 None
 0.69A 1jgsA-1opeA:
0.0		 1jgsA-1opeA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		4 / 6 ASN A  51
PHE A  25
GLY A 385
TYR A  76
 None
 1.12A 1l5qA-1opeA:
undetectable		 1l5qA-1opeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		4 / 5 GLY A  90
PRO A 132
ALA A 144
ILE A 143
 None
 0.92A 2aofA-1opeA:
undetectable		 2aofA-1opeA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		4 / 7 SER A 304
SER A 346
GLN A  99
GLU A 305
 None
 1.30A 2c8aA-1opeA:
undetectable		 2c8aA-1opeA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		5 / 12 PHE A 184
ALA A 188
SER A 187
ALA A 173
GLY A  29
 None
 1.30A 2igtC-1opeA:
2.9		 2igtC-1opeA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		4 / 5 ASN A  51
PHE A  25
GLY A 385
TYR A  76
 None
 1.11A 3bcrA-1opeA:
undetectable		 3bcrA-1opeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		4 / 6 SER A 295
LEU A 282
ALA A 271
LEU A 272
 None
 0.67A 3kk6B-1opeA:
undetectable		 3kk6B-1opeA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		5 / 11 VAL A  94
LEU A  92
MET A 375
VAL A 381
GLY A 383
 None
 1.26A 3pghB-1opeA:
undetectable		 3pghB-1opeA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		5 / 10 PRO A 194
ASN A  51
GLY A  23
GLY A 100
ALA A 103
 None
 1.36A 3pp7B-1opeA:
undetectable		 3pp7B-1opeA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		5 / 12 THR A 422
GLY A 121
GLY A 123
ASP A 389
SER A 392
 None
 1.40A 3tkaA-1opeA:
undetectable		 3tkaA-1opeA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		4 / 8 ASN A 326
PRO A 313
TYR A 340
LEU A 324
 None
 0.97A 4jjkA-1opeA:
undetectable		 4jjkA-1opeA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		5 / 12 LEU A  46
ALA A  48
LEU A 170
ILE A  30
GLY A  24
 None
 1.13A 5gtrA-1opeA:
undetectable		 5gtrA-1opeA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		4 / 8 GLU A 205
VAL A 203
GLY A  36
LEU A  38
 None
 1.00A 5sxqA-1opeA:
undetectable		 5sxqA-1opeA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		5 / 12 GLY A  54
GLY A  26
ILE A  69
GLY A  59
GLY A  61
 None
 1.11A 5wyqA-1opeA:
undetectable		 5wyqA-1opeA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		5 / 10 ARG A 242
GLY A  24
PHE A  25
ASN A 190
ALA A  48
 None
 1.35A 5x66D-1opeA:
undetectable		 5x66D-1opeA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		4 / 7 SER A  66
ALA A  37
VAL A 203
LEU A 170
 None
 0.71A 6dwnB-1opeA:
undetectable		 6dwnB-1opeA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		5 / 12 PRO A  15
LEU A  46
VAL A  22
PRO A  31
LEU A  38
 None
 1.30A 6eliA-1opeA:
0.0		 6eliA-1opeA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Sus
scrofa) 		4 / 6 GLY A  23
ARG A 189
SER A 342
SER A 343
 None
 1.05A 6jogA-1opeA:
undetectable		 6jogA-1opeA:
15.83