SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1opg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1opg OPG2 FAB (HEAVY
CHAIN)
(Homo
sapiens) 		5 / 12 PHE H 158
THR H  91
PRO H  14
ASN H  13
LEU H  11
 None
 1.11A 1dhfA-1opgH:
undetectable		 1dhfA-1opgH:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 1opg OPG2 FAB (HEAVY
CHAIN)
(Homo
sapiens) 		3 / 3 ARG H 200
ARG H 225
PRO H 138
 None
 1.08A 2wljA-1opgH:
3.4		 2wljA-1opgH:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 1opg OPG2 FAB (HEAVY
CHAIN)
(Homo
sapiens) 		5 / 11 GLN H 117
MET H  34
GLY H 116
GLY H  26
ASN H  77
 None
 1.36A 3v3nA-1opgH:
undetectable		 3v3nA-1opgH:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 1opg OPG2 FAB (HEAVY
CHAIN)
(Homo
sapiens) 		5 / 11 GLN H 117
MET H  34
GLY H 116
GLY H  26
ASN H  77
 None
 1.37A 3v3nD-1opgH:
undetectable		 3v3nD-1opgH:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 1opg OPG2 FAB (HEAVY
CHAIN)
(Homo
sapiens) 		5 / 11 GLN H 117
MET H  34
GLY H 116
GLY H  26
ASN H  77
 None
 1.37A 4a99D-1opgH:
undetectable		 4a99D-1opgH:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1opg OPG2 FAB (HEAVY
CHAIN)
(Homo
sapiens) 		4 / 5 TYR H 102
TYR H  32
GLY H  53
GLY H  54
 None
 0.71A 5x7pA-1opgH:
1.1		 5x7pA-1opgH:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1opg OPG2 FAB (HEAVY
CHAIN)
(Homo
sapiens) 		4 / 6 TYR H 102
TYR H  32
GLY H  53
GLY H  54
 None
 0.77A 5x7pB-1opgH:
undetectable		 5x7pB-1opgH:
11.08