SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1or4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 7 ILE A  65
TYR A 148
THR A 166
LEU A 169
 None
 1.01A 1v54N-1or4A:
0.0
1v54W-1or4A:
undetectable		 1v54N-1or4A:
14.76
1v54W-1or4A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 7 ILE A  65
TYR A 148
THR A 166
LEU A 169
 None
 1.02A 2dyrN-1or4A:
0.1
2dyrW-1or4A:
0.0		 2dyrN-1or4A:
14.76
2dyrW-1or4A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 6 ILE A  65
TYR A 148
THR A 166
LEU A 169
 None
 1.00A 2einN-1or4A:
0.0
2einW-1or4A:
undetectable		 2einN-1or4A:
14.76
2einW-1or4A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 6 ILE A  65
TYR A 148
THR A 166
LEU A 169
 None
 1.03A 3ag1N-1or4A:
0.0
3ag1W-1or4A:
undetectable		 3ag1N-1or4A:
14.76
3ag1W-1or4A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 8 ARG A  24
LEU A  54
ILE A  58
PHE A 104
 None
 0.93A 3ln1A-1or4A:
undetectable		 3ln1A-1or4A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 7 ARG A  24
LEU A  54
ILE A  58
PHE A 104
 None
 0.93A 3ln1B-1or4A:
undetectable		 3ln1B-1or4A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 6 ILE A  65
TYR A 148
THR A 166
LEU A 169
 None
 1.04A 3wg7N-1or4A:
0.0
3wg7W-1or4A:
0.0		 3wg7N-1or4A:
14.76
3wg7W-1or4A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		5 / 12 LEU A  96
LEU A  73
ILE A 126
ILE A  82
HIS A  86
 CYN  A 181 ( 4.5A)
HEM  A 180 ( 4.7A)
HEM  A 180 (-4.5A)
HEM  A 180 (-3.5A)
HEM  A 180 (-4.7A)
 1.29A 4j26B-1or4A:
1.0		 4j26B-1or4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		5 / 12 GLN A  53
ALA A 161
LEU A  57
GLU A 157
PHE A  14
 None
 1.10A 4pb1A-1or4A:
undetectable		 4pb1A-1or4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		5 / 12 GLN A  53
ALA A 161
LEU A  57
GLU A 157
PHE A  14
 None
 1.07A 4pd5A-1or4A:
undetectable		 4pd5A-1or4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		5 / 12 GLN A  53
ALA A 161
LEU A  57
GLU A 157
PHE A  14
 None
 1.10A 4pd9A-1or4A:
0.0		 4pd9A-1or4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		5 / 9 ILE A 100
LEU A  79
VAL A  89
LEU A  92
ILE A  83
 None
HEM  A 180 (-4.1A)
None
CYN  A 181 (-3.5A)
None
 1.20A 4r38C-1or4A:
undetectable		 4r38C-1or4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		5 / 8 ILE A 100
LEU A  79
VAL A  89
LEU A  92
ILE A  83
 None
HEM  A 180 (-4.1A)
None
CYN  A 181 (-3.5A)
None
 1.21A 4r38D-1or4A:
undetectable		 4r38D-1or4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 7 ILE A 108
PHE A 112
ILE A 168
GLU A 172
 None
 0.96A 4zzbC-1or4A:
3.6
4zzbD-1or4A:
3.7		 4zzbC-1or4A:
19.87
4zzbD-1or4A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 6 ILE A 108
PHE A 112
ILE A 168
GLU A 172
 None
 0.83A 4zzcA-1or4A:
3.9
4zzcB-1or4A:
3.9		 4zzcA-1or4A:
20.50
4zzcB-1or4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 6 ILE A 108
PHE A 112
ILE A 168
GLU A 172
 None
 0.88A 4zzcB-1or4A:
3.9
4zzcC-1or4A:
3.9		 4zzcB-1or4A:
20.50
4zzcC-1or4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 5 GLU A 114
HIS A  31
LEU A  38
VAL A  34
 None
 1.14A 6bc9A-1or4A:
undetectable		 6bc9A-1or4A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		3 / 3 TYR A  49
ASP A  45
GLN A  21
 None
 0.95A 6g1pA-1or4A:
undetectable		 6g1pA-1or4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT
(Bacillus
subtilis) 		4 / 7 ILE A  65
TYR A 148
THR A 166
LEU A 169
 None
 1.00A 6nmfA-1or4A:
0.0
6nmfJ-1or4A:
0.0		 6nmfA-1or4A:
14.76
6nmfJ-1or4A:
17.58