SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1or7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli;
Escherichia
coli) 		4 / 7 TRP C  33
THR C  14
LEU A   5
LEU A  10
 None
 0.82A 1gtiB-1or7C:
undetectable		 1gtiB-1or7C:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli;
Escherichia
coli) 		4 / 7 TRP C  33
THR C  14
LEU A   5
LEU A  10
 None
 0.99A 1gtiE-1or7C:
undetectable		 1gtiE-1or7C:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
(Escherichia
coli) 		3 / 3 LEU A 138
PRO A 139
LEU A 142
 None
 0.50A 1hrkA-1or7A:
undetectable		 1hrkA-1or7A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		3 / 3 ARG C  40
VAL A  27
TRP C  33
 None
 1.07A 1qw6A-1or7C:
undetectable		 1qw6A-1or7C:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		3 / 3 ARG C  40
VAL A  27
TRP C  33
 None
 1.14A 1qwcA-1or7C:
undetectable		 1qwcA-1or7C:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
(Escherichia
coli) 		3 / 3 LEU A 142
LEU A 138
SER A 137
 None
 0.57A 1tlmA-1or7A:
undetectable		 1tlmA-1or7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		3 / 3 ARG C  40
VAL A  27
TRP C  33
 None
 1.10A 1vagA-1or7C:
undetectable		 1vagA-1or7C:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		3 / 3 ARG C  40
VAL A  27
TRP C  33
 None
 1.17A 1zviA-1or7C:
undetectable		 1zviA-1or7C:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
(Escherichia
coli) 		4 / 8 PHE A  64
GLN A   4
TYR A  71
TYR A  29
 None
 1.34A 2aoxA-1or7A:
undetectable		 2aoxA-1or7A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 9 GLY C  45
SER C  42
LEU A 127
LEU C  51
ASP C  46
 None
 1.45A 2j2pB-1or7C:
undetectable
2j2pC-1or7C:
undetectable		 2j2pB-1or7C:
15.00
2j2pC-1or7C:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
(Escherichia
coli) 		3 / 3 LEU A 138
PRO A 139
LEU A 142
 None
 0.49A 2qd5B-1or7A:
undetectable		 2qd5B-1or7A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 7 ARG C  40
TYR A  29
TYR A  75
ASP A   7
GLU A   3
 None
 1.26A 2qebA-1or7C:
undetectable		 2qebA-1or7C:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 7 ARG C  40
TYR A  29
TYR A  75
ASP A   7
GLU A   3
 None
 1.23A 2qebB-1or7C:
undetectable		 2qebB-1or7C:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 12 ARG C  40
TYR A  29
TYR A  75
ASP A   7
GLU A   3
 None
 1.28A 2qeoA-1or7C:
undetectable		 2qeoA-1or7C:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 10 ARG C  40
TYR A  29
TYR A  75
ASP A   7
GLU A   3
 None
 1.27A 2qeoB-1or7C:
undetectable		 2qeoB-1or7C:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DYE_A_LNRA600_1
(D7 PROTEIN)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 9 ARG C  40
TYR A  29
TYR A  75
ASP A   7
GLU A   3
 None
 1.31A 3dyeA-1or7C:
undetectable		 3dyeA-1or7C:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
(Escherichia
coli) 		4 / 6 ALA A 177
ILE A 181
LEU A 138
ALA A 145
 None
 0.85A 3r9sA-1or7A:
undetectable		 3r9sA-1or7A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
(Escherichia
coli) 		3 / 3 LEU A 138
PRO A 139
LEU A 142
 None
 0.47A 3w1wB-1or7A:
undetectable		 3w1wB-1or7A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
(Escherichia
coli) 		4 / 6 PHE A 132
GLU A 150
ARG A 128
ILE A 181
 None
 1.50A 4nosC-1or7A:
undetectable
4nosD-1or7A:
undetectable		 4nosC-1or7A:
20.57
4nosD-1or7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		5 / 9 ILE C  55
VAL A  33
ALA A  34
VAL A  41
ALA A  82
 None
 1.18A 4oqrA-1or7C:
undetectable		 4oqrA-1or7C:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli;
Escherichia
coli) 		4 / 8 HIS C  37
ARG A 149
ARG A 178
HIS A   0
 None
 1.26A 5db5A-1or7C:
undetectable
5db5B-1or7C:
undetectable		 5db5A-1or7C:
12.46
5db5B-1or7C:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli;
Escherichia
coli) 		4 / 8 HIS C  37
ARG A 149
ARG A 178
THR A   6
 None
 1.30A 5db5A-1or7C:
undetectable
5db5B-1or7C:
undetectable		 5db5A-1or7C:
12.46
5db5B-1or7C:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN
(Escherichia
coli) 		3 / 3 ARG C  40
VAL A  27
TRP C  33
 None
 1.21A 5fvoA-1or7C:
undetectable		 5fvoA-1or7C:
12.32