SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1or8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		5 / 12 ILE A 142
ILE A 123
LEU A 133
PRO A 134
VAL A 135
 None
 0.86A 1df7A-1or8A:
undetectable		 1df7A-1or8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		4 / 7 VAL A 182
LEU A 255
LEU A 227
VAL A 298
 None
 0.77A 1jgsA-1or8A:
0.3		 1jgsA-1or8A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		5 / 10 ILE A 317
ALA A 268
ILE A 333
ILE A 313
PHE A 253
 None
 1.13A 2w9sC-1or8A:
undetectable		 2w9sC-1or8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		3 / 3 GLY A  82
ILE A  97
VAL A  96
 None
 0.50A 3nv6A-1or8A:
undetectable		 3nv6A-1or8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		3 / 3 GLY A  98
ILE A 111
VAL A 112
 None
 0.30A 3nv6A-1or8A:
undetectable		 3nv6A-1or8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		4 / 6 GLY A  80
THR A  81
GLU A 100
ASP A  76
 SAH  A 354 (-3.6A)
SAH  A 354 ( 4.8A)
SAH  A 354 (-2.5A)
SAH  A 354 ( 3.9A)
 0.84A 3ps9A-1or8A:
5.6		 3ps9A-1or8A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		4 / 6 GLY A  80
GLU A 100
ASP A  76
GLU A 129
 SAH  A 354 (-3.6A)
SAH  A 354 (-2.5A)
SAH  A 354 ( 3.9A)
SAH  A 354 (-3.7A)
 0.86A 3vywC-1or8A:
6.5		 3vywC-1or8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		5 / 12 GLY A  78
GLY A  80
GLY A  82
LEU A  84
LYS A 127
 SAH  A 354 (-2.9A)
SAH  A 354 (-3.6A)
None
SAH  A 354 (-4.2A)
None
 1.07A 5c0oH-1or8A:
10.4		 5c0oH-1or8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		3 / 3 PHE A 270
ILE A 272
ASP A 238
 None
 0.57A 5cswA-1or8A:
undetectable		 5cswA-1or8A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		3 / 3 PHE A 270
ILE A 272
ASP A 238
 None
 0.46A 5cswB-1or8A:
undetectable		 5cswB-1or8A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		5 / 12 LEU A 156
SER A 154
PHE A 151
ILE A 272
LEU A  84
 None
None
None
None
SAH  A 354 (-4.2A)
 1.25A 5ljcA-1or8A:
2.1		 5ljcA-1or8A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		4 / 6 VAL A 298
ILE A 185
LYS A 191
TYR A 300
 None
 1.39A 5q1sA-1or8A:
undetectable		 5q1sA-1or8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		5 / 10 ALA A 265
LEU A 266
VAL A 267
LEU A 335
MET A 301
 None
 1.04A 5v02B-1or8A:
undetectable
5v02R-1or8A:
undetectable		 5v02B-1or8A:
15.26
5v02R-1or8A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1
(Rattus
norvegicus) 		3 / 3 LEU A 156
GLY A 147
PHE A 283
 None
 0.66A 6exiC-1or8A:
5.9		 6exiC-1or8A:
11.76