SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1oro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 PHE A  97
GLY A  74
ALA A  78
LEU A 122
 None
 0.90A 3bgdA-1oroA:
3.0		 3bgdA-1oroA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 LEU A  57
TYR A  53
ALA A  84
LEU A 151
 None
 1.05A 3ravA-1oroA:
undetectable		 3ravA-1oroA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 LEU A  57
TYR A  53
ALA A  84
LEU A 151
 None
 1.03A 3rd0A-1oroA:
undetectable		 3rd0A-1oroA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 LEU A 151
VAL A 123
LEU A  85
VAL A  83
THR A  80
 None
 1.42A 3tbgC-1oroA:
0.0		 3tbgC-1oroA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 LEU A  46
LEU A  49
GLY A  50
VAL A 123
 None
 0.86A 4c9nA-1oroA:
undetectable		 4c9nA-1oroA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 LEU A  67
LEU A  85
GLU A  55
ALA A  56
LEU A  57
 None
 1.05A 4wg0B-1oroA:
undetectable
4wg0C-1oroA:
undetectable
4wg0D-1oroA:
undetectable		 4wg0B-1oroA:
10.48
4wg0C-1oroA:
10.48
4wg0D-1oroA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 LEU A  67
LEU A  85
GLU A  55
ALA A  56
LEU A  57
 None
 1.04A 4wg0D-1oroA:
undetectable
4wg0E-1oroA:
undetectable
4wg0F-1oroA:
undetectable		 4wg0D-1oroA:
10.48
4wg0E-1oroA:
10.48
4wg0F-1oroA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 LEU A  67
LEU A  85
GLU A  55
ALA A  56
LEU A  57
 None
 1.02A 4wg0F-1oroA:
undetectable
4wg0G-1oroA:
undetectable
4wg0H-1oroA:
undetectable		 4wg0F-1oroA:
10.48
4wg0G-1oroA:
10.48
4wg0H-1oroA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 GLU A  55
ALA A  56
LEU A  57
LEU A  85
LEU A  67
 None
 1.09A 4wg0G-1oroA:
undetectable
4wg0H-1oroA:
undetectable
4wg0I-1oroA:
undetectable		 4wg0G-1oroA:
10.48
4wg0H-1oroA:
10.48
4wg0I-1oroA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 GLU A  55
ALA A  56
LEU A  57
LEU A  85
LEU A  67
 None
 1.13A 4wg0K-1oroA:
undetectable
4wg0L-1oroA:
undetectable
4wg0M-1oroA:
undetectable		 4wg0K-1oroA:
10.48
4wg0L-1oroA:
10.48
4wg0M-1oroA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		3 / 3 LYS A 177
LEU A 122
ILE A 127
 None
 0.77A 5kc0A-1oroA:
0.9		 5kc0A-1oroA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 HIS A  88
THR A  79
ARG A  44
GLY A  43
LEU A  46
 None
 1.14A 5m50E-1oroA:
2.1		 5m50E-1oroA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 GLY A 118
ILE A  62
ALA A 148
LEU A 147
PHE A  35
 None
 1.27A 5zjiA-1oroA:
undetectable
5zjiJ-1oroA:
0.0		 5zjiA-1oroA:
15.49
5zjiJ-1oroA:
11.79