SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1orp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1orp ENDONUCLEASE III
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A   9
VAL A 161
ILE A 168
ARG A 144
 None
 1.24A 3ik3A-1orpA:
undetectable		 3ik3A-1orpA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1orp ENDONUCLEASE III
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A   9
VAL A 161
ILE A 168
ARG A 144
 None
 1.24A 3ik3B-1orpA:
undetectable		 3ik3B-1orpA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COQ_B_SANB300_1
(CARBONATE
DEHYDRATASE)		 1orp ENDONUCLEASE III
(Geobacillus
stearothermophil
us) 		5 / 9 HIS A 178
HIS A 179
VAL A 125
VAL A 129
LEU A  25
 None
 1.41A 4coqB-1orpA:
undetectable		 4coqB-1orpA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1orp ENDONUCLEASE III
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 178
HIS A 179
VAL A 125
VAL A 129
LEU A  25
 None
 1.47A 4ygfG-1orpA:
undetectable		 4ygfG-1orpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1orp ENDONUCLEASE III
(Geobacillus
stearothermophil
us) 		4 / 7 ASP A 139
ILE A 182
GLY A 185
THR A 140
 None
 1.12A 4zxiA-1orpA:
undetectable		 4zxiA-1orpA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN9_A_EZLA302_1
(CARBONIC ANHYDRASE 4)		 1orp ENDONUCLEASE III
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 178
HIS A 179
VAL A 125
VAL A 129
LEU A  25
 None
 1.45A 5jn9A-1orpA:
undetectable		 5jn9A-1orpA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN9_B_EZLB302_1
(CARBONIC ANHYDRASE 4)		 1orp ENDONUCLEASE III
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 178
HIS A 179
VAL A 125
VAL A 129
LEU A  25
 None
 1.47A 5jn9B-1orpA:
undetectable		 5jn9B-1orpA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 1orp ENDONUCLEASE III
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 162
HIS A 178
VAL A 138
 None
 0.83A 5trqB-1orpA:
undetectable		 5trqB-1orpA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1orp ENDONUCLEASE III
(Geobacillus
stearothermophil
us) 		5 / 9 HIS A 178
HIS A 179
VAL A 125
VAL A 129
LEU A  25
 None
 1.46A 5tt3E-1orpA:
undetectable		 5tt3E-1orpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1orp ENDONUCLEASE III
(Geobacillus
stearothermophil
us) 		5 / 9 HIS A 178
HIS A 179
VAL A 125
VAL A 129
LEU A  25
 None
 1.47A 5tt3G-1orpA:
undetectable		 5tt3G-1orpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1orp ENDONUCLEASE III
(Geobacillus
stearothermophil
us) 		4 / 9 VAL A 142
HIS A 141
ASP A 139
VAL A 127
 None
 1.00A 6c2mD-1orpA:
undetectable		 6c2mD-1orpA:
16.19