SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1orq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		5 / 9 VAL C 171
ILE C 168
GLY C 213
ILE C 214
ILE C 208
 None
 0.99A 1hpvA-1orqC:
undetectable		 1hpvA-1orqC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		6 / 9 LEU C 218
VAL C  39
GLY C 209
ILE C 168
VAL C  44
ILE C  40
 None
 1.49A 1ohrB-1orqC:
undetectable		 1ohrB-1orqC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		5 / 8 ILE C 180
ILE C 168
GLY C 209
ILE C 208
PRO C 174
 None
 1.36A 1sh9A-1orqC:
undetectable		 1sh9A-1orqC:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		6 / 12 LEU C 218
VAL C  39
GLY C 209
ILE C 168
VAL C  44
ILE C  40
 None
 1.47A 2q63A-1orqC:
undetectable		 2q63A-1orqC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		6 / 12 LEU C 218
VAL C  39
GLY C 209
ILE C 168
VAL C  44
ILE C  40
 None
 1.46A 3bvbA-1orqC:
undetectable		 3bvbA-1orqC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		6 / 12 LEU C 218
VAL C  39
GLY C 209
ILE C 168
VAL C  44
ILE C  40
 None
 1.40A 3bvbB-1orqC:
undetectable		 3bvbB-1orqC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		4 / 6 LEU C  29
SER C  32
TYR C  33
LEU C  36
 None
 0.80A 3f33A-1orqC:
3.1		 3f33A-1orqC:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		6 / 12 LEU C 218
VAL C  39
GLY C 209
ILE C 168
VAL C  44
ILE C  40
 None
 1.45A 3jw2A-1orqC:
undetectable		 3jw2A-1orqC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		6 / 12 LEU C 218
VAL C  39
GLY C 209
ILE C 168
VAL C  44
ILE C  40
 None
 1.48A 3k4vB-1orqC:
undetectable		 3k4vB-1orqC:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		6 / 12 LEU C 218
VAL C  39
GLY C 209
ILE C 168
VAL C  44
ILE C  40
 None
 1.47A 3tl9B-1orqC:
undetectable		 3tl9B-1orqC:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		3 / 3 LEU C  58
ASP C  62
TYR C  59
 None
 0.62A 4qc6B-1orqC:
undetectable		 4qc6B-1orqC:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		4 / 7 ILE C 168
GLY C 213
THR C 206
TRP C 189
 None
 0.98A 4zxiA-1orqC:
undetectable		 4zxiA-1orqC:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		3 / 3 ASP C  72
ARG C  76
TYR C  73
 None
 0.97A 5a7mA-1orqC:
undetectable		 5a7mA-1orqC:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 1orq POTASSIUM CHANNEL
(Aeropyrum
pernix) 		3 / 3 ASP C  72
ARG C  76
TYR C  73
 None
 0.98A 5a7mB-1orqC:
undetectable		 5a7mB-1orqC:
16.07