SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1orr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		3 / 3 THR A 104
LEU A 108
VAL A 111
 None
 0.68A 1mz9E-1orrA:
undetectable		 1mz9E-1orrA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		5 / 11 LEU A  13
SER A 247
TYR A 249
LEU A  80
HIS A  79
 NAD  A1200 (-3.7A)
None
None
NAD  A1200 (-4.4A)
None
 1.50A 2idkA-1orrA:
6.7
2idkB-1orrA:
6.8
2idkC-1orrA:
6.8
2idkD-1orrA:
7.0		 2idkA-1orrA:
23.34
2idkB-1orrA:
23.34
2idkC-1orrA:
23.34
2idkD-1orrA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		4 / 4 GLU A  98
ARG A  60
ASN A  61
ASP A  58
 None
None
None
NAD  A1200 (-3.8A)
 1.46A 2zq9A-1orrA:
undetectable		 2zq9A-1orrA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		5 / 8 VAL A  30
GLY A  11
PHE A 201
GLY A  38
ALA A  39
 None
NAD  A1200 (-3.1A)
None
None
NAD  A1200 ( 4.1A)
 1.30A 3aruA-1orrA:
undetectable		 3aruA-1orrA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		5 / 12 GLY A   8
ASP A  32
ASP A  58
ILE A  59
ARG A  36
 NAD  A1200 (-3.2A)
NAD  A1200 (-2.7A)
NAD  A1200 (-3.8A)
NAD  A1200 (-4.0A)
None
 1.30A 3iv6B-1orrA:
5.5		 3iv6B-1orrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		3 / 3 TYR A 129
ASP A 173
ASP A 178
 None
 0.87A 3ou6B-1orrA:
4.7		 3ou6B-1orrA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		4 / 6 VAL A 305
ASN A 126
TYR A 153
GLU A 133
 None
CDP  A1201 (-3.3A)
None
None
 1.20A 3q5sA-1orrA:
0.0		 3q5sA-1orrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		5 / 12 LEU A  80
HIS A  79
SER A 247
TYR A 249
LEU A  13
 NAD  A1200 (-4.4A)
None
None
None
NAD  A1200 (-3.7A)
 1.50A 3thrA-1orrA:
6.1
3thrB-1orrA:
6.0
3thrC-1orrA:
6.8
3thrD-1orrA:
6.7		 3thrA-1orrA:
23.05
3thrB-1orrA:
23.05
3thrC-1orrA:
23.05
3thrD-1orrA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		5 / 12 HIS A 241
ILE A 246
LEU A   4
LEU A  13
GLY A  14
 None
None
None
NAD  A1200 (-3.7A)
None
 1.23A 4foxG-1orrA:
0.0		 4foxG-1orrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		4 / 8 ILE A 313
ILE A 310
ASN A 265
ALA A 308
 None
 0.78A 4ou1A-1orrA:
undetectable		 4ou1A-1orrA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		3 / 3 THR A 269
ASN A 272
SER A 273
 None
 0.74A 4tvtA-1orrA:
undetectable		 4tvtA-1orrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		4 / 8 LEU A 107
ALA A 110
ILE A  69
ALA A  81
 None
None
None
NAD  A1200 (-3.8A)
 0.78A 4wboB-1orrA:
0.0		 4wboB-1orrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		5 / 12 SER A 123
PHE A 250
LEU A   4
THR A   7
GLY A   8
 NAD  A1200 (-3.1A)
None
None
None
NAD  A1200 (-3.2A)
 1.36A 4zjlA-1orrA:
undetectable		 4zjlA-1orrA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		4 / 7 ILE A   6
LEU A  80
GLY A  11
GLY A  14
 None
NAD  A1200 (-4.4A)
NAD  A1200 (-3.1A)
None
 0.85A 5a06A-1orrA:
6.5		 5a06A-1orrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		4 / 7 ILE A   6
LEU A  80
GLY A  11
GLY A  14
 None
NAD  A1200 (-4.4A)
NAD  A1200 (-3.1A)
None
 0.83A 5a06B-1orrA:
6.6		 5a06B-1orrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		4 / 7 ILE A   6
LEU A  80
GLY A  11
GLY A  14
 None
NAD  A1200 (-4.4A)
NAD  A1200 (-3.1A)
None
 0.85A 5a06C-1orrA:
6.6		 5a06C-1orrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		4 / 7 ILE A   6
LEU A  80
GLY A  11
GLY A  14
 None
NAD  A1200 (-4.4A)
NAD  A1200 (-3.1A)
None
 0.84A 5a06E-1orrA:
6.5		 5a06E-1orrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		4 / 7 ILE A   6
LEU A  80
GLY A  11
GLY A  14
 None
NAD  A1200 (-4.4A)
NAD  A1200 (-3.1A)
None
 0.86A 5a06F-1orrA:
6.6		 5a06F-1orrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		5 / 12 ILE A  69
VAL A  65
LEU A  68
VAL A  55
ILE A  29
 None
 1.08A 5mugA-1orrA:
undetectable		 5mugA-1orrA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		4 / 5 PHE A 280
THR A 142
GLU A 284
ASN A 288
 None
 1.29A 5ybbA-1orrA:
4.8		 5ybbA-1orrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1orr CDP-TYVELOSE-2-EPIME
RASE
(Salmonella
enterica) 		5 / 12 THR A 336
ILE A 339
LEU A 240
PHE A  12
LEU A  13
 None
None
None
None
NAD  A1200 (-3.7A)
 1.11A 6a93A-1orrA:
undetectable		 6a93A-1orrA:
20.10