SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ort'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A 136
PHE A 126
PHE A  52
LEU A  50
VAL A  74
 None
 1.27A 1q23D-1ortA:
0.0
1q23E-1ortA:
0.0		 1q23D-1ortA:
20.06
1q23E-1ortA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A 136
PHE A 126
PHE A  52
LEU A  50
VAL A  74
 None
 1.33A 1q23I-1ortA:
0.0		 1q23I-1ortA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A 230
GLY A 162
GLY A 169
GLN A 254
ASP A 231
 None
 1.18A 1wg8B-1ortA:
5.2		 1wg8B-1ortA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 324
ALA A  66
ALA A  67
GLN A  70
LEU A  50
 None
 1.06A 1xiuB-1ortA:
undetectable		 1xiuB-1ortA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 324
ILE A 327
ALA A 326
ILE A 175
HIS A  15
 None
 1.03A 1xzxX-1ortA:
0.0		 1xzxX-1ortA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		4 / 5 ILE A  51
ILE A 113
MET A  90
LEU A 328
 None
 0.90A 1zgyA-1ortA:
0.0		 1zgyA-1ortA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  66
ALA A  67
GLN A  70
ASN A  47
ILE A 104
 None
 0.93A 2aclC-1ortA:
undetectable		 2aclC-1ortA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 324
ILE A 327
ALA A 326
ILE A 175
HIS A  15
 None
 0.98A 2h79A-1ortA:
0.0		 2h79A-1ortA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.68A 2nmzA-1ortA:
0.0		 2nmzA-1ortA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.64A 2nnkA-1ortA:
undetectable		 2nnkA-1ortA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A   9
GLY A 128
ILE A 324
ILE A 327
 None
 0.83A 2q9rA-1ortA:
undetectable		 2q9rA-1ortA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 197
CYH A 201
PHE A 204
 None
 0.84A 3cr5X-1ortA:
0.0		 3cr5X-1ortA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  66
ALA A  67
GLN A  70
ASN A  47
ILE A 104
 None
 0.91A 3e00A-1ortA:
undetectable		 3e00A-1ortA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 324
ILE A 327
ALA A 326
ILE A 175
HIS A  15
 None
 0.99A 3gwsX-1ortA:
0.0		 3gwsX-1ortA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.59A 3k4vA-1ortA:
undetectable		 3k4vA-1ortA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.63A 3k4vD-1ortA:
undetectable		 3k4vD-1ortA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.66A 3ndtA-1ortA:
0.0		 3ndtA-1ortA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.69A 3nduD-1ortA:
undetectable		 3nduD-1ortA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.73A 3pwrA-1ortA:
undetectable		 3pwrA-1ortA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.65A 3tl9A-1ortA:
undetectable		 3tl9A-1ortA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  24
ASP A  29
ILE A 156
 None
 0.59A 4xi3D-1ortA:
undetectable		 4xi3D-1ortA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 249
GLU A 216
THR A 215
LEU A 161
 None
 1.26A 5hm8B-1ortA:
4.7		 5hm8B-1ortA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 249
GLU A 216
THR A 215
LEU A 161
 None
 1.26A 5hm8D-1ortA:
5.0		 5hm8D-1ortA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 249
GLU A 216
THR A 215
LEU A 161
 None
 1.26A 5hm8E-1ortA:
6.2		 5hm8E-1ortA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 249
GLU A 216
THR A 215
LEU A 161
 None
 1.26A 5hm8F-1ortA:
7.6		 5hm8F-1ortA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 249
GLU A 216
THR A 215
LEU A 161
 None
 1.26A 5hm8H-1ortA:
3.8		 5hm8H-1ortA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 324
ALA A  66
ALA A  67
GLN A  70
LEU A  50
 None
 1.04A 6a60D-1ortA:
undetectable		 6a60D-1ortA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 1ort ORNITHINE
TRANSCARBAMOYLASE
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 140
THR A 144
ILE A 312
ALA A 313
 None
 0.90A 6ma7A-1ortA:
0.0		 6ma7A-1ortA:
14.50