SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1osg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 1osg TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B
(Homo
sapiens) 		3 / 3 TRP A 168
ALA A 262
VAL A 166
 None
 0.89A 1kqeA-1osgA:
undetectable
1kqeE-1osgA:
undetectable		 1kqeA-1osgA:
3.91
1kqeE-1osgA:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 1osg TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B
(Homo
sapiens) 		5 / 12 VAL A 166
TRP A 168
LEU A 261
PHE A 278
TYR A 246
 None
 1.27A 2ziaB-1osgA:
undetectable		 2ziaB-1osgA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1osg TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B
(Homo
sapiens) 		4 / 7 LEU A 261
THR A 277
ILE A 270
GLY A 209
 None
 0.94A 4eqlA-1osgA:
undetectable		 4eqlA-1osgA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1osg TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B
(Homo
sapiens) 		4 / 7 LEU A 261
THR A 277
ILE A 270
GLY A 209
 None
 0.86A 4l39B-1osgA:
undetectable		 4l39B-1osgA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1osg TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B
(Homo
sapiens) 		5 / 12 ILE A 212
VAL A 199
ALA A 151
VAL A 166
PHE A 172
 None
 1.02A 5igiA-1osgA:
undetectable		 5igiA-1osgA:
23.97