SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1osm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 1osm OMPK36
(Klebsiella
pneumoniae) 		4 / 8 GLN A 255
ASN A 256
TYR A 275
LEU A 292
 None
None
D12  A 344 ( 4.7A)
None
 1.09A 1hk3A-1osmA:
undetectable		 1hk3A-1osmA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 1osm OMPK36
(Klebsiella
pneumoniae) 		5 / 12 SER A 131
ASP A 113
LEU A 276
LEU A 292
TYR A 294
 None
 1.35A 1p33B-1osmA:
0.0		 1p33B-1osmA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 1osm OMPK36
(Klebsiella
pneumoniae) 		4 / 6 ARG A 140
ASP A  97
THR A 138
ASP A 107
 None
 0.98A 2j2pE-1osmA:
undetectable
2j2pF-1osmA:
undetectable		 2j2pE-1osmA:
21.97
2j2pF-1osmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 1osm OMPK36
(Klebsiella
pneumoniae) 		4 / 4 GLY A  59
TYR A  58
GLY A  87
ASP A  97
 None
 0.60A 3kl3A-1osmA:
undetectable		 3kl3A-1osmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1osm OMPK36
(Klebsiella
pneumoniae) 		4 / 7 LEU A 292
LEU A 276
ASN A 256
THR A 229
 None
None
None
D12  A 349 (-3.2A)
 1.05A 3lm8A-1osmA:
undetectable
3lm8C-1osmA:
undetectable		 3lm8A-1osmA:
21.02
3lm8C-1osmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1osm OMPK36
(Klebsiella
pneumoniae) 		4 / 6 ASP A 113
GLY A 119
ASP A 121
THR A 122
 None
 1.00A 3vqrA-1osmA:
undetectable		 3vqrA-1osmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1osm OMPK36
(Klebsiella
pneumoniae) 		4 / 5 ASP A 113
GLY A 119
ASP A 121
THR A 122
 None
 1.03A 3vqrB-1osmA:
undetectable		 3vqrB-1osmA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 1osm OMPK36
(Klebsiella
pneumoniae) 		5 / 8 LYS A  16
TYR A  40
ARG A  82
ASP A 113
ARG A 132
 None
 0.98A 4kr4C-1osmA:
36.7		 4kr4C-1osmA:
54.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR8_C_DM1C401_1
(OUTER MEMBRANE
PROTEIN F)		 1osm OMPK36
(Klebsiella
pneumoniae) 		5 / 10 LYS A  16
TYR A  40
ARG A  82
TYR A 102
ARG A 132
 None
 0.91A 4kr8C-1osmA:
38.3		 4kr8C-1osmA:
54.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1osm OMPK36
(Klebsiella
pneumoniae) 		4 / 7 ASN A 163
ASP A 172
GLY A 173
ASN A 170
 None
 0.87A 5x7pA-1osmA:
undetectable		 5x7pA-1osmA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1osm OMPK36
(Klebsiella
pneumoniae) 		3 / 3 VAL A 136
ALA A 133
GLN A 156
 None
 0.64A 6gb9A-1osmA:
undetectable		 6gb9A-1osmA:
21.37