SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1osn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 ASP A 148
ARG A 143
ILE A  65
 None
None
BVP  A 500 ( 4.2A)
 0.90A 1a4gB-1osnA:
undetectable		 1a4gB-1osnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 8 GLU A 164
ILE A 213
THR A 212
LEU A 209
 None
 0.94A 1hmyA-1osnA:
undetectable		 1hmyA-1osnA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_A_GA2A1_1
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		6 / 11 GLU A  48
ILE A  65
TYR A  66
GLN A  90
ARG A 130
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
None
 0.88A 1ki2A-1osnA:
34.7		 1ki2A-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_B_GA2B2_1
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  48
TRP A  53
ILE A  65
TYR A  66
GLN A  90
ARG A 130
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
None
 0.81A 1ki2B-1osnA:
34.9		 1ki2B-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  48
TRP A  53
ILE A  62
ILE A  65
TYR A  66
GLN A  90
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
None
 0.96A 1ki3A-1osnA:
34.4		 1ki3A-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_B_PE2B2_1
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  48
TRP A  53
ILE A  62
ILE A  65
TYR A  66
GLN A  90
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
None
 0.84A 1ki3B-1osnA:
35.1		 1ki3B-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  48
TRP A  53
ILE A  62
ILE A  65
TYR A  66
GLN A  90
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
 0.64A 1ki7A-1osnA:
34.3		 1ki7A-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
ILE A  62
ILE A  65
ARG A 130
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-2.8A)
 0.79A 1ki7B-1osnA:
35.1		 1ki7B-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
ILE A  65
GLN A  90
ARG A 130
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
 0.61A 1ki7B-1osnA:
35.1		 1ki7B-1osnA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 LEU A 202
VAL A 205
LEU A 209
 None
 0.50A 1mz9B-1osnA:
undetectable		 1mz9B-1osnA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ALA A 134
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.9A)
BVP  A 500 (-3.7A)
 1.38A 2jj8B-1osnA:
13.4		 2jj8B-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ARG A 130
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 1.10A 2jj8B-1osnA:
13.4		 2jj8B-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 TRP A  53
TYR A  66
GLN A  90
ARG A 130
PHE A 139
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 0.98A 2jj8B-1osnA:
13.4		 2jj8B-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
ILE A  65
TYR A  66
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
None
 0.96A 2ki5A-1osnA:
34.4		 2ki5A-1osnA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		6 / 12 TRP A  53
ILE A  62
ILE A  65
TYR A  66
GLN A  90
ARG A 143
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
None
 0.71A 2ki5A-1osnA:
34.4		 2ki5A-1osnA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  48
TRP A  53
ILE A  65
TYR A  66
GLN A  90
ARG A 130
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
None
 0.98A 2ki5B-1osnA:
35.1		 2ki5B-1osnA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		7 / 12 TRP A  53
ILE A  62
ILE A  65
TYR A  66
GLN A  90
ARG A 130
ARG A 143
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
None
 0.60A 2ki5B-1osnA:
35.1		 2ki5B-1osnA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 LEU A 216
LEU A 161
PHE A 258
 None
 0.68A 2pgrA-1osnA:
undetectable		 2pgrA-1osnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 ARG A  14
SER A 105
TYR A  16
 None
 0.66A 2q2hA-1osnA:
0.0
2q2hB-1osnA:
0.0		 2q2hA-1osnA:
17.51
2q2hB-1osnA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ALA A 134
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.9A)
BVP  A 500 (-3.7A)
 1.23A 2vppA-1osnA:
13.8		 2vppA-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ARG A 130
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 1.01A 2vppA-1osnA:
13.8		 2vppA-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 TRP A  53
TYR A  66
GLN A  90
ARG A 130
PHE A 139
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 0.93A 2vppA-1osnA:
13.8		 2vppA-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ALA A 134
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.9A)
BVP  A 500 (-3.7A)
 1.19A 2vppB-1osnA:
13.6		 2vppB-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ARG A 130
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 0.92A 2vppB-1osnA:
13.6		 2vppB-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 TRP A  53
TYR A  66
GLN A  90
ARG A 130
PHE A 139
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 0.87A 2vppB-1osnA:
13.6		 2vppB-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
GLN A  90
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-3.7A)
 1.02A 2zi9B-1osnA:
15.7		 2zi9B-1osnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
GLN A  90
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-3.7A)
 0.94A 2ziaA-1osnA:
16.2		 2ziaA-1osnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TYR A  66
GLN A  90
ARG A 130
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 0.98A 2ziaA-1osnA:
16.2		 2ziaA-1osnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
GLN A  90
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-3.7A)
 0.99A 2ziaB-1osnA:
15.8		 2ziaB-1osnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 ALA A 106
LEU A 329
LEU A 332
VAL A 333
MET A 126
 None
 0.93A 3adxB-1osnA:
undetectable		 3adxB-1osnA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 PRO A 318
LEU A  13
ARG A  42
 None
 0.77A 3aqiB-1osnA:
undetectable		 3aqiB-1osnA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 LEU A 266
LEU A 263
MET A 149
LEU A 145
LEU A 158
 None
 1.31A 3d90B-1osnA:
undetectable		 3d90B-1osnA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 SER A  91
GLN A  90
PHE A  93
 None
BVP  A 500 (-3.0A)
BVP  A 500 (-3.5A)
 0.83A 3g4lC-1osnA:
0.0		 3g4lC-1osnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ALA A 134
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.9A)
BVP  A 500 (-3.7A)
 1.33A 3hp1A-1osnA:
16.0		 3hp1A-1osnA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 TRP A  53
TYR A  66
GLN A  90
ALA A 134
PHE A 139
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-3.9A)
BVP  A 500 (-3.7A)
 1.31A 3hp1A-1osnA:
16.0		 3hp1A-1osnA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 GLY A  22
GLY A  24
THR A  26
 ADP  A 400 ( 3.5A)
ADP  A 400 (-3.0A)
ADP  A 400 (-3.6A)
 0.39A 3si7B-1osnA:
2.5		 3si7B-1osnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 LEU A 239
VAL A 205
THR A 212
LEU A 261
VAL A 260
 None
 1.14A 3sp9B-1osnA:
undetectable		 3sp9B-1osnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 PHE A 139
VAL A 260
TYR A  21
HIS A 180
LEU A 239
 BVP  A 500 (-3.7A)
None
BVP  A 500 ( 4.5A)
None
None
 1.47A 3wfhA-1osnA:
undetectable
3wfhB-1osnA:
undetectable		 3wfhA-1osnA:
20.18
3wfhB-1osnA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 PHE A 139
VAL A 260
TYR A  21
HIS A 180
LEU A 239
 BVP  A 500 (-3.7A)
None
BVP  A 500 ( 4.5A)
None
None
 1.47A 3whxA-1osnA:
undetectable
3whxB-1osnA:
undetectable		 3whxA-1osnA:
20.47
3whxB-1osnA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 6 GLY A 167
PRO A 318
GLY A  11
TYR A 123
 None
 0.82A 4dxuA-1osnA:
undetectable		 4dxuA-1osnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 6 TRP A  53
ILE A  65
THR A  86
ASP A  18
 BVP  A 500 (-4.6A)
BVP  A 500 ( 4.2A)
None
None
 1.11A 4iaqA-1osnA:
1.0		 4iaqA-1osnA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 8 LEU A 329
LEU A 332
VAL A 333
MET A 126
 None
 0.90A 4oj4A-1osnA:
undetectable		 4oj4A-1osnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 5 LEU A  73
ALA A  82
THR A  86
ILE A  65
 None
None
None
BVP  A 500 ( 4.2A)
 0.86A 4xe3A-1osnA:
undetectable		 4xe3A-1osnA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 5 LEU A  73
ALA A  82
THR A  86
ILE A  65
 None
None
None
BVP  A 500 ( 4.2A)
 0.92A 4xe3B-1osnA:
undetectable		 4xe3B-1osnA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 LEU A 274
PHE A 159
ILE A 273
 None
 0.68A 5dzk1-1osnA:
undetectable
5dzkF-1osnA:
undetectable
5dzkM-1osnA:
undetectable		 5dzk1-1osnA:
4.44
5dzkF-1osnA:
20.63
5dzkM-1osnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 ASN A 327
SER A 323
SER A 322
 None
 0.75A 5gsnA-1osnA:
undetectable		 5gsnA-1osnA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 6 ASP A  18
ARG A 130
LEU A  17
ASP A 129
 None
BVP  A 500 (-2.8A)
None
BVP  A 500 ( 4.9A)
 1.05A 5tdzA-1osnA:
undetectable		 5tdzA-1osnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 8 LEU A 228
HIS A 222
LEU A 263
ILE A 273
 None
 0.94A 5v0vA-1osnA:
undetectable		 5v0vA-1osnA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 TYR A  16
HIS A 101
MET A 100
 None
 1.08A 6af6A-1osnA:
0.0		 6af6A-1osnA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 6 ILE A 207
MET A 208
ASN A 211
ASP A 255
 None
 1.12A 6dhbA-1osnA:
0.0		 6dhbA-1osnA:
15.48