SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ot5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 452
ALA A 401
GLY A 166
ILE A 453
 None
 0.66A 1d4yB-1ot5A:
undetectable		 1d4yB-1ot5A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 438
THR A 335
SER A 312
TRP A 560
 None
CA  A 602 (-4.3A)
None
None
 1.47A 1eiiA-1ot5A:
undetectable		 1eiiA-1ot5A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 154
LYS A 446
ALA A 357
VAL A 394
 None
 0.94A 1hk1A-1ot5A:
undetectable		 1hk1A-1ot5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 223
VAL A 234
TRP A 160
 CA  A 601 ( 4.9A)
None
None
 0.84A 1jo3A-1ot5A:
undetectable		 1jo3A-1ot5A:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 223
VAL A 234
TRP A 160
 CA  A 601 ( 4.9A)
None
None
 0.84A 1jo3B-1ot5A:
undetectable		 1jo3B-1ot5A:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 547
ARG A 540
ASP A 320
THR A 328
 None
None
CA  A 600 (-2.8A)
None
 1.22A 1k4tA-1ot5A:
0.0		 1k4tA-1ot5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_A_ACRA700_1
(GLUCOAMYLASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 276
ARG A 280
ASP A 278
GLU A 547
ARG A 519
 None
 1.34A 1lf9A-1ot5A:
undetectable		 1lf9A-1ot5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_B_ACRB701_1
(GLUCOAMYLASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 276
ARG A 280
ASP A 278
GLU A 547
ARG A 519
 None
 1.31A 1lf9B-1ot5A:
undetectable		 1lf9B-1ot5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 223
VAL A 234
TRP A 160
 CA  A 601 ( 4.9A)
None
None
 0.96A 1nrmA-1ot5A:
undetectable		 1nrmA-1ot5A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 223
VAL A 234
TRP A 160
 CA  A 601 ( 4.9A)
None
None
 0.96A 1nrmB-1ot5A:
undetectable		 1nrmB-1ot5A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 223
VAL A 234
TRP A 160
 CA  A 601 ( 4.9A)
None
None
 0.80A 1nt6A-1ot5A:
undetectable		 1nt6A-1ot5A:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 223
VAL A 234
TRP A 160
 CA  A 601 ( 4.9A)
None
None
 0.80A 1nt6B-1ot5A:
undetectable		 1nt6B-1ot5A:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 12 CYH A 271
GLY A 296
ILE A 307
TYR A 395
ALA A 392
 None
 1.13A 1oltA-1ot5A:
0.7		 1oltA-1ot5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 547
ARG A 540
ASP A 320
THR A 328
 None
None
CA  A 600 (-2.8A)
None
 1.22A 1rr8C-1ot5A:
0.0		 1rr8C-1ot5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 547
ARG A 540
ASP A 320
THR A 328
 None
None
CA  A 600 (-2.8A)
None
 1.23A 1rrjA-1ot5A:
0.0		 1rrjA-1ot5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_1
(GLUCODEXTRANASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 276
ARG A 280
ASP A 278
GLU A 547
ARG A 519
 None
 1.38A 1ulvA-1ot5A:
undetectable		 1ulvA-1ot5A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 184
ASP A 187
ASN A 228
 CA  A 601 (-2.3A)
None
None
 0.85A 2bm9D-1ot5A:
undetectable		 2bm9D-1ot5A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 234
SER A 272
ALA A 391
ILE A 339
TYR A 348
 None
 1.29A 2qm9B-1ot5A:
undetectable		 2qm9B-1ot5A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 391
ALA A 388
SER A 385
GLY A 382
CYH A 217
 None
 1.40A 2vh3A-1ot5A:
0.0		 2vh3A-1ot5A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 275
GLY A 284
TYR A 327
 None
 0.69A 2vouA-1ot5A:
2.5		 2vouA-1ot5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 275
GLY A 284
TYR A 327
 None
 0.64A 2vouB-1ot5A:
0.0		 2vouB-1ot5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 275
GLY A 284
TYR A 327
 None
 0.65A 2vouC-1ot5A:
undetectable		 2vouC-1ot5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 12 SER A 439
PHE A 554
ASP A 325
THR A 328
PHE A 549
 None
 1.40A 3a25A-1ot5A:
undetectable		 3a25A-1ot5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 SER A 333
GLU A 350
ASP A 278
 CA  A 602 (-2.3A)
CA  A 600 (-2.1A)
None
 0.83A 3dmhA-1ot5A:
2.0		 3dmhA-1ot5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 452
ALA A 401
GLY A 166
ALA A 449
ILE A 453
 None
 0.89A 3ekpB-1ot5A:
undetectable		 3ekpB-1ot5A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 515
ASP A 513
TYR A 474
GLN A 477
 None
 1.08A 3l2vA-1ot5A:
0.1		 3l2vA-1ot5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 532
GLY A 564
ILE A 492
VAL A 510
LEU A 526
 None
 1.00A 3ogpA-1ot5A:
undetectable		 3ogpA-1ot5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 340
SER A 362
SER A 361
GLY A 337
 None
 0.95A 4fo4A-1ot5A:
undetectable		 4fo4A-1ot5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 540
ASP A 278
ARG A 519
 None
 0.80A 4mx0A-1ot5A:
undetectable		 4mx0A-1ot5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 386
ILE A 447
GLY A 337
ALA A 338
ILE A 368
 None
 1.04A 4nkxC-1ot5A:
undetectable		 4nkxC-1ot5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 184
ASN A 228
SER A 378
 CA  A 601 (-2.3A)
None
None
 0.85A 4obwA-1ot5A:
2.2		 4obwA-1ot5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 8 THR A 165
LEU A 131
VAL A 145
LEU A 144
GLY A 235
 None
 1.35A 4r3aA-1ot5A:
undetectable		 4r3aA-1ot5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 388
SER A 272
ALA A 392
SER A 270
ALA A 386
 None
 1.27A 4twdA-1ot5A:
0.0
4twdB-1ot5A:
0.0
4twdC-1ot5A:
0.0
4twdD-1ot5A:
0.0
4twdE-1ot5A:
0.0		 4twdA-1ot5A:
20.62
4twdB-1ot5A:
20.62
4twdC-1ot5A:
20.62
4twdD-1ot5A:
20.62
4twdE-1ot5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 312
GLY A 337
ALA A 558
GLY A 443
 None
 0.88A 5albL-1ot5A:
2.2		 5albL-1ot5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 570
PHE A 583
ARG A 587
THR A 553
 None
 1.04A 5b1aN-1ot5A:
0.0
5b1aW-1ot5A:
0.0		 5b1aN-1ot5A:
21.15
5b1aW-1ot5A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 11 THR A 215
ALA A 218
GLY A 219
ALA A 223
ASP A 135
 None
None
None
CA  A 601 ( 4.9A)
CA  A 601 (-3.3A)
 1.37A 5bxnV-1ot5A:
undetectable
5bxnW-1ot5A:
undetectable		 5bxnV-1ot5A:
19.42
5bxnW-1ot5A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 171
GLY A 235
GLY A 219
ALA A 167
LEU A 397
 None
None
None
NAG  A 603 (-3.3A)
None
 0.90A 5c0oE-1ot5A:
undetectable		 5c0oE-1ot5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 171
GLY A 235
GLY A 219
ALA A 167
LEU A 397
 None
None
None
NAG  A 603 (-3.3A)
None
 0.98A 5c0oG-1ot5A:
2.2		 5c0oG-1ot5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 4 CYH A 190
PHE A 189
ILE A 221
GLY A 242
 None
 1.28A 5hesB-1ot5A:
0.0		 5hesB-1ot5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 12 THR A 215
ALA A 218
GLY A 219
ALA A 223
ASP A 135
 None
None
None
CA  A 601 ( 4.9A)
CA  A 601 (-3.3A)
 1.39A 5l5zV-1ot5A:
undetectable
5l5zW-1ot5A:
undetectable		 5l5zV-1ot5A:
18.88
5l5zW-1ot5A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 323
SER A 330
ALA A 354
VAL A 355
 None
 1.39A 5nm5A-1ot5A:
2.9		 5nm5A-1ot5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 268
SER A 349
ILE A 368
ALA A 386
ALA A 311
 None
 0.94A 5oy02-1ot5A:
undetectable		 5oy02-1ot5A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 592
GLN A 465
TRP A 467
SER A 594
 None
 1.49A 5vunA-1ot5A:
0.0		 5vunA-1ot5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 124
GLU A 128
GLY A 231
LEU A 137
 None
None
CA  A 601 (-4.2A)
None
 0.85A 5w3jB-1ot5A:
3.6		 5w3jB-1ot5A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 570
PHE A 583
ARG A 587
THR A 553
 None
 1.01A 5z84N-1ot5A:
0.0
5z84W-1ot5A:
0.0		 5z84N-1ot5A:
21.15
5z84W-1ot5A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 549
ASP A 513
LYS A 550
 None
 0.87A 6awtD-1ot5A:
0.0		 6awtD-1ot5A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 296
THR A 298
GLU A 299
 None
 0.50A 6b58A-1ot5A:
2.2		 6b58A-1ot5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 6 SER A 361
ALA A 311
ALA A 386
SER A 385
 None
 1.03A 6bocA-1ot5A:
undetectable
6bocB-1ot5A:
undetectable
6bocC-1ot5A:
undetectable
6bocD-1ot5A:
undetectable		 6bocA-1ot5A:
4.50
6bocB-1ot5A:
4.50
6bocC-1ot5A:
4.50
6bocD-1ot5A:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 6 SER A 361
ALA A 311
SER A 312
ALA A 386
 None
 0.94A 6bocA-1ot5A:
undetectable
6bocB-1ot5A:
undetectable
6bocC-1ot5A:
undetectable
6bocD-1ot5A:
undetectable		 6bocA-1ot5A:
4.50
6bocB-1ot5A:
4.50
6bocC-1ot5A:
4.50
6bocD-1ot5A:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 1ot5 KEXIN
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 373
LEU A 185
HIS A 381
ALA A 218
 None
 0.95A 6ck2C-1ot5A:
undetectable
6ck2D-1ot5A:
undetectable		 6ck2C-1ot5A:
4.42
6ck2D-1ot5A:
5.80