SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ot8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1ot8 NEUROGENIC LOCUS
NOTCH PROTEIN
(Drosophila
melanogaster) 		3 / 3 THR A  46
LEU A  43
LEU A  36
 None
 0.53A 1mz9C-1ot8A:
undetectable		 1mz9C-1ot8A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 1ot8 NEUROGENIC LOCUS
NOTCH PROTEIN
(Drosophila
melanogaster) 		5 / 12 ARG A 127
ALA A 146
ASP A 117
ASP A 182
GLY A 118
 None
 1.36A 3jzjA-1ot8A:
undetectable		 3jzjA-1ot8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1ot8 NEUROGENIC LOCUS
NOTCH PROTEIN
(Drosophila
melanogaster) 		4 / 7 GLU A 226
SER A 225
VAL A 223
VAL A 233
 None
 1.10A 3n61A-1ot8A:
0.0
3n61B-1ot8A:
0.0		 3n61A-1ot8A:
18.86
3n61B-1ot8A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ot8 NEUROGENIC LOCUS
NOTCH PROTEIN
(Drosophila
melanogaster) 		4 / 8 GLU A 226
SER A 225
VAL A 223
VAL A 233
 None
 1.07A 3nlrA-1ot8A:
undetectable
3nlrB-1ot8A:
undetectable		 3nlrA-1ot8A:
18.86
3nlrB-1ot8A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ot8 NEUROGENIC LOCUS
NOTCH PROTEIN
(Drosophila
melanogaster) 		4 / 6 LEU A 124
ASP A  81
VAL A  99
ALA A  96
 None
 1.01A 4nkxA-1ot8A:
0.0		 4nkxA-1ot8A:
18.83