SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1otg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1otg 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE
(Escherichia
coli) 		3 / 3 LEU A 110
HIS A   3
LYS A  67
 None
 0.93A 1y7iA-1otgA:
undetectable		 1y7iA-1otgA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1otg 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE
(Escherichia
coli) 		5 / 12 VAL A  62
PHE A  92
ILE A  88
LEU A  84
LEU A  18
 None
 1.25A 2jn3A-1otgA:
undetectable		 2jn3A-1otgA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 1otg 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE
(Escherichia
coli) 		5 / 12 ASP A  10
TRP A  46
GLU A  14
ALA A  60
GLU A  15
 None
 1.32A 3k37B-1otgA:
undetectable		 3k37B-1otgA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 1otg 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE
(Escherichia
coli) 		3 / 3 ASN A  11
ALA A  60
ARG A  99
 None
 0.70A 3tj7C-1otgA:
undetectable
3tj7D-1otgA:
undetectable		 3tj7C-1otgA:
22.39
3tj7D-1otgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1otg 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE
(Escherichia
coli) 		4 / 8 ILE A  68
ILE A  34
PHE A  35
GLU A  82
 SO4  A   1 ( 4.4A)
None
None
None
 0.80A 3ua5A-1otgA:
undetectable		 3ua5A-1otgA:
16.28