SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1otk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		4 / 8 ALA A  70
LEU A  54
LEU A  17
ALA A  50
 None
 0.76A 1e7cA-1otkA:
undetectable		 1e7cA-1otkA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		3 / 3 TRP A 196
VAL A 106
TRP A 104
 None
 1.49A 1gmkC-1otkA:
undetectable
1gmkD-1otkA:
undetectable		 1gmkC-1otkA:
6.67
1gmkD-1otkA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		3 / 3 THR A   6
LEU A  10
LEU A  17
 None
 0.51A 1mz9C-1otkA:
undetectable		 1mz9C-1otkA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		6 / 12 LEU A 142
LEU A 209
ASN A 147
ASN A 205
ALA A 202
ALA A 198
 None
 1.23A 2bm9C-1otkA:
undetectable		 2bm9C-1otkA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		4 / 5 ARG A 132
THR A 110
LEU A 108
ALA A 131
 None
 1.33A 2e1qD-1otkA:
0.0		 2e1qD-1otkA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		4 / 7 GLY A  13
PHE A  53
PHE A 109
HIS A 105
 None
 0.71A 2y7wC-1otkA:
undetectable		 2y7wC-1otkA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		4 / 6 LEU A  39
GLY A  28
LEU A  23
SER A  20
 None
 0.97A 3aiaA-1otkA:
undetectable		 3aiaA-1otkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		5 / 12 LEU A   5
LEU A  12
GLY A 184
SER A 115
LEU A 112
 None
 0.97A 3nt1A-1otkA:
undetectable		 3nt1A-1otkA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		5 / 12 LEU A   5
LEU A  12
GLY A 184
SER A 115
LEU A 112
 None
 0.95A 3nt1B-1otkA:
undetectable		 3nt1B-1otkA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		5 / 12 LEU A   5
LEU A  12
GLY A 184
SER A 115
LEU A 112
 None
 1.08A 3pghD-1otkA:
undetectable		 3pghD-1otkA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		4 / 6 VAL A 106
VAL A 200
ILE A 101
ARG A 136
 None
 1.10A 3pyyA-1otkA:
undetectable		 3pyyA-1otkA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		4 / 5 LEU A  23
ALA A  38
THR A  94
PHE A 137
 None
 1.09A 3vasB-1otkA:
undetectable		 3vasB-1otkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		4 / 8 LEU A  69
GLU A  63
ALA A  57
LEU A  54
 None
 0.89A 4iizB-1otkA:
undetectable		 4iizB-1otkA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		5 / 12 TYR A  99
VAL A 200
SER A 138
LEU A 170
LEU A  83
 None
 1.36A 4qztA-1otkA:
undetectable		 4qztA-1otkA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		4 / 7 VAL A  84
ILE A 101
LEU A 112
LEU A 108
 None
 0.99A 4xo7A-1otkA:
undetectable		 4xo7A-1otkA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		4 / 5 ALA A  96
ALA A 159
ILE A 160
LEU A 209
 None
 0.80A 5jncD-1otkA:
undetectable		 5jncD-1otkA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		5 / 12 LEU A   5
LEU A  12
GLY A 184
SER A 115
LEU A 112
 None
 1.04A 5jvzA-1otkA:
undetectable		 5jvzA-1otkA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		5 / 12 LEU A   5
LEU A  12
GLY A 184
SER A 115
LEU A 112
 None
 1.06A 5jvzB-1otkA:
undetectable		 5jvzB-1otkA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		3 / 3 LEU A  69
ALA A  70
LEU A  10
 None
 0.51A 5uunB-1otkA:
undetectable		 5uunB-1otkA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		5 / 12 ILE A 101
LEU A 170
HIS A 105
ALA A 107
LEU A 192
 None
 0.95A 5zwrA-1otkA:
undetectable		 5zwrA-1otkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC
(Escherichia
coli) 		5 / 12 ILE A 101
LEU A 170
HIS A 105
ALA A 107
LEU A 192
 None
 0.99A 5zwrB-1otkA:
undetectable		 5zwrB-1otkA:
20.05