SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1otw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		5 / 12 THR A 146
ALA A 150
ILE A  43
PHE A 149
LEU A 218
 PQQ  A 500 (-3.7A)
PEO  A 600 (-3.1A)
None
None
None
 1.23A 1eiiA-1otwA:
undetectable		 1eiiA-1otwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		4 / 7 MET A 225
PHE A 176
MET A  33
ALA A  32
 None
 1.23A 1linA-1otwA:
0.0		 1linA-1otwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		4 / 6 LEU A 215
GLY A  20
ILE A  25
HIS A  26
 None
 0.83A 1yajF-1otwA:
undetectable		 1yajF-1otwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		4 / 8 TYR A 175
HIS A 154
LEU A 218
MET A 221
 PQQ  A 500 (-4.3A)
PQQ  A 500 ( 4.2A)
None
None
 1.36A 3uzzB-1otwA:
undetectable		 3uzzB-1otwA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		4 / 6 ASP A  83
ASP A  61
ARG A  80
GLU A 147
 None
PQQ  A 500 ( 4.5A)
PQQ  A 500 ( 4.9A)
PQQ  A 500 ( 4.1A)
 1.09A 4eysA-1otwA:
undetectable		 4eysA-1otwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		3 / 3 HIS A  30
TRP A 219
SER A 156
 None
 1.18A 4lrhD-1otwA:
undetectable		 4lrhD-1otwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		3 / 3 ALA A 228
GLN A  44
GLY A 105
 None
 0.60A 4odoC-1otwA:
undetectable		 4odoC-1otwA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		5 / 11 LEU A 148
LEU A 211
LEU A 215
TYR A 128
ILE A  57
 None
None
None
PQQ  A 500 (-4.6A)
PQQ  A 500 ( 4.1A)
 1.05A 4odrA-1otwA:
undetectable
4odrB-1otwA:
undetectable		 4odrA-1otwA:
16.14
4odrB-1otwA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		3 / 3 ILE A  57
ASP A 186
ARG A  50
 PQQ  A 500 ( 4.1A)
None
PQQ  A 500 (-2.5A)
 0.79A 4pstA-1otwA:
undetectable		 4pstA-1otwA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		3 / 3 TRP A  46
ILE A 153
SER A 156
 None
PQQ  A 500 (-3.6A)
None
 0.87A 5gqbA-1otwA:
undetectable		 5gqbA-1otwA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		4 / 6 TYR A 128
ASP A 186
ILE A  81
TYR A 175
 PQQ  A 500 (-4.6A)
None
None
PQQ  A 500 (-4.3A)
 1.20A 5igyA-1otwA:
undetectable		 5igyA-1otwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		4 / 6 TYR A 128
ASP A 186
ILE A  81
TYR A 175
 PQQ  A 500 (-4.6A)
None
None
PQQ  A 500 (-4.3A)
 1.30A 5ih0A-1otwA:
undetectable		 5ih0A-1otwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1otw COENZYME PQQ
SYNTHESIS PROTEIN C
(Klebsiella
pneumoniae) 		3 / 3 HIS A  30
HIS A  24
ARG A  50
 None
PQQ  A 500 (-3.7A)
PQQ  A 500 (-2.5A)
 1.13A 6b58A-1otwA:
undetectable		 6b58A-1otwA:
18.79