SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ouo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 1ouo NUCLEASE
(Vibrio
vulnificus) 		5 / 12 LEU A 119
ASN A 118
LEU A 116
GLN A 217
MET A 177
 None
 1.33A 1a28B-1ouoA:
undetectable		 1a28B-1ouoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 1ouo NUCLEASE
(Vibrio
vulnificus) 		5 / 12 LEU A 119
ASN A 118
LEU A 116
GLN A 217
MET A 177
 None
 1.39A 1sqnA-1ouoA:
undetectable		 1sqnA-1ouoA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1ouo NUCLEASE
(Vibrio
vulnificus) 		5 / 10 TYR A  43
ARG A 130
THR A 173
GLY A 168
ALA A 166
 None
 1.50A 2coiA-1ouoA:
undetectable
2coiB-1ouoA:
undetectable		 2coiA-1ouoA:
16.76
2coiB-1ouoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1ouo NUCLEASE
(Vibrio
vulnificus) 		5 / 10 TYR A  43
ARG A 130
THR A 173
GLY A 168
ALA A 166
 None
 1.49A 2coiA-1ouoA:
undetectable
2coiB-1ouoA:
undetectable		 2coiA-1ouoA:
16.76
2coiB-1ouoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1ouo NUCLEASE
(Vibrio
vulnificus) 		5 / 11 TYR A  43
ARG A 130
THR A 173
GLY A 168
ALA A 166
 None
 1.49A 2cojA-1ouoA:
undetectable
2cojB-1ouoA:
undetectable		 2cojA-1ouoA:
16.76
2cojB-1ouoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1ouo NUCLEASE
(Vibrio
vulnificus) 		5 / 9 TYR A  43
ARG A 130
THR A 173
GLY A 168
ALA A 166
 None
 1.39A 2cojA-1ouoA:
undetectable
2cojB-1ouoA:
undetectable		 2cojA-1ouoA:
16.76
2cojB-1ouoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 1ouo NUCLEASE
(Vibrio
vulnificus) 		3 / 3 ARG A 209
SER A 169
TYR A  35
 None
 1.05A 2q2hA-1ouoA:
undetectable
2q2hB-1ouoA:
undetectable		 2q2hA-1ouoA:
20.93
2q2hB-1ouoA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 1ouo NUCLEASE
(Vibrio
vulnificus) 		3 / 3 GLN A 217
ASP A 210
GLN A 225
 None
 0.84A 4aztA-1ouoA:
undetectable		 4aztA-1ouoA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1ouo NUCLEASE
(Vibrio
vulnificus) 		3 / 3 TYR A  35
SER A  41
TRP A  78
 None
 0.76A 5n8jB-1ouoA:
undetectable		 5n8jB-1ouoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1ouo NUCLEASE
(Vibrio
vulnificus) 		3 / 3 TYR A  35
SER A  41
TRP A  78
 None
 0.72A 5n8jA-1ouoA:
undetectable		 5n8jA-1ouoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1ouo NUCLEASE
(Vibrio
vulnificus) 		3 / 3 TYR A  35
SER A  41
TRP A  78
 None
 0.71A 5n8jD-1ouoA:
undetectable		 5n8jD-1ouoA:
20.45