SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ouu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		5 / 12 ILE B  11
ALA B  13
PHE B 118
ILE B  23
LEU B 110
 None
 1.09A 1dhfB-1ouuB:
undetectable		 1dhfB-1ouuB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		5 / 12 ILE B  11
ALA B  13
PHE B 118
ILE B  23
LEU B 110
 None
 1.08A 1drfA-1ouuB:
undetectable		 1drfA-1ouuB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		4 / 8 LEU B  71
THR B  84
LEU B  88
ALA B 140
 None
None
HEM  B 148 (-4.6A)
None
 0.85A 1fiqC-1ouuB:
undetectable		 1fiqC-1ouuB:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 148 (-4.1A)
None
HEM  B 148 (-4.2A)
HEM  B 148 (-3.3A)
 0.84A 1lh6A-1ouuB:
13.8		 1lh6A-1ouuB:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 CMO  A 144 (-4.7A)
None
None
CMO  A 144 ( 3.5A)
 1.00A 1wmqB-1ouuA:
1.1		 1wmqB-1ouuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 CMO  A 144 (-4.7A)
None
None
CMO  A 144 ( 3.5A)
 0.97A 1wrqA-1ouuA:
1.1		 1wrqA-1ouuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 CMO  A 144 (-4.7A)
None
None
CMO  A 144 ( 3.5A)
 0.97A 1wrqB-1ouuA:
1.1		 1wrqB-1ouuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		5 / 12 SER A 103
ILE A 106
PHE A 129
ALA A 131
ALA A 138
 None
 1.08A 2j0dA-1ouuA:
undetectable		 2j0dA-1ouuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		5 / 11 LEU A  77
ALA A 136
LEU A 137
ALA A  66
LYS A  69
 None
None
HEM  A 143 (-4.7A)
HEM  A 143 ( 3.9A)
None
 1.31A 3e22B-1ouuA:
undetectable		 3e22B-1ouuA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		5 / 12 GLU B   7
ILE B  11
PHE B 133
ALA B   6
THR B  10
 None
 1.22A 3ndiA-1ouuB:
undetectable		 3ndiA-1ouuB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		5 / 11 VAL A 133
LEU A  77
LEU A 137
GLY A  68
ALA A  66
 None
None
HEM  A 143 (-4.7A)
None
HEM  A 143 ( 3.9A)
 1.24A 3pghB-1ouuA:
undetectable		 3pghB-1ouuA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		4 / 8 VAL A 126
LEU A 107
LEU A 110
ILE A  67
 None
 0.91A 4lzrA-1ouuA:
undetectable		 4lzrA-1ouuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		4 / 8 PHE B  42
SER B  44
ALA B  62
PHE B 133
 HEM  B 148 (-4.1A)
HEM  B 148 ( 4.6A)
None
None
 0.83A 4rkuA-1ouuB:
undetectable
4rkuJ-1ouuB:
0.0		 4rkuA-1ouuB:
11.37
4rkuJ-1ouuB:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		3 / 3 THR B   4
ASP B   5
ALA B   6
 None
 0.05A 5g5gB-1ouuB:
undetectable		 5g5gB-1ouuB:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1ouu HEMOGLOBIN I
HEMOGLOBIN I
(Oncorhynchus
mykiss;
Oncorhynchus
mykiss) 		3 / 3 ASP B 108
ASN A 105
PHE B 133
 None
 0.90A 5jglB-1ouuB:
undetectable		 5jglB-1ouuB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		5 / 10 TRP B  15
ALA B  74
THR B  10
PHE B 133
VAL B 137
 None
 1.38A 6hu9C-1ouuB:
undetectable		 6hu9C-1ouuB:
16.62