SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ovw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 6 GLY A  36
TYR A 167
ALA A  33
GLU A   8
 None
 1.01A 1dmaB-1ovwA:
undetectable		 1dmaB-1ovwA:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		8 / 12 ALA A 143
TYR A 145
TYR A 171
ASP A 173
GLN A 175
GLU A 197
ASP A 199
GLU A 202
 DP5  A 401 (-3.6A)
DP5  A 401 (-3.5A)
None
DP5  A 401 (-3.4A)
DP5  A 401 (-4.2A)
DP5  A 401 ( 2.5A)
DP5  A 401 (-3.0A)
DP5  A 401 ( 2.9A)
 0.35A 1dy4A-1ovwA:
51.3		 1dy4A-1ovwA:
39.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		5 / 12 LEU A 110
TYR A 117
GLY A 153
TYR A 108
GLY A 170
 None
 1.17A 1httB-1ovwA:
undetectable		 1httB-1ovwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		5 / 12 LEU A 110
TYR A 117
GLY A 153
GLY A 170
ALA A 163
 None
None
None
None
PCA  A   1 ( 4.3A)
 1.18A 1httD-1ovwA:
undetectable		 1httD-1ovwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 6 PHE A 386
VAL A 384
LEU A 136
PHE A 129
 None
 1.00A 1wrlB-1ovwA:
undetectable		 1wrlB-1ovwA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		3 / 3 ASN A 242
ARG A 245
ASP A 352
 None
 0.78A 2qe6A-1ovwA:
undetectable		 2qe6A-1ovwA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		3 / 3 ASN A 242
ARG A 245
ASP A 352
 None
 0.81A 2qe6B-1ovwA:
undetectable		 2qe6B-1ovwA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		5 / 12 ASN A 183
ILE A  31
ILE A  85
ALA A 163
HIS A  38
 None
None
None
PCA  A   1 ( 4.3A)
None
 1.47A 2qmjA-1ovwA:
undetectable		 2qmjA-1ovwA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		5 / 12 GLY A 328
GLY A 240
GLY A 238
THR A 208
ILE A 210
 None
 1.17A 2wa2A-1ovwA:
undetectable		 2wa2A-1ovwA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		3 / 3 LEU A 110
TYR A 117
GLN A 151
 None
 0.70A 2wekA-1ovwA:
undetectable		 2wekA-1ovwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 5 SER A 296
TYR A 287
PHE A 251
VAL A 248
 None
 1.30A 2x7hA-1ovwA:
undetectable		 2x7hA-1ovwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 5 SER A 296
TYR A 287
PHE A 251
VAL A 248
 None
 1.31A 2x7hB-1ovwA:
undetectable		 2x7hB-1ovwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_2
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 4 VAL A 260
ARG A 285
HIS A 286
PHE A 266
 None
 1.17A 3apwA-1ovwA:
0.1		 3apwA-1ovwA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 7 HIS A 243
GLN A 289
PHE A 266
VAL A 131
 None
 1.02A 3jwqC-1ovwA:
undetectable		 3jwqC-1ovwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 8 GLY A 222
GLN A 191
GLU A 227
THR A 224
 None
 0.91A 3rglA-1ovwA:
undetectable		 3rglA-1ovwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 8 GLY A  36
TYR A 167
ALA A  33
GLU A   8
 None
 0.92A 4hyfB-1ovwA:
undetectable		 4hyfB-1ovwA:
19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		9 / 9 ASN A 141
ALA A 143
TYR A 145
TYR A 171
ASP A 173
GLU A 197
ASP A 199
GLU A 202
TRP A 347
 DP5  A 401 ( 4.2A)
DP5  A 401 (-3.6A)
DP5  A 401 (-3.5A)
None
DP5  A 401 (-3.4A)
DP5  A 401 ( 2.5A)
DP5  A 401 (-3.0A)
DP5  A 401 ( 2.9A)
DP5  A 401 (-3.7A)
 0.49A 4ipmA-1ovwA:
52.1		 4ipmA-1ovwA:
36.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		3 / 3 GLU A  14
LYS A  12
ASN A  90
 None
 0.86A 4y1dA-1ovwA:
0.0
4y1dD-1ovwA:
undetectable		 4y1dA-1ovwA:
16.17
4y1dD-1ovwA:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		5 / 12 LEU A 110
TYR A 117
GLY A 153
TYR A 108
GLY A 170
 None
 1.25A 5e3iA-1ovwA:
undetectable		 5e3iA-1ovwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		5 / 12 TYR A 117
GLY A 153
TYR A 108
GLY A 170
ALA A 163
 None
None
None
None
PCA  A   1 ( 4.3A)
 1.19A 5e3iA-1ovwA:
undetectable		 5e3iA-1ovwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		5 / 11 TYR A 117
GLY A 153
TYR A 108
GLY A 170
ALA A 163
 None
None
None
None
PCA  A   1 ( 4.3A)
 1.20A 5e3iB-1ovwA:
undetectable		 5e3iB-1ovwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 5 GLY A 392
THR A 397
GLN A 271
THR A 125
 None
 0.87A 5h5fA-1ovwA:
undetectable		 5h5fA-1ovwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 4 LEU A 122
MET A 332
ILE A 394
LEU A 283
 None
 1.15A 5nfpA-1ovwA:
0.0		 5nfpA-1ovwA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 4 GLU A 227
THR A 224
THR A 179
LEU A 220
 None
 1.42A 5v96A-1ovwA:
undetectable		 5v96A-1ovwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 6 ILE A 200
LEU A 122
HIS A 121
PHE A 386
 None
 1.02A 5vkqC-1ovwA:
undetectable
5vkqD-1ovwA:
undetectable		 5vkqC-1ovwA:
13.38
5vkqD-1ovwA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 5 GLN A 379
VAL A 378
PRO A 382
THR A 368
 None
 1.50A 6cduI-1ovwA:
undetectable
6cduJ-1ovwA:
0.0		 6cduI-1ovwA:
23.36
6cduJ-1ovwA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ovw ENDOGLUCANASE I
(Fusarium
oxysporum) 		4 / 6 LYS A 330
GLN A 331
LEU A 283
PHE A 272
 None
 1.15A 6nmpC-1ovwA:
undetectable
6nmpJ-1ovwA:
undetectable		 6nmpC-1ovwA:
19.35
6nmpJ-1ovwA:
10.34