SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ow0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens) 		4 / 7 LEU C 123
SER C 122
ASP C 110
PHE C 106
 None
NAG  C 740 (-3.4A)
NAG  C 740 (-4.6A)
None
 1.25A 1ismB-1ow0C:
undetectable		 1ismB-1ow0C:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens) 		4 / 5 PRO C 180
ILE C  42
GLY C  75
TYR C 181
 None
 1.08A 2jkjD-1ow0C:
0.0		 2jkjD-1ow0C:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens) 		4 / 5 PRO C 180
ILE C  42
GLY C  75
TYR C 181
 None
 1.08A 2jkjF-1ow0C:
0.0		 2jkjF-1ow0C:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1ow0 IG ALPHA-1 CHAIN C
REGION
(Homo
sapiens) 		3 / 3 ARG A 401
VAL A 381
THR A 397
 None
 0.80A 2nnkA-1ow0A:
undetectable		 2nnkA-1ow0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1ow0 IG ALPHA-1 CHAIN C
REGION
IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens;
Homo
sapiens) 		4 / 8 MET A 433
LEU A 384
ARG C  52
SER A 415
 None
 1.19A 2qd2A-1ow0A:
undetectable		 2qd2A-1ow0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1ow0 IG ALPHA-1 CHAIN C
REGION
(Homo
sapiens) 		4 / 5 ASN A 316
ARG A 250
HIS A 436
ALA A 438
 None
 1.43A 3frqA-1ow0A:
undetectable		 3frqA-1ow0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1ow0 IG ALPHA-1 CHAIN C
REGION
(Homo
sapiens) 		4 / 7 ASN A 316
ARG A 250
HIS A 436
ALA A 438
 None
 1.45A 3frqB-1ow0A:
undetectable		 3frqB-1ow0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1ow0 IG ALPHA-1 CHAIN C
REGION
(Homo
sapiens) 		3 / 3 ARG A 401
VAL A 381
THR A 397
 None
 0.87A 3k4vA-1ow0A:
undetectable		 3k4vA-1ow0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1ow0 IG ALPHA-1 CHAIN C
REGION
(Homo
sapiens) 		3 / 3 ARG A 401
VAL A 381
THR A 397
 None
 0.79A 3nduD-1ow0A:
undetectable		 3nduD-1ow0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1ow0 IG ALPHA-1 CHAIN C
REGION
(Homo
sapiens) 		3 / 3 ARG A 401
VAL A 381
THR A 397
 None
 0.79A 3pwrA-1ow0A:
undetectable		 3pwrA-1ow0A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1ow0 IG ALPHA-1 CHAIN C
REGION
(Homo
sapiens) 		3 / 3 ARG A 401
VAL A 381
THR A 397
 None
 0.80A 3tl9A-1ow0A:
undetectable		 3tl9A-1ow0A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens) 		3 / 3 TYR C 173
ARG C 171
SER C 187
 None
 1.09A 4dr2I-1ow0C:
undetectable
4dr2J-1ow0C:
undetectable		 4dr2I-1ow0C:
18.98
4dr2J-1ow0C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ow0 IG ALPHA-1 CHAIN C
REGION
IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens;
Homo
sapiens) 		4 / 5 MET A 433
LEU A 384
ARG C  52
SER A 415
 None
 1.17A 4kmmB-1ow0A:
undetectable		 4kmmB-1ow0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens) 		3 / 3 TYR C 173
ARG C 171
SER C 187
 None
 1.11A 4lf7I-1ow0C:
undetectable
4lf7J-1ow0C:
undetectable		 4lf7I-1ow0C:
18.98
4lf7J-1ow0C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens) 		3 / 3 TYR C 173
ARG C 171
SER C 187
 None
 1.11A 4lf8I-1ow0C:
undetectable
4lf8J-1ow0C:
undetectable		 4lf8I-1ow0C:
18.98
4lf8J-1ow0C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1ow0 IG ALPHA-1 CHAIN C
REGION
IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER C  91
GLU C  49
GLU A 389
 None
None
GAL  A 506 (-4.1A)
 0.85A 4ymgB-1ow0C:
undetectable		 4ymgB-1ow0C:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens) 		4 / 5 LEU C  96
TYR C 181
LEU C  94
TYR C  77
 None
 1.35A 5ki6A-1ow0C:
undetectable		 5ki6A-1ow0C:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens) 		4 / 6 LYS C  13
GLN C  27
PHE C  64
LEU C  96
 None
 1.31A 6nmpC-1ow0C:
undetectable
6nmpJ-1ow0C:
undetectable		 6nmpC-1ow0C:
21.58
6nmpJ-1ow0C:
14.01